A Study on Integrated Construction of Luzhou Comprehensive Transportation Hub

The target of integrated construction of comprehensive transportation hub is to integrate the traffic resources,achieve butt joint of pan-regional transportation mode,and finally realize the"seamless connection"of the goods and"zero transfer"of the passenger traffic.Relying on the particularity of the geographical location and the convenience of the Yangtze River channel,Luzhou puts forth effort to build a comprehensive transport hub in Southern Sichuan and has made great efforts in traffic infrastructure construction.However,there are still some problems.Combining practice of Luzhou,using the advanced experience of foreign and domestic cities for reference,the paper pointed out that for the sake of constructing a comprehensive transportation hub,we need to build the traffic integration on the basis of the efficiency.Besides,the paper proposed the strategies for construction.

Efficacy and mechanisms of Traditional Chinese Medicine prevention and treatment for respiratory viruses

Respiratory virus infection was the most common viral infection in clinical practice with the greatest impact,including the Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),posing a huge threat to the world's public health and human life safety.Commonly used antiviral drugs have obvious side effects and a narrow scope of application.Respiratory viruses are susceptible to infection,mutation,and prevalence,which also pose challenges to traditional antiviral drugs and vaccine development.Traditional Chinese Medicine(TCM)has a long history of treating infectious diseases,with many herbs and compounds.Its multi-component,multi-target and multi-path characteristics have made it have great advantages and potential in the development of new anti-respiratory virus drugs.This review summarized TCM for the prevention and treatment of common respiratory viruses,and provided new strategies for the research and development of new TCM antiviral drugs and for responding to infectious respiratory virus diseases.

A nonlocal dispersal and time delayed HIV infection model with general incidences

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be considered.In this paper,we establish an HIV infection model with nonlocal dispersal and infection age.Moreover,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and dispersal.The well-posedness,positivity,and boundedness of the solution for the model are studied.

Comparison of mechanisms and efficacies of five formulas for improving blood circulation and removing blood stasis

Objective This study aimed to compare the mechanisms and efficacies of five formulas that improve blood circulation and remove blood stasis.Methods(1)A network pharmacology method was used to determine the targets of five formulas that promote circulation and remove blood stasis.Compounds of the five formulas,namely Danshen Yin(丹参饮,DSY),Huoluo Xiaoling Dan(活络效灵丹,HLXLD),Shixiao San(失笑散,SXS),Taohong Siwu Tang(桃红四物汤,THSWT),and Xuefu Zhuyu Tang(血府逐瘀汤,XFZYT),were retrieved from the Traditonal Chinese Medicine System Pharmacology Database(TCMSP),the Shanghai Institute of Organic Chemistry of CAS,and the TCM Integrated Database.Drug target network was constructed by searching the Swiss Target Prediction database and the STITCH database.The target network of stasis was extracted from the PharmGKB database,the Online Mendelian Inheritance in Man(OMIM)database,the Genetic Association Database(GAD),and the Therapeutic Target Database(TTD).Candidate targets were determined using protein-protein interaction(PPI)network extension and topology selection.Thereafter,Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis was used to determine the differentiation of the mechanism of the five formulas.(2)Animal experiments were conducted to explore the efficacies of the five formulas in treating blood stasis.Seventy New Zealand rabbits were exposed to high-fat feeding+epinephrine injection to construct a blood stasis syndrome model.The rabbits were evenly divided into control,model,DSY,HLXLD,SXS,THSWT,and XFZYT groups.The latter five groups were orally administered the corresponding formulas[DSY:3.92 g/(kg·d),XFZYT:7.10 g/(kg·d),SXS:1.12 g/(kg·d),HLXLD:5.60 g/(kg·d),THSWT:4.48 g/(kg·d)].Serum lipid and blood rheology were analyzed,and pathology slices were observed.Results(1)A total of 269,358,288,370,and 376 candidate targets of DSY,HLXLD,SXS,THSWT,and XFZYT were obtained among which were 232 shared candidate targets.Fluid shear stress and atherosclerosis were the biological processes common to the five formulas.HLXLD,SXS,DSY,and THSWT regulated lipolysis in adipocytes,and XFZYT,HLXLD,SXS,and THSWT regulated the AGE-RAGE signaling pathway and complement and coagulation cascades.HLXLD,SXS,and XFZYT regulated the HIF-1 signaling pathway,DSY regulated the cGMP-PKG signaling pathway,HLXLD reduced platelet activation,SXS regulated the calcium signaling pathway,and XFZYT regulated the PPAR signaling pathway.(2)In the animal experiments,the values of total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL),high density lipoprotein cholesterol(HDL),TC/HDL,and TG/HDL in each group decreased,among which the ones seen in XFZYT,HLXLD,and SXS groups were statistically significant(P<0.05).XFZYT presented the best effect,followed by HLXLD and SXS.XFZYT and HLXLD decreased apolipoprotein B100(apoB100)and increased apolipoprotein A1/apoB100(P<0.05).XFZYT decreased all the values of hematocrit(HCT),plasma viscosity,whole blood viscosity(WBV);HLXLD and SXS affected HCT;and DSY and THSWT regulated WBV(P<0.05).All the five formulas decreased the values of optical density and area of plaque,among which XFZYT and HLXLD showed statistical significance(P<0.05).Conclusion Adjusting fluid shear stress and alleviating the injury of endothelial cells might be the common mechanisms by which the five formulas promote blood circulation and remove blood stasis.Different formulas also have unique targets,which may provide guidance for clinical drug selection.By regulating different indices,the five formulas can regulate blood lipid and hemorheology,improve the state of blood stasis,and decrease the degree of aortic plaque in the blood stasis model rabbits.XFZYT and HLXLD had higher efficacies than DSY,THSWT,and SXS.

