Malnutrition is present in the majority of patients presenting for surgical management of gastrointestinal malignancies,due to the effects of the tumour and preoperative anti-neoplastic treatments.The traditional prac...Malnutrition is present in the majority of patients presenting for surgical management of gastrointestinal malignancies,due to the effects of the tumour and preoperative anti-neoplastic treatments.The traditional practice of fasting patients until the resumption of bowel function threatens to further contribute to the malnutrition experienced by these patients.Furthermore,the rationale behind this traditional practice has been rendered obsolete through developments in anaesthetic agents and changes to postoperative analgesia practices.Conversely,there is a growing body of literature that consistently demonstrates that providing oral or tube feeding proximal to the anastomosis within 24 h postoperatively,is not only safe,but might be associated with significant benefits to the postoperative course.Early post operative feeding should therefore be adopted as a standard of care in oncology patients undergoing gastrointestinal resections.展开更多
Objective:To investigate the biochemical relationship between follicular/oocyte maturity and follicular inhibins and activin levels. Design:Prospective study. Setting:Research laboratory in university hospital. Patien...Objective:To investigate the biochemical relationship between follicular/oocyte maturity and follicular inhibins and activin levels. Design:Prospective study. Setting:Research laboratory in university hospital. Patient(s):Thirty-five women undertook IVF/ICSI program. Intervention(s):Individual follicular fluid aspirations,oocyte isolation,follicular fluid storage. Main Outcome Measure(s):Inhibin A,inhibin B,and activinAconcentrations,oocyte retrieval,and fertility outcome. Result(s):Inhibin A,inhibin B,and activin A concentrations varied from 7.9 to 436 ng/mL,9.7 to 786 ng/mL,and 1.7 to 267.9 ng/mL,respectively. There was no change of inhibin A concentrations,whereas inhibin B and activin A concentrations dropped dramatically as the follicles enlarged. Total follicular content of inhibin A and activin A increased,and inhibin B remained constant. Both inhibin A and inhibin B levels were significantly higher in those follicles from which an oocyte could be recovered,but they did not differ with respect to subsequent oocyte fertilization. Conclusion(s):Inhibin A is actively produced throughout follicular growth to retain a set concentration. In contrast,inhibin B appears not to be actively produced,and the concentration drops as follicles enlarge. Activin A concentrations also decrease,but there is some extra synthesis. Higher levels of inhibin A and B are associated with oocyte presence but not with fertilization rates.展开更多
文摘Malnutrition is present in the majority of patients presenting for surgical management of gastrointestinal malignancies,due to the effects of the tumour and preoperative anti-neoplastic treatments.The traditional practice of fasting patients until the resumption of bowel function threatens to further contribute to the malnutrition experienced by these patients.Furthermore,the rationale behind this traditional practice has been rendered obsolete through developments in anaesthetic agents and changes to postoperative analgesia practices.Conversely,there is a growing body of literature that consistently demonstrates that providing oral or tube feeding proximal to the anastomosis within 24 h postoperatively,is not only safe,but might be associated with significant benefits to the postoperative course.Early post operative feeding should therefore be adopted as a standard of care in oncology patients undergoing gastrointestinal resections.
文摘Objective:To investigate the biochemical relationship between follicular/oocyte maturity and follicular inhibins and activin levels. Design:Prospective study. Setting:Research laboratory in university hospital. Patient(s):Thirty-five women undertook IVF/ICSI program. Intervention(s):Individual follicular fluid aspirations,oocyte isolation,follicular fluid storage. Main Outcome Measure(s):Inhibin A,inhibin B,and activinAconcentrations,oocyte retrieval,and fertility outcome. Result(s):Inhibin A,inhibin B,and activin A concentrations varied from 7.9 to 436 ng/mL,9.7 to 786 ng/mL,and 1.7 to 267.9 ng/mL,respectively. There was no change of inhibin A concentrations,whereas inhibin B and activin A concentrations dropped dramatically as the follicles enlarged. Total follicular content of inhibin A and activin A increased,and inhibin B remained constant. Both inhibin A and inhibin B levels were significantly higher in those follicles from which an oocyte could be recovered,but they did not differ with respect to subsequent oocyte fertilization. Conclusion(s):Inhibin A is actively produced throughout follicular growth to retain a set concentration. In contrast,inhibin B appears not to be actively produced,and the concentration drops as follicles enlarge. Activin A concentrations also decrease,but there is some extra synthesis. Higher levels of inhibin A and B are associated with oocyte presence but not with fertilization rates.
