Interaction of activity involvement and recreational location selection behavior in Lowland City:A case study of public parks in Saga City,Japan

Public parks provide many benefits to the community as the representatives of green area. The allocation of public places plays an extremely important role in the daily lives of inhabitants especially for recreational use that could enhance the quality of life of residents in the vicinity. To understand park users’ behavior is one of the most important prerequisites for as-sessing the participation in public service from the park users’ point of view. The pattern of park utilization on location and activity selection are important elements in behavioral study, while the public parks topograph may also influence the typical user’s be-havior. Questionnaire survey on park utilization was used to investigate the interaction between activity involvement and recrea-tional location with the use of linear discriminant analysis (LDA) model. The study found that public park users’ behavior is influenced not only by social characteristics but also by the recreational activities and their specific location characteristics. We found that about 45 percent of park visitors are local residents living within a radius of 3 km preferred travel to parks near their residential area. This implies that location selection behavior is correlated with travel distance, travel time and travel cost. Visit frequencies and on site expenditures reflect the recreation behavior for different type of activities. The overall information can be usefully applied by decision makers to launch appropriate public policy in consistence with the useful results of this study.

Relationship between nutritional therapy and beneficial bacteria ratio in severe disease

Objective:To evaluate relationship between changes in the beneficial bacteria in intensive care unit(ICU)patients and nutritional therapy type.Methods:Ten patients aged≥18 years admitted to the ICU between January and December 2020,were included.Good enteral nutrition was defined as early achievement of target calorie intake through enteral feeding.The ratio of beneficial bacteria at the first and second bowel movements after each patient’s admission was calculated and the patients were classified into the increase or decrease group.Among all patients,five each were in the increase and decrease groups.We investigated patient background,changes in sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)Ⅱscores,nutritional doses or methods,and clinical outcomes.Results:No relationship was found between changes in the ratio of beneficial bacteria and changes in SOFA/APACHEⅡscores at the time of admission.The rate of good enteral nutrition was significantly higher in the increase group than in the decrease group(4/5 vs.0/5,P=0.01).Conclusions:An increase in beneficial bacteria may be significantly related to the early establishment of enteral nutrition.In the future,accumulating cases may make it possible to establish a new nutritional strategy for critically ill patients from an intestinal microbiota perspective.

Enhancing clinical proficiency through laparoscopic training using Japanese origami

Objective This study aimed to investigate the clinical efficacy of laparoscopic training using origami,a traditional Japanese papercraft,using laparoscopic forceps to create origami cranes.Methods In this retrospective study,4 surgeons were randomly divided into 2 groups:The training group,consisting of surgeons 1 and 2,and the non-training group,consisting of surgeons 3 and 4.Over the course of a one-year study period,the training group regularly underwent laparoscopic surgery training with a dry box,wherein they folded a total of 1000 origami cranes using laparoscopic instruments.The non-training group periodically underwent common laparoscopic surgery training of techniques such as suturing and ligation.Each surgeon regularly performed the transabdominal preperitoneal approach for inguinal hernias.Each training was conducted concurrently with the surgeries.The procedure time(peritoneum detachment,mesh placement,and closure of the peritoneum),total operation time(time from peritoneum detachment to closure of the peritoneum),and surgical outcomes were examined.Results The training group showed greater improvement in the total operation time and more stable performance than the non-training group.Additionally,the time taken for peritoneum detachment was significantly shorter in the training group.Conclusion Laparoscopic training using origami has the potential to enhance laparoscopic surgical skills and improve surgical outcomes.

