Petri net(PN) is one of the promising computational and mathematical formalisms used to represent and study the behavior of complex metabolic networks. The various available analysis techniques of PN could be used to ...Petri net(PN) is one of the promising computational and mathematical formalisms used to represent and study the behavior of complex metabolic networks. The various available analysis techniques of PN could be used to validate and analyze the network in different scenarios. Plasmodium falciparum is one of the threatening parasites which causes malaria, a deadly disease affecting a large number of today’s world population. The development of antimalarial drug resistance is an emerging global threat, highlighting the need to discover novel antimalarial targets. The fatty acid biosynthesis of malarial parasite is one of the essential metabolic pathways required for its growth and is present in apicoplast, a non-photosynthetic plastid. The malarial parasite obtains fatty acids by using type two fatty acid synthase(FAS II) enzyme,which is different from type one enzyme used by human host, making it an ideal drug target.This article proposes and studies the PN model of the parasite’s FAS II pathway to analyze the mechanism of potential drug targets in this pathway. The proposed PN model can serve as a base for further findings in the field of antimalarial drug targets to decrease the malaria mortality rate.展开更多
Manipuri traditional game Kei-Yen, which originates from the ancient Meitei mythological story, is a mind game between two players of different mindsets, one has the mindset of killing (Kei), whereas the other (Yen) h...Manipuri traditional game Kei-Yen, which originates from the ancient Meitei mythological story, is a mind game between two players of different mindsets, one has the mindset of killing (Kei), whereas the other (Yen) has the mindset of protecting itself and block the moves of Kei. We propose and develop an algorithm of this game by incorporating various possible logical tactics and strategies for a possible computer software of this game. Since this game involves various logical mind games, playing this game can improve our way of thinking, strategies, tricks and other skills related to mind game. In this play there is not the case of draw which means one has to win over the other at the end of the game. This game could become one of most interesting indoor national or international game.展开更多
Monte Carlo simulation of paths of a large number of impinging electrons in a multi-layered solid allows defining area of spreading electrons (A) to capture overall behavior of the solid. This parameter “A” follows ...Monte Carlo simulation of paths of a large number of impinging electrons in a multi-layered solid allows defining area of spreading electrons (A) to capture overall behavior of the solid. This parameter “A” follows power law with electron energy. Furthermore, change in critical energies, which are minimum energies loses corresponding to various electrons, as a function of variation in lateral distance also follows power law nature. This power law behavior could be an indicator of how strong self-organization a solid has which may be used in monitoring efficiency of device fabrication.展开更多
基金Supported by the Science and Engineering Research Board(SERB)。
文摘Petri net(PN) is one of the promising computational and mathematical formalisms used to represent and study the behavior of complex metabolic networks. The various available analysis techniques of PN could be used to validate and analyze the network in different scenarios. Plasmodium falciparum is one of the threatening parasites which causes malaria, a deadly disease affecting a large number of today’s world population. The development of antimalarial drug resistance is an emerging global threat, highlighting the need to discover novel antimalarial targets. The fatty acid biosynthesis of malarial parasite is one of the essential metabolic pathways required for its growth and is present in apicoplast, a non-photosynthetic plastid. The malarial parasite obtains fatty acids by using type two fatty acid synthase(FAS II) enzyme,which is different from type one enzyme used by human host, making it an ideal drug target.This article proposes and studies the PN model of the parasite’s FAS II pathway to analyze the mechanism of potential drug targets in this pathway. The proposed PN model can serve as a base for further findings in the field of antimalarial drug targets to decrease the malaria mortality rate.
文摘Manipuri traditional game Kei-Yen, which originates from the ancient Meitei mythological story, is a mind game between two players of different mindsets, one has the mindset of killing (Kei), whereas the other (Yen) has the mindset of protecting itself and block the moves of Kei. We propose and develop an algorithm of this game by incorporating various possible logical tactics and strategies for a possible computer software of this game. Since this game involves various logical mind games, playing this game can improve our way of thinking, strategies, tricks and other skills related to mind game. In this play there is not the case of draw which means one has to win over the other at the end of the game. This game could become one of most interesting indoor national or international game.
文摘Monte Carlo simulation of paths of a large number of impinging electrons in a multi-layered solid allows defining area of spreading electrons (A) to capture overall behavior of the solid. This parameter “A” follows power law with electron energy. Furthermore, change in critical energies, which are minimum energies loses corresponding to various electrons, as a function of variation in lateral distance also follows power law nature. This power law behavior could be an indicator of how strong self-organization a solid has which may be used in monitoring efficiency of device fabrication.
