Amyotrophic lateral sclerosis（ALS）is a rapidly progressive disorder characterized by the degeneration and subsequent loss of upper and lower motor neurons,resulting in reduced muscle function and paralysis（Mathis e...Amyotrophic lateral sclerosis（ALS）is a rapidly progressive disorder characterized by the degeneration and subsequent loss of upper and lower motor neurons,resulting in reduced muscle function and paralysis（Mathis et al.,2017）.Current therapies are limited to the oral administration of riluzole,which improves survival by only 3 months（Mathis et al.,2017）.Thus,展开更多
基金supported by the MND Research Institute of Australia and the Stanford Family MND Research Grantsupported by the National Health and Medical Research Council of AustraliaUS Department of Defense Therapeutic Ideas Grant
文摘Amyotrophic lateral sclerosis（ALS）is a rapidly progressive disorder characterized by the degeneration and subsequent loss of upper and lower motor neurons,resulting in reduced muscle function and paralysis（Mathis et al.,2017）.Current therapies are limited to the oral administration of riluzole,which improves survival by only 3 months（Mathis et al.,2017）.Thus,
