The antitumor efficiency of gold nanorod plasmonic photothermal therapy(PPTT)was evalu-ated experimentally.The rat cholangiocarcinoma line PC-1 was used as a tumor model.Exposureof tumors to S08-nm laser radiation was...The antitumor efficiency of gold nanorod plasmonic photothermal therapy(PPTT)was evalu-ated experimentally.The rat cholangiocarcinoma line PC-1 was used as a tumor model.Exposureof tumors to S08-nm laser radiation was performed,and the noninvasive temperature monitoring of the tumor tissue was carried out using infrared imager.The growth rate kinetics and mor-phological alterations of transplanted liver tumors,as wll as indicators of lipid peroxidation activity and autointoxication in rat serum,were studied,The activation of lipid peroxidation andthe development of autointoxication were detected after PPTT.The results not only demonstratethe antitumor ficacy of the proposed therapeutic technology but also reveal the side effectsin the presence of peroxidation products in systemic circulation.展开更多
Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther apy.The prolonged peroral administr...Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther apy.The prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory animals.In this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after administration.After the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle size.Specifically,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative changes.Most importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.展开更多
基金supported by a grant No.14-13-01167 from the Russian Scientic Foundationsupported by the Russian Presidential grant NSh-703.2014.2 (ANB,EAG and VVT)by ABB,GNM and GST was supported by a grant No.14.Z50.31.0004 to support scientic research projects implemented under the supervision of leading scientists at Russian institutions of higher education.
文摘The antitumor efficiency of gold nanorod plasmonic photothermal therapy(PPTT)was evalu-ated experimentally.The rat cholangiocarcinoma line PC-1 was used as a tumor model.Exposureof tumors to S08-nm laser radiation was performed,and the noninvasive temperature monitoring of the tumor tissue was carried out using infrared imager.The growth rate kinetics and mor-phological alterations of transplanted liver tumors,as wll as indicators of lipid peroxidation activity and autointoxication in rat serum,were studied,The activation of lipid peroxidation andthe development of autointoxication were detected after PPTT.The results not only demonstratethe antitumor ficacy of the proposed therapeutic technology but also reveal the side effectsin the presence of peroxidation products in systemic circulation.
基金supported by Grant No.14-13-01167 from the Russian Scientic Foundation.The morphological studies done by GNM,SSP,OVZ,IOB and NAN were conducted by the state task of Russian ministry of Health.The work done by VVT on interpretation of experimental data was supported by Grant No.14-15-00186 of the Russian Science Foundation.
文摘Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther apy.The prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory animals.In this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after administration.After the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle size.Specifically,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative changes.Most importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.