Improving Prediction Efficiency of Machine Learning Models for Cardiovascular Disease in IoST-Based Systems through Hyperparameter Optimization

This study explores the impact of hyperparameter optimization on machine learning models for predicting cardiovascular disease using data from an IoST(Internet of Sensing Things)device.Ten distinct machine learning approaches were implemented and systematically evaluated before and after hyperparameter tuning.Significant improvements were observed across various models,with SVM and Neural Networks consistently showing enhanced performance metrics such as F1-Score,recall,and precision.The study underscores the critical role of tailored hyperparameter tuning in optimizing these models,revealing diverse outcomes among algorithms.Decision Trees and Random Forests exhibited stable performance throughout the evaluation.While enhancing accuracy,hyperparameter optimization also led to increased execution time.Visual representations and comprehensive results support the findings,confirming the hypothesis that optimizing parameters can effectively enhance predictive capabilities in cardiovascular disease.This research contributes to advancing the understanding and application of machine learning in healthcare,particularly in improving predictive accuracy for cardiovascular disease management and intervention strategies.

Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet

Trimethylamine N-oxide(TMAO)is a risk factor of various chronic diseases,which was produced by metabolism from precursors to trimethylamine(TMA)in gut and the oxidation from TMA in liver.The TMA generation was influenced by diet,mainly due to the rich TMAO precursors in diet.However,it was still unclear that the effects of different proportion and source of macronutrients in different dietary pattern on the production process of TMAO.Here,the generation of TMA from precursors and TMAO from TMA was determined after single oral choline chloride and intraperitoneal injection TMA,respectively,in mice fed with carbohydrates,proteins and fats in different proportion and sources.The results suggested that the generation of TMAO was increased by low non-meat protein and high fat via enhancing the production of TMAO from TMA,and decreased by plant protein and refined sugar via reducing TMA production from precursors in gut and TMAO transformation from TMA in liver.The high fat and high sugar diets accelerating the development of atherosclerosis did not increase the production of TMAO,the risk factor for atherosclerosis,which indicated that the dietary compositions rather than the elevated TMAO level might be a more key risk factor for atherosclerosis.

Understanding of Five Grains for YANG:a way to straighten Asians’dietary structure

According to the general opinion,grains should occupy the largest amount of human food each day,but this grain-based eating habit does not allow human life to be extended.Grains are high in carbohydrates and five commonly recognized plant hormones,namely auxin,gibberellin,cytokinin,abscisic acid,and ethylene.Through in-depth analysis of ancient books,it was found that five grains for support:support is a restriction,and it means the essence,which means that grains should be eaten less,and it is the essence of the least daily intake.To correctly understand the Chinese dietary concept of"five grains for support"is the basis for improving Asian dietary health and promoting Asian human health.

Influence of Heavy Fuel Oil on the Thermo-Physical and Erodibility Properties of Earthen Materials

This study focuses on the use of heavy fuel oil in construction material in Burkina Faso. Its mixture with silty or clayey soil is used as a coating to reinforce the walls of raw earth constructions which are very sensitive to water. The interest of this study is to determine erodibility, water content, while highlighting the influence of the porosity accessible by water on thermal diffusion in construction material containing heavy fuel oil. The heavy fuel oil was mixed with a silty-clayey soil, in different proportions, and water to make bricks samples on which tests were carried out. At the end of the experimental tests, it appears that the water content increases gradually, but not significantly with the addition of heavy fuel oil, which causes a slight increase in the speed of heat propagation through the material with reduced porosity, particularly those containing higher quantities of heavy fuel oil. Conversely, we note a good performance of heavy fuel oil in terms of water resistance properties such as porosity accessible by water and erodibility. This allows us to conclude that the mixture of heavy fuel oil and silty-clayey soil used as a coating material could greatly reduce water infiltration into the walls of housing constructions with raw earthen materials.