Auction mechanism design of the Chinese national carbon market for carbon neutralization

The carbon market auction mechanism is an important policy tool for carbon pricing and a key mechanism that supports carbon emission neutralization,especially for China.A few systematic studies exist on China’s carbon market auction mechanism.This article focuses on the five auction mechanisms in Chinese pilot emission trading schemes(ETS),reviews the structures and bidding situation of the five-pilot auction mechanism,extracts the similarities,and analyzes their different features,such as auction mode,bidding scale,participants,pricing mode,auction frequency,and so on.This study conducts an in-depth analysis of the carbon allowance auction mechanism in the Guangdong pilot ETS of China,including its development and the evolution of the key elements,its operational effects,and related disputes.Finally,this study puts forward the trend forecast and suggestions for the Chinese allowance auction mechanism,such as the time window of launching national allowance auctions,the most likely auction mode,carbon pricing,and bidding revenue management.Carbon pricing by auction is the most powerful policy tool for addressing carbon emissions reduction and implementing the Glasgow Climate Pact.

Cross-sectional study of traumatic stress disorder in frontline nurses 6 mo after the outbreak of the COVID-19 in Wuhan

BACKGROUND Frontline nurses in Wuhan directly fighting severe acute respiratory syndrome coronavirus-2 diseases are at a high risk of infection and are extremely susceptible to psychological stress,especially due to the global coronavirus disease 2019(COVID-19)pandemic.The psychological after-effects of this public health emergency on frontline nurses will last for years.AIM To assess factors influencing post-traumatic stress disorder(PTSD)among frontline nurses in Wuhan 6 mo after the COVID-19 pandemic began.METHODS A total of 757 frontline nurses from five hospitals in Wuhan,China,participated in an online survey from July 27 to August 13,2020.This cross-sectional online study used a demographic information questionnaire,the PTSD Checklist for the Diagnostic and Statistical Manual of Mental Disorders,the Connor-Davidson Resilience Scale,and the Patient Health Questionnaire-4.The chisquare test and logistic regression were used to analyze the association of demographics,COVID-19-related variables,and PTSD.Logistic regression was also conducted to investigate which variables were associated with PTSD outcomes.RESULTS A total of 13.5%,24.3%,and 21.4%of the frontline nurses showed symptoms of PTSD,depression,and anxiety,respectively.The multivariate logistic regression analysis showed that the following factors were strongly associated with PTSD:Having a relative,friend,or colleague who died of COVID-19;experiencing stigma;or having psychological assistance needs,depressive symptoms or anxiety.Showing resilience and receiving praise after the COVID-19 outbreak were protective factors.CONCLUSION Frontline nurses still experienced PTSD(13.5%)six months after the COVID-19 outbreak began.Peer support,social support,official recognition,reward mechanisms,exercise,better sleep,and timely provision of information(such as vaccine research progress)by the government via social media,and adequate protective supplies could mitigate the level of PTSD among nurses responding to COVID-19.Stigmatization,depression,and anxiety might be associated with a greater risk of PTSD among nurses.

