To accomplish their functions, proteins have to achieve different conformations accompanied by conformational transitions. However, the relationship between the preference of amino acids and the stability of the secon...To accomplish their functions, proteins have to achieve different conformations accompanied by conformational transitions. However, the relationship between the preference of amino acids and the stability of the secondary structure is still unclear. Here we perform molecular simulations on a series of helical structures. Our data show that the dissociation energy of the helical structure is related to the preference of amino acids, and the electrostatic repulsion of the residue i and i ＋ 3/4 with the same sign of charge destabilizes the alpha helix.展开更多
Under the guidance of the “the Belt and Road” policy, the academic community continues to study the historical relics of the western regions and military facilities along the silk road in recent years. Focusing on t...Under the guidance of the “the Belt and Road” policy, the academic community continues to study the historical relics of the western regions and military facilities along the silk road in recent years. Focusing on the military defense buildings in the western regions of the Han and Tang Dynasties, CiteSpace software is used to conduct statistical and visual analysis on the hot issues of relevant literature in the military buildings on the silk road. Based on the analysis of frontier hot issues, the research trend of future topics is analyzed and predicted. The research shows that the frontier hot spots of military architecture in the western regions of Han and Tang Dynasties are extensive, and the research trend is steadily rising.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 11247010,11175055,11475053 and 11347017the Natural Science Foundation for Distinguished Young Scholars of Hebei Province under Grant No C2015202340+1 种基金the Natural Science Foundation of Hebei Province under Grant Nos C2012202079 and C201400305the Scientific Innovation Fund for Excellent Young Scientists of Hebei University of Technology under Grant No 2015010
文摘To accomplish their functions, proteins have to achieve different conformations accompanied by conformational transitions. However, the relationship between the preference of amino acids and the stability of the secondary structure is still unclear. Here we perform molecular simulations on a series of helical structures. Our data show that the dissociation energy of the helical structure is related to the preference of amino acids, and the electrostatic repulsion of the residue i and i ＋ 3/4 with the same sign of charge destabilizes the alpha helix.
文摘Under the guidance of the “the Belt and Road” policy, the academic community continues to study the historical relics of the western regions and military facilities along the silk road in recent years. Focusing on the military defense buildings in the western regions of the Han and Tang Dynasties, CiteSpace software is used to conduct statistical and visual analysis on the hot issues of relevant literature in the military buildings on the silk road. Based on the analysis of frontier hot issues, the research trend of future topics is analyzed and predicted. The research shows that the frontier hot spots of military architecture in the western regions of Han and Tang Dynasties are extensive, and the research trend is steadily rising.