菠萝叶片绿色组织与贮水组织中代谢物水平的昼夜变化(英文)

研究了景天酸代谢 (CAM)植物菠萝叶片绿色组织与贮水组织 (WSP)的苹果酸、柠檬酸、异柠檬酸、淀粉、果糖、葡萄糖、蔗糖、葡糖 1 磷酸 (G 1 P)、葡糖 6 磷酸 (G 6 P)、果糖 6 磷酸 (F 6 P)、草酰乙酸(OAA)及磷酸烯醇式丙酮酸 (PEP)水平的昼夜变化。夜间苹果酸的积累仅发生在绿色组织中 ,表明只有绿色组织才能进行CAM。可溶性已糖 (葡萄糖和果糖 )是绿色组织中夜间苹果酸累积的主要碳源。绿色组织G 1 P、G 6 P和F 6 P水平在夜间的初期上升 ,后期下降 ,昼间的头 3h仍下降 ,3h后变化不明显。绿色组织中OAA和PEP水平也发生昼夜变化。在贮水组织中没有测到淀粉、蔗糖、OAA和PEP。除葡萄糖和果糖外 ,WSP中其它代谢物的含量都远低于绿色组织 ,而且WSP中所有代谢物都无明显的昼夜变化。

菠萝叶片绿色组织与贮水组织的腺苷酸及焦磷酸水平的昼夜变化(英文)

研究了景天酸代谢 (CAM )植物菠萝(Ananascomosus)叶片绿色组织与贮水组织的苹果酸、腺苷酸及焦磷酸含量的昼夜变化。夜间苹果酸的积累仅发生在绿色组织中 ,而且 ,其含量也远高于贮水组织。绿色组织中能荷和无机磷含量夜间增高 ,白天下降。绿色组织中焦磷酸含量夜间增加 ,在白天的头几个小时迅速下降到低的水平 ,然后保持稳定。与绿色组织相比 ,贮水组织中ATP、ADP、无机磷和焦磷酸的含量低得多 ,且不表现昼夜变化 ,在贮水组织中没有测到AMP。

菠萝叶片绿色组织与贮水组织液泡膜ATPase和焦磷酸酶特性(英文)

研究了景天酸代谢 (CAM)植物菠萝叶片绿色组织与贮水组织液泡膜ATPase和焦磷酸酶 (PPase)特性。绿色组织有较高的ATPase和PPase活力。贮水组织 (绿色组织 )ATPase和PPase活力的最佳温度分别为 43和 49℃ (3 7和 46℃ )。当温度小于最佳温度时 ,ATPase和PPase活力随着温度的上升而上升 ;而当温度大于最佳温度时 ,ATPase和PPase活力随着温度的上升而下降。在 (1 0～ 46℃ ) 1 0～3 7℃的温度范围 ,绿色组织 (PPase)ATPase活力随着温度的上升而上升的速度大于贮水组织中(PPase)ATPase活力上升的速度 ,绿色组织有 (相对 )较高的ATPase和PPase活力 ;但在 (49～ 6 1℃ )43～ 5 5℃的温度范围 ,贮水组织中 (PPase)ATPase活力随着温度的上升而下降的速度小于绿色组织中(PPase)ATPase活力下降的速度 ,贮水组织有相对较高的ATPase和PPase活力。此外 ,贮水组织中这两种酶活力的热稳定性强于绿色组织中这两种酶活力的热稳定性。对这两种酶活力的最佳

1,3-交替香豆素-硫杂杯[4]荧光探针对Fe^3＋和牛血红蛋白的光谱识别

以1,3-交替二乙酯硫杂杯[4]芳烃和7-羟基香豆素为原料,分步取代杯芳烃下沿,合成得到1,3-交替香豆素-硫杂杯[4]芳烃荧光探针1。在DMSO/H2O(φ,3/7,pH 7)溶液中,探针1发射的强荧光被Fe3+选择性猝灭;Fe3+使探针1的紫外吸收显著增强。相同条件下其他常见金属离子的加入对探针1的荧光及吸收光谱无影响,探针在水溶液介质中仅对Fe3+高选择性识别,荧光和吸收光谱法的检测限均达10-8 mol·L-1。光谱滴定、等温滴定量热及质谱法均测出探针1与Fe3+形成1∶1配合物,作用常数达105 L·mol-1。从摩尔结合自由能和结合熵分别表明配合作用为自发过程。同时,在DMSO/H2O(φ,1/9,Tris-HCl,pH7,0.1mol·L-1 NaCl)介质中,探针1能选择性猝灭识别牛血红蛋白(BHb),线性范围在0.2~3.0μg·mL-1,检测限达0.12μg·mL-1。为一种选择性识别Fe3+和BHb的杯芳烃荧光探针。

