Objective Neighbourhood deprivation increases the risk of colorectal neoplasia and contributes to racial disparities observed in this disease.Developing race-specific advanced colorectal neoplasia(ACN)prediction model...Objective Neighbourhood deprivation increases the risk of colorectal neoplasia and contributes to racial disparities observed in this disease.Developing race-specific advanced colorectal neoplasia(ACN)prediction models that include neighbourhood socioeconomic status has the potential to improve the accuracy of prediction.Methods The study includes 1457 European Americans(EAs)and 936 African Americans(AAs)aged 50–80 years undergoing screening colonoscopy.Race-specific ACN risk prediction models were developed for EAs and AAs,respectively.Area Deprivation Index(ADI),derived from 17 variables of neighbourhood socioeconomic status,was evaluated by adding it to the ACN risk prediction models.Prediction accuracy was evaluated by concordance statistic(C-statistic)for discrimination and Hosmer-Lemeshow goodness-of-fit test for calibration.Results With fewer predictors,the EA-specific and AA-specific prediction models had better prediction accuracy in the corresponding race/ethnic subpopulation than the overall model.Compared with the overall model which had poor calibration(P_(Calibration)=0.053 in the whole population and P_(Calibration)=0.011 in AAs),the EA model had C-statistic of 0.655(95%CI 0.594 to 0.717)and P_(Calibration)=0.663;and the AA model had C-statistic of 0.637((95%CI 0.572 to 0.702)and P_(Calibration)=0.810.ADI was a significant predictor of ACN in EAs(OR=1.24((95%CI 1.03 to 1.50),P=0.029),but not in AAs(OR=1.07((95%CI 0.89 to 1.28),P=0.487).Adding ADI to the EA-specific ACN prediction model substantially improved ACN calibration accuracy of the prediction across area deprivation groups(P_(Calibration)=0.924 with ADI vs P_(Calibration)=0.140 without ADI)in EAs.Conclusions Neighbourhood socioeconomic status is an important factor to consider in ACN risk prediction modeling.Moreover,non-race-specific prediction models have poor generalisability.Race-specific prediction models incorporating neighbourhood socioeconomic factors are needed to improve ACN prediction accuracy.展开更多
Objective:This study describes strategies used by federally qualified health centers(FQHCs)to assist medically uninsured patients in obtaining specialty health care services.Methods:Qualitative methods were used to st...Objective:This study describes strategies used by federally qualified health centers(FQHCs)to assist medically uninsured patients in obtaining specialty health care services.Methods:Qualitative methods were used to study strategies for obtaining specialty health care for uninsured patients.Data were gathered from 10 primary care clinicians at three FQHC clinics by means of 10 semistructured interviews,23 brief interviews,and 45 h of direct observations.We captured additional data by studying cases of referred uninsured patients.Results:The following six strategies were identified:(1)quid pro quo-a specialist accept-ing the clinic’s medically uninsured patients was rewarded with referrals of the clinic’s insured patients;(2)over referral-clinicians referred insured patients whose needs could have been met at the FQHC;(3)brief hospitalization-when a specialist could not be obtained,high-risk patients were briefly hospitalized;(4)case building-diagnostic tests were conducted at the FQHC to justify a referral;(5)direct communication-communication between clinicians and specialists was neces-sary when requesting a referral;(6)specialty clinics-in return for conducting a specialty clinic at the FQHC,the specialist received all referrals of insured patients.Conclusion:Uninsured FQHC patients encountered difficulties accessing specialty health care,and in response,clinicians developed a range of innovative strategies.展开更多
基金supported by Cancer Disparities Grants from National Cancer Institute(P20 CA2332160R21CA283132).
文摘Objective Neighbourhood deprivation increases the risk of colorectal neoplasia and contributes to racial disparities observed in this disease.Developing race-specific advanced colorectal neoplasia(ACN)prediction models that include neighbourhood socioeconomic status has the potential to improve the accuracy of prediction.Methods The study includes 1457 European Americans(EAs)and 936 African Americans(AAs)aged 50–80 years undergoing screening colonoscopy.Race-specific ACN risk prediction models were developed for EAs and AAs,respectively.Area Deprivation Index(ADI),derived from 17 variables of neighbourhood socioeconomic status,was evaluated by adding it to the ACN risk prediction models.Prediction accuracy was evaluated by concordance statistic(C-statistic)for discrimination and Hosmer-Lemeshow goodness-of-fit test for calibration.Results With fewer predictors,the EA-specific and AA-specific prediction models had better prediction accuracy in the corresponding race/ethnic subpopulation than the overall model.Compared with the overall model which had poor calibration(P_(Calibration)=0.053 in the whole population and P_(Calibration)=0.011 in AAs),the EA model had C-statistic of 0.655(95%CI 0.594 to 0.717)and P_(Calibration)=0.663;and the AA model had C-statistic of 0.637((95%CI 0.572 to 0.702)and P_(Calibration)=0.810.ADI was a significant predictor of ACN in EAs(OR=1.24((95%CI 1.03 to 1.50),P=0.029),but not in AAs(OR=1.07((95%CI 0.89 to 1.28),P=0.487).Adding ADI to the EA-specific ACN prediction model substantially improved ACN calibration accuracy of the prediction across area deprivation groups(P_(Calibration)=0.924 with ADI vs P_(Calibration)=0.140 without ADI)in EAs.Conclusions Neighbourhood socioeconomic status is an important factor to consider in ACN risk prediction modeling.Moreover,non-race-specific prediction models have poor generalisability.Race-specific prediction models incorporating neighbourhood socioeconomic factors are needed to improve ACN prediction accuracy.
基金the Clinical and Translational Science Collaborative of Cleveland,UL1TR000439 from the National Center for Advancing Translational Sciences component of the National Institutes of Health(NIH)the NIH Roadmap for Medical Research,by Case Comprehensive Cancer Center Support Grant P30CA43703-23 from the National Cancer Institute of the NIH,and by the Centers for Primary Care Practice-Based Research and Learning from the Agency for Healthcare Research and Quality through grant P30HS021648-03.
文摘Objective:This study describes strategies used by federally qualified health centers(FQHCs)to assist medically uninsured patients in obtaining specialty health care services.Methods:Qualitative methods were used to study strategies for obtaining specialty health care for uninsured patients.Data were gathered from 10 primary care clinicians at three FQHC clinics by means of 10 semistructured interviews,23 brief interviews,and 45 h of direct observations.We captured additional data by studying cases of referred uninsured patients.Results:The following six strategies were identified:(1)quid pro quo-a specialist accept-ing the clinic’s medically uninsured patients was rewarded with referrals of the clinic’s insured patients;(2)over referral-clinicians referred insured patients whose needs could have been met at the FQHC;(3)brief hospitalization-when a specialist could not be obtained,high-risk patients were briefly hospitalized;(4)case building-diagnostic tests were conducted at the FQHC to justify a referral;(5)direct communication-communication between clinicians and specialists was neces-sary when requesting a referral;(6)specialty clinics-in return for conducting a specialty clinic at the FQHC,the specialist received all referrals of insured patients.Conclusion:Uninsured FQHC patients encountered difficulties accessing specialty health care,and in response,clinicians developed a range of innovative strategies.