Analysis of the Influence of the Self-efficacy of College Students on Their Response Behaviors Toward COVID-19

Objective:This study aims to investigate the self-efficacy of college students during the Coronavirus disease 2019(COVID-19)pandemic and to conduct an empirical analysis on its influence mechanism on decision-making and coping skills to provide reference for decision support to improve the coping behavior of college students during public health emergencies.Methods:The study recruited a total of 1,346 college students in Shaanxi.Data were collected via a questionnaire and analyzed using SPSS 22.0 and AMOS 22.0.Result:The self-efficacy of the college students exerted a significantly positive impact on their coping decisions(β=0.754)and coping skills(β=0.822)during the COVID-19 pandemic.Both passed the significance test at a 99.9%confidence interval(99%CI).Conclusion:During the COVID-19 pandemic,improving the self-efficacy of college students can significantly positively influence their coping behaviors.Therefore,providing effective interventions that target the self-efficacy of college students and encouraging them to adopt positive coping behaviors is necessary.

The Evolution and Trend Analysis of Rural Planning Research Hotspots under the Background of Territorial and Spatial Planning

Under the background of the new round of land and space planning,the research on rural planning in China is undergoing positive changes.Based on the past emphasis on engineering thinking and planning technology,it has entered the field of planning strategy and planning guidance.The extended development trend shows a research trend of intensified integration with public management disciplines and government governance theories.The intervention of government regulation research will provide a solid theoretical guarantee for the rural revitalization strategy that focuses on planning and planning first.In order to study the rural planning hotspots and trends in the context of territorial and spatial planning,using CiteSpace software to map rural areas from the perspectives of the number of articles,authors,publishing organizations,keyword co-occurrence networks,keyword clustering analysis,hotspot evolution,prominent word analysis,etc.The knowledge map was planned and visualized comparative analysis was carried out.

Exploring the Development Prospects of Tibetan Medicine

Tibetan medicine is a“bright pearl in the treasure house”of traditional ethnic medicine in China.It has the benefits of a complete and time-honored theoretical development system of ethnic medicine,unique diagnosis and treatment methods with ethnic characteristics,as well as patent prescriptions that are summarized and developed for various diseases.However,obstacles such as high cost,complicated processing techniques and medication methods,as well as those in cultural exchanges are impeding the development process of Tibetan medicine.In an era where modern medical technologies and traditional Chinese medicine are advancing hand in hand,this paper proposes strategies to promote Tibetan medicine’s industrialization,policy support,social attention,and internationalization,in order to advance the use of Tibetan medicine in serving a greater number of people with its unique benefits,and thus realizing the dream of“Healthy China.”

Research on the Dissemination and Development of Traditional Chinese Medicine Dietotherapy Culture

The traditional Chinese medicine(TCM)culture has seen an unprecedented rise in popularity across the world in recent years,as China’s international stature has improved,and its cultural soft power has grown.At the same time,people are becoming more aware of all kinds of respiratory and cerebrovascular diseases,along with other health-concerning factors.Therefore,people are gradually casting their eyes on TCM dietotherapy culture,which has been studied by the Chinese people for thousands of years and has made indelible contributions to the prevention and treatment of diseases and the Chinese nation’s longevity.However,its principle of action,prevention and control efficacy,as well as standards have been questioned;thus,its development prospects are of concern to the people.On this basis,this study explores the development status,transmission channels,and development prospects of TCM dietotherapy culture.

Research Progress of College Students'Learning Burnout

Learning burnout is a common psychological problem of college students,which seriously affects college students'academic achievement and physical and mental health,wastes educational resources,and brings various hidden dangers to talent growth and social development.Starting from the definition of the concept of learning burnout,this paper introduces the dimension composition and measurement tools of college students'learning burnout,analyzes the influencing factors of college students'learning burnout,and puts forward the corresponding research prospects in view of the shortcomings of previous research.