硫杂杯[4]荧光探针的离子识别及分子逻辑门研究

以硫杂杯[4]芳烃为母体,在其1,3-位连接羟乙基邻苯二甲酰亚胺,2,4-位以三氮唑为连接基,将苄基引入硫杂杯[4]芳烃的下沿,得到硫杂杯[4]-邻苯二甲酰亚胺衍生物荧光探针(s1)。探针s1发射强烈荧光,在CH_3CN介质中的相对荧光量子产率为0.43。在DMF/H_2O介质中,以310nm为激发波长,Fe^(3+)能选择性猝灭探针s1在390nm处的荧光;在CH_3CN介质中,以245nm为激发波长,I^-能选择性猝灭探针s1在310nm处的荧光,光谱滴定和等温滴定量热均测出探针s1与Fe^(3+)或与I^-形成1∶1配合物,结合常数均达105。结合自由能表明配合为自发过程。荧光猝灭检测Fe^(3+)和I^-的浓度线性范围分别为1.0×10^(-7)~1.6×10^(-4) mol·L^(-1)和1.0×10^(-7)~8.5×10^(-5) mol·L^(-1),检测限分别为2.30×10^(-8) mol·L^(-1)和1.17×10^(-8) mol·L^(-1)。同时,利用识别和竞争配合作用,控制Fe^(3+)和F^-的输入使探针s1发射荧光或荧光猝灭,构建了分子水平上的逻辑电路。红外光谱推测探针s1分子中三氮唑基的氮原子参与了识别Fe^(3+)的配位,而探针s1分子中三氮唑环上的芳氢与I^-形成氢键而实现识别。

Leaching of phosphorus from incinerated sewage sludge ash by means of acid extraction followed by adsorption on orange waste gel

Ashes from sewage sludge incineration have a high phosphorus content, approximately 8% （W/W）, which indicates a potential resource of the limiting nutrient. Incineration of sewage sludge with subsequent recovery of phosphorus is a relatively new sludge treatment technique. In this article, the leaching of phosphorus by using sulfuric acid as well as hydrochloric acid by means of several batch experiments was presented. At the same time a selective recovery of phosphorus by adsorption was also discussed. The effects of acid concentration, temperature and time on extraction were studied. The phosphorus leaching increased with the increase in acid concentration and temperature. Kinetic studies showed that the complete leaching of phosphorus took place in less than 4 h. Selective adsorption of phosphorus by using orange waste gel provided a hint for recovery of this natural resource, which eventually could meet the ever-increasing requirement for phosphorus. The overall results indicated that the incinerated sewage sludge ash can be treated with acid to efficiently recover phosphorus and thus can be considered a potentially renewable source of phosphorus.

Aberrant gene methylation in the peritoneal fluid is a risk factor predicting peritoneal recurrence in gastric cancer

