An efficient synthesis of 2,6-pyridine dimethyl formate happened under the microwave irradiation is proposed. It is noteworthy that some factors influence the product yield such as time, temperature, ratio of reactant...An efficient synthesis of 2,6-pyridine dimethyl formate happened under the microwave irradiation is proposed. It is noteworthy that some factors influence the product yield such as time, temperature, ratio of reactants, and acidity which were discussed. The optimized quantity of 2,6-pyridine dimethyl acid is 10 mmol and methanol is 25 mmol. The yield is up to 95%-96% when using 2 mL 30% sulfuric acid. All products have been characterized by IR and 1H NMR.展开更多
文摘An efficient synthesis of 2,6-pyridine dimethyl formate happened under the microwave irradiation is proposed. It is noteworthy that some factors influence the product yield such as time, temperature, ratio of reactants, and acidity which were discussed. The optimized quantity of 2,6-pyridine dimethyl acid is 10 mmol and methanol is 25 mmol. The yield is up to 95%-96% when using 2 mL 30% sulfuric acid. All products have been characterized by IR and 1H NMR.
