Accidents in engineered systems are usually generated by complex socio-technical factors.It is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system safety.Ba...Accidents in engineered systems are usually generated by complex socio-technical factors.It is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system safety.Based on system and control theories,System-Theoretic Accident Model and Processes(STAMP)is a widely recognized approach for accident analysis.In this paper,we propose a STAMP-Game model to analyze accidents in oil and gas storage and transportation systems.Stakeholders in accident analysis by STAMP can be regarded as players of a game.Game theory can,thus,be adopted in accident analysis to depict the competition and cooperation between stakeholders.Subsequently,we established a game model to study the strategies of both supervisory and supervised entities.The obtained results demonstrate that the proposed game model allows for identifying the effectiveness deficiency of the supervisory entity,and the safety and protection altitudes of the supervised entity.The STAMP-Game model can generate quantitative parameters for supporting the behavior and strategy selections of the supervisory and supervised entities.The quantitative data obtained can be used to guide the safety improvement,to reduce the costs of safety regulation violation and accident risk.展开更多
Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress ...Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to cirrhosis.Patients with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver cirrhosis.Sarcopenic obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for chronicliver disease in patients with obesity and a prognostic negative marker for the evolution of liver cirrhosis and the results of liver transplantation.Cirrhotic patients with obesity are at high risk for depletion of various fat-soluble,water-soluble vitamins and trace elements and should be supplemented appropriately.Diet,physical activity and protein intake should be carefully monitored in these fragile patients according to recent recommendations.Bariatric surgery is sporadically used in patients with morbid obesity and cirrhosis also in the setting of liver transplantation.The risk of sarcopenia,micronutrient status,and the recommended supplementation in patients with obesity and cirrhosis are discussed in this review.Furthermore,the indications and contraindications of bariatric surgery-induced weight loss in the cirrhotic patient with obesity are discussed.展开更多
The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers ...The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.展开更多
Edible insects are advocated as sustainable and healthy food and feed.However,commercially produced insects are often low in n‐3 fatty acids and have suboptimal n‐6/n‐3 ratios.A certain amount and proportion of the...Edible insects are advocated as sustainable and healthy food and feed.However,commercially produced insects are often low in n‐3 fatty acids and have suboptimal n‐6/n‐3 ratios.A certain amount and proportion of these FAs is required to optimize human health.Flaxseed oil consists primarily(57%)out of alpha‐linolenic acid.An experiment was conducted to quantify the effect of flaxseed oil provision on fatty acid composition and to determine the quantity needed to attain a beneficial n‐6/n‐3 ratio.Three species were used in the experiment:house crickets(Acheta domesticus[L.]),lesser mealworms(Alphitobius diaperinus[Pfanzer])and black soldier flies(Hermetia illucens[L.]).These were provided with either a control diet or a diet enriched with 1%,2%,or 4%flaxseed oil during their larval/nymphal stage.Fatty acid profiles of diets and insects were determined via GC‐MS.The three species had distinct fatty acid profiles on all four diets,but responded similarly to flaxseed oil addition.For each percent added to the diet,the alpha‐linolenic acid content of the insects increased by 2.3%–2.7%.Four percent addition increased the n‐3 fatty acid content 10–20 fold in the three species and thereby strongly decreased n‐6/n‐3 ratios from 18–36 to 0.8–2.4.A ratio below 5 is considered optimal for human health and was achieved by 2%flaxseed oil inclusion for house crickets and lesser mealworms,and at 1%inclusion for black soldier flies.Adding a source of n‐3 fatty acids to insect diets can thus improve the nutritional quality of insects.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52004030)the R&D Program of Beijing Municipal Education Commission(Grant No.KM202310016003)the Exchange Program of High-end Foreign Experts of Ministry of Science and Technology,China(Grant No.G2022178013L)。
文摘Accidents in engineered systems are usually generated by complex socio-technical factors.It is beneficial to investigate the increasing complexity and coupling of these factors from the perspective of system safety.Based on system and control theories,System-Theoretic Accident Model and Processes(STAMP)is a widely recognized approach for accident analysis.In this paper,we propose a STAMP-Game model to analyze accidents in oil and gas storage and transportation systems.Stakeholders in accident analysis by STAMP can be regarded as players of a game.Game theory can,thus,be adopted in accident analysis to depict the competition and cooperation between stakeholders.Subsequently,we established a game model to study the strategies of both supervisory and supervised entities.The obtained results demonstrate that the proposed game model allows for identifying the effectiveness deficiency of the supervisory entity,and the safety and protection altitudes of the supervised entity.The STAMP-Game model can generate quantitative parameters for supporting the behavior and strategy selections of the supervisory and supervised entities.The quantitative data obtained can be used to guide the safety improvement,to reduce the costs of safety regulation violation and accident risk.
文摘Obesity and metabolic syndrome are considered as responsible for a condition known as the non-alcoholic fatty liver disease that goes from simple accumulation of triglycerides to hepatic inflammation and may progress to cirrhosis.Patients with obesity also have an increased risk of primary liver malignancies and increased body mass index is a predictor of decompensation of liver cirrhosis.Sarcopenic obesity confers a risk of physical impairment and disability that is significantly higher than the risk induced by each of the two conditions alone as it has been shown to be an independent risk factor for chronicliver disease in patients with obesity and a prognostic negative marker for the evolution of liver cirrhosis and the results of liver transplantation.Cirrhotic patients with obesity are at high risk for depletion of various fat-soluble,water-soluble vitamins and trace elements and should be supplemented appropriately.Diet,physical activity and protein intake should be carefully monitored in these fragile patients according to recent recommendations.Bariatric surgery is sporadically used in patients with morbid obesity and cirrhosis also in the setting of liver transplantation.The risk of sarcopenia,micronutrient status,and the recommended supplementation in patients with obesity and cirrhosis are discussed in this review.Furthermore,the indications and contraindications of bariatric surgery-induced weight loss in the cirrhotic patient with obesity are discussed.
文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry.
文摘Edible insects are advocated as sustainable and healthy food and feed.However,commercially produced insects are often low in n‐3 fatty acids and have suboptimal n‐6/n‐3 ratios.A certain amount and proportion of these FAs is required to optimize human health.Flaxseed oil consists primarily(57%)out of alpha‐linolenic acid.An experiment was conducted to quantify the effect of flaxseed oil provision on fatty acid composition and to determine the quantity needed to attain a beneficial n‐6/n‐3 ratio.Three species were used in the experiment:house crickets(Acheta domesticus[L.]),lesser mealworms(Alphitobius diaperinus[Pfanzer])and black soldier flies(Hermetia illucens[L.]).These were provided with either a control diet or a diet enriched with 1%,2%,or 4%flaxseed oil during their larval/nymphal stage.Fatty acid profiles of diets and insects were determined via GC‐MS.The three species had distinct fatty acid profiles on all four diets,but responded similarly to flaxseed oil addition.For each percent added to the diet,the alpha‐linolenic acid content of the insects increased by 2.3%–2.7%.Four percent addition increased the n‐3 fatty acid content 10–20 fold in the three species and thereby strongly decreased n‐6/n‐3 ratios from 18–36 to 0.8–2.4.A ratio below 5 is considered optimal for human health and was achieved by 2%flaxseed oil inclusion for house crickets and lesser mealworms,and at 1%inclusion for black soldier flies.Adding a source of n‐3 fatty acids to insect diets can thus improve the nutritional quality of insects.