US Latinos experience higher rates of obesity than their non-Latino counterparts. Factors associated with immigration, including length of residence in the United States, are associated with an increased risk of obesi...US Latinos experience higher rates of obesity than their non-Latino counterparts. Factors associated with immigration, including length of residence in the United States, are associated with an increased risk of obesity. Latino community health workers (CHWs) work closely with communities, and are in an ideal position to provide insight on the underlying mechanisms of the Latino obesity epidemic. Focus groups were conducted with 15 CHWs and thematic analyses were performed to explore elements associated with obesity among Latino immigrants. Emergent themes included: reduction in physical activity due to less walkable spaces, more transportation options, and busier schedules in the United States. Interviewees also identified a sudden increase in access to unhealthy food and an abrupt reduction in access to, and affordability of, healthy food choices upon immigration. Culturally appropriate interventions to increase awareness of these factors and neutralize their effects among early Latino immigrants are recommended.展开更多
A long-term vegetarian diet plays a role in the longevity and maintenance of the healthspan,but the underlying mechanisms for these observations are largely unknown.Particularly,it is not known whether a longterm vege...A long-term vegetarian diet plays a role in the longevity and maintenance of the healthspan,but the underlying mechanisms for these observations are largely unknown.Particularly,it is not known whether a longterm vegetarian dietary pattern may affect the circulating miRNA expression in such a way as to modulate the healthspan.The Adventist Health Study-2(AHS-2)cohort includes a large number of older adults who primarily follow vegetarian dietary patterns and reside in Loma Linda,California,one of five“Blue Zones”in the world in which a higher proportion of the population enjoys a longer than average lifespan.We performedmiRNA-seq in 96 subjects selected from the AHS-2 cohort with different dietary patterns.We identified several differentially expressed miRNAs between vegetarians and non-vegetarians,which are involved in immune response and cytokine signaling,cell growth and proliferation as well as age-related diseases such as cardiovascular diseases and neurodegenerative diseases.Overall,our study showed that a vegetarian diet modulates aging-associated circulating miRNAs in a sex-dependent manner of differential expression for certain miRNAs,which may be related in a beneficial manner to the healthspan.Further investigation is needed to validate these miRNAs as potential biomarkers for diet-modulated longevity in humans.展开更多
文摘US Latinos experience higher rates of obesity than their non-Latino counterparts. Factors associated with immigration, including length of residence in the United States, are associated with an increased risk of obesity. Latino community health workers (CHWs) work closely with communities, and are in an ideal position to provide insight on the underlying mechanisms of the Latino obesity epidemic. Focus groups were conducted with 15 CHWs and thematic analyses were performed to explore elements associated with obesity among Latino immigrants. Emergent themes included: reduction in physical activity due to less walkable spaces, more transportation options, and busier schedules in the United States. Interviewees also identified a sudden increase in access to unhealthy food and an abrupt reduction in access to, and affordability of, healthy food choices upon immigration. Culturally appropriate interventions to increase awareness of these factors and neutralize their effects among early Latino immigrants are recommended.
基金The genomic work carried out at the Loma Linda University Center for Genomics were funded in part by the National Institutes of Health(NIH)(Grant No.S10OD019960)(CW)This project is partially supported by the American Heart Association(AHA)(Grant No.18IPA34170301)(CW)+1 种基金and also partially supported by NIH(Grants No.HL115195-06(HQ)/subcontract(GSU)#SP00013920-02(CW),and HL137962(HQ)/subcontract(GSU)#SP00013696-01(CW))Subject recruitment and blood collection were partially funded by the LLU Grants for Research and School Partnerships(GRASP)2140309(NG&GL).
文摘A long-term vegetarian diet plays a role in the longevity and maintenance of the healthspan,but the underlying mechanisms for these observations are largely unknown.Particularly,it is not known whether a longterm vegetarian dietary pattern may affect the circulating miRNA expression in such a way as to modulate the healthspan.The Adventist Health Study-2(AHS-2)cohort includes a large number of older adults who primarily follow vegetarian dietary patterns and reside in Loma Linda,California,one of five“Blue Zones”in the world in which a higher proportion of the population enjoys a longer than average lifespan.We performedmiRNA-seq in 96 subjects selected from the AHS-2 cohort with different dietary patterns.We identified several differentially expressed miRNAs between vegetarians and non-vegetarians,which are involved in immune response and cytokine signaling,cell growth and proliferation as well as age-related diseases such as cardiovascular diseases and neurodegenerative diseases.Overall,our study showed that a vegetarian diet modulates aging-associated circulating miRNAs in a sex-dependent manner of differential expression for certain miRNAs,which may be related in a beneficial manner to the healthspan.Further investigation is needed to validate these miRNAs as potential biomarkers for diet-modulated longevity in humans.