The Relationship between Flow Experience in Leisure and Life Satisfaction in Undergraduates

Objective:To understand the current situation of undergraduates’flow experience in leisure and life satisfaction,and to explore the relationship between the two.Methods:A stratified random sampling method was used to select 781 undergraduates(377 males and 410 females)from 7 colleges and universities in Guangdong Province.They were investigated using the Flow Experience in Leisure Questionnaire(FELQ)and the Youth Life Satisfaction Scale(YLSS).Results:The total scores of FELQ and YLSS of the students in this group are(161.73±19.81)and(174.45±26.50).FELQ’s unity of knowledge and action,challenge and skill balance,concentration,grade ranking,family economic status are positively related to YLSS’life satisfaction(β=.227,.115,.098,.158,.082,P<.05);“Like to sleep during leisure”is negatively correlated with life satisfaction of YLSS(β=-.097,P<.05);FELQ’s unity of knowledge and action,concentration,grade ranking and family economic status are positively related to YLSS’s self-satisfaction(β=.286,.126,.194,.096,P<.01);“Like to sleep during leisure”is negatively correlated with YLSS’s self-satisfaction(β=-.091,P<.01);FELQ’s unity of knowledge and action,challenge and skill balance,father’s occupation,“like self-study in leisure”are positively related to YLSS’environmental satisfaction(β=.198,.131,.075,.073,P<.05);“Like to sleep during leisure”,gender and YLSS environment satisfaction negatively correlated(β=-.094,-.091,P<.01).Conclusion:Flow experience in leisure,types of leisure activities,gender,grade ranking and family factors(family economic status and father’s occupation)may be related factors for the development of college students’life satisfaction.

Nursing homes’social responsibility and competitive edge:a cross‐sectional study on elderly choices about care service and price levels in Zhejiang Province,China

Background In the context of China's aging population,meeting consumer demand is an essential way for nursing homes to fulfill social responsibilities and improve competitive advantages.However,since little is known about the elderly's service level and price choices for nursing home care,this study aims to explore the non-disabled elderly's nursing home admission intention,service level,and price choices.Methods A cross-sectional survey of 402 non-disabled respondents was conducted in three different income level cities of Zhejiang Province,in July and August 2018.Multinomial logistic regression and multiple linear regression were used to identify the determinants of admission intention,service level choice,and price choice.Results Education,residence,and number of children were significantly associated with nursing home admission intention.Compared to those with no intention,the elderly with higher income and household wealth were less likely to have conditional intentions,and those living with the family were less likely to have unconditional intentions.Compared to medium-level services,the elderly with higher monthly income(relative risk ratio[RRR]3.07,95%confidence interval[CI]:1.801 to 5.233),household wealth(RRR 5.451,95%CI:2.249 to 13.216),and age(RRR 1.528,95%CI:1.004 to 2.326)were more likely to prefer high-level services,while older adults with higher monthly income(RRR 0.516,95%CI:0.344 to 0.774),and those with pensions(RRR 0.267,95%CI:0.076 to 0.931)were less likely to prefer low-level services.The elderly's price preference increased by 398 CNY as monthly income increased by 1000 CNY,and by 270 CNY as the housing number increased by one.Having pensions increased price preference(468 CNY),whereas having health insurance decreased price preference(–690 CNY).Conclusion The elderly's intention of nursing home admission was primarily affected by sociodemographic factors,while price and service level choices were primarily affected by financial factors.Nursing homes should use the market segmentation method to provide precision nursing home care for different groups of non-disabled elderly.

Efficacy of Baishao Luoshi decoction(白芍络石方)on synaptic plasticity in rats with post stroke spasticity

OBJECTIVE:To evaluate the efficacy of Baishao Luoshi decoction(白芍络石方,BD)on synaptic plasticity in rats with post stroke spasticity(PSS),and to study the mechanism behind the action.METHODS:The PSS model of rat was established by middle cerebral artery occlusion(MCAO).The neurological deficit symptoms were evaluated by modified neurological deficit score(mN SS).Muscle tension were evaluated by Modified Ashworth score(MAS).Transmission electron microscopy(TEM)was used to observe the synaptic ultrastructure.The expression of synaptic plasticity-related protein brain derived neurotrophic factor(BDNF),growth associated protein-43(GAP43),synaptophysin(p38)and microtubule-associated protein 2(MAP2)in the brain tissue around the infarct were detected by Western blotting.RESULTS:We found that mNSS were significantly improved and limb spasticity was ameliorated treated by BD.The thickness of postsynaptic density and the synaptic curvature increased significantly.The expression of synaptic plasticity-related protein BDNF,GAP43,p38,MAP2 in the brain tissue around the infarct were raised remarkably after treated by BD.CONCLUSIONS:Alleviating PSS by BD may be related to rescuing the synaptic plasticity,which provides a probable new therapeutic method for PSS.

