Soft matter refers to a class of materials that can be easily deformed,either by small forces or by thermal energy.These materials generally have both solid-like and liquid-like behaviors.They are typically characteri...Soft matter refers to a class of materials that can be easily deformed,either by small forces or by thermal energy.These materials generally have both solid-like and liquid-like behaviors.They are typically characterized by some elastic coefficient whose value is many orders of magnitude less than most solids.The unit of an elastic constant is pressure or energy density.The energies that characterize materials can vary by a few orders of magnitude,from thermal energies to several electron volts,the latter of which characterize a strong covalent bond.However,the elastic coefficients of soft materials can be as much as ten orders of magnitude less than those of solids.This range must reflect a change in the length scale or the density term.Thus,the fundamental physics of soft matter always occurs at larger length scales,and it is the study of these larger length scales that gives the field its great fascination.展开更多
Alzheimer’s disease(AD)is a neurodegenerative disorder,and the etiology of AD has not been completely elucidated.It remains unknown how the components from the brain’s extracellular matrix(ECM),particularly fibrous ...Alzheimer’s disease(AD)is a neurodegenerative disorder,and the etiology of AD has not been completely elucidated.It remains unknown how the components from the brain’s extracellular matrix(ECM),particularly fibrous entities,may influence the pathogenesis of AD.Herein,we report that treatment with elastin-like polypeptides(ELPs),a component of the brain ECM,significantly increases the extracellular levels of AD-related amyloid-beta(Aβ)peptides and decreases intracellular Aβlevels in human microglial cell model HMC3 cells(HMC3).展开更多
文摘Soft matter refers to a class of materials that can be easily deformed,either by small forces or by thermal energy.These materials generally have both solid-like and liquid-like behaviors.They are typically characterized by some elastic coefficient whose value is many orders of magnitude less than most solids.The unit of an elastic constant is pressure or energy density.The energies that characterize materials can vary by a few orders of magnitude,from thermal energies to several electron volts,the latter of which characterize a strong covalent bond.However,the elastic coefficients of soft materials can be as much as ten orders of magnitude less than those of solids.This range must reflect a change in the length scale or the density term.Thus,the fundamental physics of soft matter always occurs at larger length scales,and it is the study of these larger length scales that gives the field its great fascination.
基金from National Key R&D Program of China(grant no.2018YFA0902600)the Scientific Instrument Developing Project of the Chinese Academy of Sciences(grant no.ZDKYYQ20180001)+1 种基金the Jilin Province Science Fund for Excellent Young Scholars(20190103072JH),K.C.Wong Education Foundation(grant no.GJTD-2018-09)and the National Natural Science Foundation of China(grant nos.21704099,21877104,and 21834007)and the Cure Alzheimer’s Fund.
文摘Alzheimer’s disease(AD)is a neurodegenerative disorder,and the etiology of AD has not been completely elucidated.It remains unknown how the components from the brain’s extracellular matrix(ECM),particularly fibrous entities,may influence the pathogenesis of AD.Herein,we report that treatment with elastin-like polypeptides(ELPs),a component of the brain ECM,significantly increases the extracellular levels of AD-related amyloid-beta(Aβ)peptides and decreases intracellular Aβlevels in human microglial cell model HMC3 cells(HMC3).