AIM:To investigate whether gene methylation in the peritoneal fluid (PF) predicts peritoneal recurrence in gastric cancer patients.METHODS: The gene methylation of CHFR (checkpoint with forkhead and ring finger domains), p16, RUNX3 (runt-related transcription factor 3), E-cadherin, hMLH1 (mutL homolog 1), ABCG2 (ATP-binding cassette, sub-family G, member 2) and BNIP3 (BCL2/adenovirus E1B 19 kDa interacting protein 3) were analyzed in 80 specimens of PF by quantitative methylation-specific polymerase chain reaction (PCR). Eighty patients were divided into 3 groups; Group A (n=35):the depth of cancer invasion was less than the muscularis propria; Group B (n=31): the depth of cancer invasion was beyond the muscularis propria. Both group A and B were diagnosed as no cancer cells in peritoneal cytology and histology; Group C (n=14): disseminated nodule was histologically diagnosed or cancer cells were cytologically defi ned in the peritoneal cavity.RESULTS: The positive rates of methylation in CHFR, E-cadherin and BNIP3 were significantly different among the 3 groups and increased in order of group A, B and C (0%,0% and 21% in CHFR, P<0.05; 20%, 45% and 50% in E-cadherin, P<0.05;26%,35% and 71% in BNIP3, P<0.05). In addition, the multigene methylation rate among CHFR, E-cadherin and BNIP3 was correlated with group A, B and C (9%,19% and 57%, P<0.001). Moreover, the prognosis was analyzed in group B, excluding 3 patients who underwent a non-curative resection. Two of the 5 patients with multigene methylation showed peritoneal recurrence after surgery, while those without or with a single gene methylation did not experience recurrence (P<0.05).CONCLUSION: This study suggested that gene methylation in the PF could detect occult neoplastic cells in the peritoneum and might be a risk factor for peritoneal metastasis.

Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature

A depressed lesion was found at a gastric angle of 76-yearold Japanese woman by esophagogastroduodenoscopy. Four years prior, she was diagnosed with a Helicobacter pylori infection but no eradication was performed. The pathological diagnosis of biopsy specimens was signet-ring cell carcinoma. Endoscopic submucosal dissection(ESD) was performed. Histopathological examination of the ESD specimen revealed proliferation of well-differentiated tubular adenocarcinoma mimicking fundic gland cells at the deep layer of the lamina propria mucosae. These tumor cells expressed focally pepsinogen-Ⅰ, diffusely MUC6, and scattered H^+/K^+ ATPase according to immunohistochemistry. Therefore, we diagnosed this tumor as gastric adenocarcinoma of fundic gland type(GA-FG). Adjacent to the GA-FG, proliferation of signet-ring cell carcinoma which diffusely expressed MUC 2 and MUC 5AC was observed. Intestinal metaplasia was focally observed in the surrounding mucosa of the signet-ring cell carcinoma. To the best of our knowledge, this is the first case report of GA-FG with a signet-ring cell carcinoma component. The origin of signet-ring cell carcinoma, i.e., whether it accidentally arose from a non-neoplastic mucosa and coexisted with the GA-FG or dedifferentiated from the GA-FG is unclear at present. We expect the accumulation of similar cases and further analysis to clarify this issue.

腐殖酸与盐分浓度对石灰加固土有明黏土的影响以及微观结构研究

首先从力学性质方面考察了有机质之一的腐殖酸和盐分浓度对于石灰加固土的影响。分析的结果显示对于腐殖酸含量较高的黏土由于凝硬反应被阻碍使得加固土的强度与屈服应力较小,并且由于盐分浓度较高时腐殖酸活性降低,因此随着盐分浓度的增加腐殖酸对于石灰加固土的影响减小。然后通过分析加固土的微观结构,我们讨论了石灰加固土的力学性质与微观结构之间的关联性。

Gallbladder cancer: Clinical and pathological approach

Gallbladder cancer(GBC) shows a marked geographical variation in its incidence. Middle-aged and elderly women are more commonly affected. Risk factors for its development include the presence of gallstones, chronic infection and pancreaticobiliary maljunction. Controversy remains in regard to the theory of carcinogenesis from adenomyomatosis, porcelain gallbladder and adenoma of the gallbladder. The surgical strategy and prognosis after surgery for GBC differ strikingly according to T-stage. Discrimination of favorable cases, particularly T2 or T3 lesions, is useful for the selection of surgical strategies for individual patients. Although many candidate factors predicting disease progression, such as depth of subserosal invasion, horizontal tumor spread, tumor budding, dedifferentiation, Ki-67 labeling index, p53 nuclear expression, CD8+ tumor-infiltrating lymphocytes, mitotic counts, Laminin-5-gamma-2 chain, hypoxia-inducible factor-1a, cyclooxygenase-2 and the Hedgehog signaling pathway have been investigated,useful prognostic makers or factors have not been established. As GBC is often discovered incidentally after routine cholecystectomy and accurate preoperative diagnosis is difficult, close mutual cooperation between surgeons and pathologists is essential for developing a rational surgical strategy for GBC.

