Infectious diseases pose a serious threat to global health.Although immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates...Infectious diseases pose a serious threat to global health.Although immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates of illness and death.Unfortunately,the creation of new antibiotics has come to a grinding halt in the last ten years.In response to this crisis,nanotechnology has emerged as a hopeful solution to tackle drug resistance and enhance treatment results.A large variety of biomimetic nanomaterials,termed nanozymes,have demonstrated strong antimicrobial efficacy.While the inherent toxicity of nanomaterials is a concern,recent studies have harnessed the stimuli-responsiveness of nanomaterials to enable local and/or targeted delivery to reduce the treatment side effects.Indeed,the physicochemical versatility of nanomaterials affords many degrees of freedom that enable rational design of smart or autonomous therapeutics,which cannot be achieved using conventional antibiotics.The design straddles the fields of catalysis,nanoscience,microbiology,and translational medicine.To provide an overview of this interdisciplinary landscape,this review is organized based on composition into lipid,metal,metal oxide,and non-metallic nanomaterials.Liposomes as a delivery vehicle enhance bioavailability and reduce toxicity.Metal-and metal oxide-based nanomaterials inhibit bacterial growth by mimicking natural enzymatic activities such as peroxidase(POD)and oxidase.Furthermore,carbon-,polymer-,and cell membrane-based nanomaterials are combined into a discussion on non-metallic materials.At the end of this review,potentially fruitful directions for future bioinspired nanomaterials in infectious disease treatment are included.展开更多
The enormous number of combinations of adsorbing molecules and porous materials that exist is known as adsorption space.The adsorption space for microporous polymers has not yet been systematically explored,especially...The enormous number of combinations of adsorbing molecules and porous materials that exist is known as adsorption space.The adsorption space for microporous polymers has not yet been systematically explored,especially when compared with efforts for crystalline adsorbents.We report molecular simulation data for the adsorptive and structural properties of polymers of intrinsic microporosity with a diverse set of adsorbate species with 345 distinct adsorption isotherms and over 240,000 fresh and swollen structures.These structures and isotherms were obtained using a sorption-relaxation technique that accounts for the critical role of flexibility of the polymeric adsorbents.This enables us to introduce a set of correlations that can estimate adsorbent swelling and fractional free volume dilation as a function of adsorbate uptake based on readily characterized properties.The separation selectivity of the 276 distinct binary molecular pairs in our data is reported and high-performing adsorbent systems are identified.展开更多
基金supported by the Department of Defense,Office of Naval Research(ONR award N00014-20-1-2418)National Institutes of Health,National Institute on Deafness and Other Communication Disorders(NIHDC016644).
文摘Infectious diseases pose a serious threat to global health.Although immunizations can control most viral infections,bacterial infections,particularly those caused by drug-resistant strains,continue to cause high rates of illness and death.Unfortunately,the creation of new antibiotics has come to a grinding halt in the last ten years.In response to this crisis,nanotechnology has emerged as a hopeful solution to tackle drug resistance and enhance treatment results.A large variety of biomimetic nanomaterials,termed nanozymes,have demonstrated strong antimicrobial efficacy.While the inherent toxicity of nanomaterials is a concern,recent studies have harnessed the stimuli-responsiveness of nanomaterials to enable local and/or targeted delivery to reduce the treatment side effects.Indeed,the physicochemical versatility of nanomaterials affords many degrees of freedom that enable rational design of smart or autonomous therapeutics,which cannot be achieved using conventional antibiotics.The design straddles the fields of catalysis,nanoscience,microbiology,and translational medicine.To provide an overview of this interdisciplinary landscape,this review is organized based on composition into lipid,metal,metal oxide,and non-metallic nanomaterials.Liposomes as a delivery vehicle enhance bioavailability and reduce toxicity.Metal-and metal oxide-based nanomaterials inhibit bacterial growth by mimicking natural enzymatic activities such as peroxidase(POD)and oxidase.Furthermore,carbon-,polymer-,and cell membrane-based nanomaterials are combined into a discussion on non-metallic materials.At the end of this review,potentially fruitful directions for future bioinspired nanomaterials in infectious disease treatment are included.
基金This work was supported by the U.S.Department of Energy,Office of Science,Basic Energy Sciences,under Award DE-FG02-17ER16362as part of the ComputationalChemical Sciences Program.Simulations were carried out on the University of Florida's high-performance computing system HiPerGator 2.0.
文摘The enormous number of combinations of adsorbing molecules and porous materials that exist is known as adsorption space.The adsorption space for microporous polymers has not yet been systematically explored,especially when compared with efforts for crystalline adsorbents.We report molecular simulation data for the adsorptive and structural properties of polymers of intrinsic microporosity with a diverse set of adsorbate species with 345 distinct adsorption isotherms and over 240,000 fresh and swollen structures.These structures and isotherms were obtained using a sorption-relaxation technique that accounts for the critical role of flexibility of the polymeric adsorbents.This enables us to introduce a set of correlations that can estimate adsorbent swelling and fractional free volume dilation as a function of adsorbate uptake based on readily characterized properties.The separation selectivity of the 276 distinct binary molecular pairs in our data is reported and high-performing adsorbent systems are identified.