Clinical and Psychometric Validation of the Quality of Life Assessment System for Advanced Gastric Cancer Based on Traditional Chinese Medicine

Objective： To establish questionnaire scaling and reliability and examine the clinical and psychometric validity of the quality of life assessment based on Traditional Chinese Medicine for advanced gastric cancer（QLASTCM-Ga）. Methods： The QLASTCM-Ga was developed based on programmed decision procedures with multiple nominal and focus group discussions, in-depth interview, pretesting and quantitative statistical procedures. The questionnaire was administered to 240 patients diagnosed with advanced gastric cancer before and after treatment. Structured group methods were employed to establish a general and a specific module respectively. The psychometric properties of the scale were evaluated with respect to validity, reliability and responsiveness. Results： The three identified scales of the QLASTCM-Ga and the total score demonstrated good psychometric properties. Test-retest reliability of the total scale and all domains ranged from 0.90 to 0.94, and internal consistency ranged from 0.86 to 0.93. Correlation and factor analysis demonstrated good construct validity. Significant difference in the subscales and the total score were found among groups differing in traditional Chinese medicine syndrome, supporting the clinical sensitivity of the QLASTCM-Ga. Statistically significant changes were found for each scale and the total score. Responsiveness was also good. Conclusions： The QLASTCM-Ga demonstrates good psychometric and clinical validity to assess quality of life in patients with advanced gastric cancer undergoing traditional Chinese medicine therapy. This study is an important first step for future research in this area.

Marital Status as a Moderator:Exploring the Relationship between Social Engagement and Depressive Symptoms in China’s Older Adult Population

Objective This study aims to explore the complex relationship between social engagement and depressive symptoms among older adults in China,focusing particularly on the moderating role of marital status.Methods This study used data from the latest Chinese Longitudinal Healthy Longevity Survey(CLHLS).The analysis used the latent class analysis to delineate personality clusters and hierarchical linear regression,supplemented by the PROCESS macro,to investigate the effects of social engagement and marital status on depressive symptoms.Results The analysis encompassed 7,789 respondents(mean age:82.53[s=11.20]years),with 54%female.The personality analysis categorized participants into four clusters,with the majority(77.60%)classified as Confident Idealists,who exhibited the lowest levels of depressive symptoms.Hierarchical linear regression analysis yielded several significant findings:Higher levels of social engagement were significantly associated with fewer depressive symptoms(t=-7.932,P<0.001,B=-0.463).Marital status was a significant factor;married individuals reported fewer depressive symptoms compared to their unmarried counterparts(t=-6.368,P<0.001,B=-0.750).There was a significant moderating effect of marital status on the relationship between social engagement and depressive symptoms(t=-2.092,P=0.037,B=-0.217).Conclusion This study demonstrates that,among Chinese older adults,both social engagement and marital status significantly influence depressive symptoms.Higher social engagement,particularly in other activities like doing household chores,gardening,reading newspapers or books,and playing cards or Mahjong,is associated with fewer depressive symptoms,especially among married individuals.

Optimal incentive mechanism for dual referral based on the analytic hierarchy process

Objective:The optimal incentive mechanism for dual referral is discussed to provide a decision-making foundation for the implementation of a dual referral incentive mechanism.Methods:We established a multi-hierarchy evaluation model for a dual referral incentive mechanism by analyzing the main schemes and measures used to stimulate dual referral.The weight values of every scheme or measure were determined and consistency tests were carried out using expert judgement methods and an analytic hierarchy process.Results:The weight values of patients,community physicians,and hospital physicians as the incentive objects were 0.2583,0.1047,and 0.6370,respectively,and the weight values of medical insurance-based reward and punishment,community medical center construction,referral plat-form,and publicity and communication as incentive schemes were 0.4950,0.3103,0.1164,and 0.0783,respectively.Conclusion:The main incentive object in the implementation of a dual referral is the hospital physician,followed by the patient.The most workable incentive scheme is“medical insurance-based reward and punishment,”followed by“community medical center construction.”