The hollow core photonic crystal waveguide biosensor is designed and described.The biosensor was tested in experiments for artificial sweetener identifcation in drinks.The photonic crystal waveguide biosensor has a hi...The hollow core photonic crystal waveguide biosensor is designed and described.The biosensor was tested in experiments for artificial sweetener identifcation in drinks.The photonic crystal waveguide biosensor has a high sensitivity to the optical properties of liquids flling up the hollow core.The compactness,good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promnising for v arious biomedical applicat ions.展开更多
The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance.This common strategy,however,disregards the promising possibility of sim...The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance.This common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain.Here,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells.IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral ranges.We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.展开更多
基金supported by Grant No.224014 PHOTONICS4LIFE of FP7-ICT-2007-2Project No.1.4.09+3 种基金RF Governmental contracts 11.519.11.2035,14.B37.21.0728 and 14.B37.21.0563FiDiPro,TEKES Program(40111/11),FinlandSCOPES EC,Uzb/Switz/RF,Swiss NSF,IZ74ZO 137423/1RF President's Grant 1177.2012.2"Scientific Schools".
文摘The hollow core photonic crystal waveguide biosensor is designed and described.The biosensor was tested in experiments for artificial sweetener identifcation in drinks.The photonic crystal waveguide biosensor has a high sensitivity to the optical properties of liquids flling up the hollow core.The compactness,good integration ability to different optical systems and compatibility for use in industrial settings make such biosensor very promnising for v arious biomedical applicat ions.
基金supported by the Russian Foundation for Basic Research(RFBR grant no.19-32-90249)supported by RFBR grant no.18-52-16025+1 种基金supported by RFBR grant no.18-29-08046supported in part by the Ministry of Science&Technology of Israel(grant no.79518).
文摘The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical resonance.This common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral domain.Here,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid cells.IMOS offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral ranges.We apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.