Remolded Undrained Strength of Soils

Extensive data of undrained shear strength for various remolded soils are compiled to normalize the remolded undrained strength. Remolded soils have a wide spectrum of liquid limits ranging from 25% to 412%. It is found that the remolded undrained strength is a function of water content and liquid limit. Furthermore, a simple index designated as normalized water content w * is introduced for normalizing remolded undrained strength for various soils. The normalized water content w * is the ratio of water content to liquid limit. The relationship between the remolded undrained strength and the normalized water content can be expressed by a simple equation. The new simple equation is not only valuable theoretically for helping in assessing the in situ mechanical behavior, but also useful to ocean engineering practice.

Rational therapeutic strategy for T2 gallbladder carcinoma based on tumor spread

AIM:To evaluate the adequacy of surgical treatment of T2 gallbladder carcinoma(GBCa)according to tumor spread in the subserosal layer. METHODS:A series of 84 patients with GBCa were treated at Saga University Hospital,Japan between April 1989 and October 2008.The tumor stage was graded according to the TNM staging for GBCa from the American Joint Committee on Cancer Manual 6th edition. Tumor staging revealed 30 patients with T2 tumors.T2 GBCa was divided into three groups histologically by the extent of tumor spread in the subserosal layer,using a score of ss minimum(ss min),ss medium(ss med)or ss massive(ss mas). RESULTS:For ss min GBCa,there was no positive pathological factor and patient survival was satisfactory with simple cholecystectomy,with or without extra-he- patic bile duct resection.For ss med GBCa,some pathological factors,h-inf(hepatic infiltration),ly(lymphatic invasion)and n(lymph node metastasis),were positive. For ss mas GBCa,there was a high incidence of positive pathological factors.The patient group with extra-hepatic bile duct resection with D2 lymph node dissection (BDR with D2)and those with S4a5 hepatectomy had significantly better survival rates.CONCLUSION:We suggest that radical surgery is not necessary for ss min GBCa,and partial hepatectomy and BDR are necessary for both ss med and ss mas GBCa.

Survival of pathogenic bacteria in compost with special reference to Escherichia coli

Application of compost in agricultural practice could potentially cause contamination of foodstuffs with pathogenic bacteria such as Escherichia coli O157：H7 （E. Coli O157）. We investigated pathogenic bacteria in compost collected from the compost facilities, and evaluated the survival of E. coli K12 and O157 in laboratory experiments. Out of 19 compost product samples, coliform bacteria and salmonella were detected in 7 and 3 samples respectively. The number of coliform bacteria was 1.8 × 10^2 to 2.5 × 10^6 CFU/g dw and that of salmonella was 4.2 × 10^1 to 6.0 × 10^3 CFU/g dw. Moreover. coliform bacteria, fecal coliform, E. coli and salmonella were detected during composting at 54℃ to 67℃. The results indicated that moisture content was a very important factor to the heat sensitivity of pathogenic bacteria in compost, E. coli in compost of high moisture content was more sensitive than that in compost of low moisture content, cells harvested in logarithmic phase was more sensitive than these in stationary phase, and E. coli K12 was more sensitive than E. coli O157. Based on the D values, the lethal time of E. coli K12 and 0157 from 10^8 to 10^0 CFU/g dw were 16.3 and 28.8 min, respectively, at 60℃ in compost with 40% moisture content. However, some E. coli cells survived in composting process at 54℃ to 67℃. Water potential（low moisture content） and physiological aspects of bacteria（stationary phase） could explain only in part of the prolonged survival of E. coli in compost, and there should be some other factors that are conducive to bacterial survial in compost.