Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis.In this study, we prepared mu...Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis.In this study, we prepared multifunctional microspheres loading ^(131)I-labeled hollow copper sulfide nanoparticles and paclitaxel( ^(131)I-HCu SNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats.18 F-fluordeoxyglucose(18 F-FDG) positron emission tomography/computed tomography(PET/CT) imaging detected that the expansion of the tumor volume was delayed(Po0.05) following intra-tumoral(i.t.) injection with ^(131)I-HCu SNPs-MS-PTX plus near-infrared(NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography(SPECT)/photoacoustic imaging mediated by ^(131)I-HCu SNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that ^(131)I-HCu SNPs-MS-PTX offered combined photothermal, chemo-and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, ^(131)I-HCu SNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.展开更多
Objective：To find an appropriate feature representation in the biclustering of symptom-herb relationship in Chinese medicine（CM）.Methods： Four different representation schemes were tested in identifying the comple...Objective：To find an appropriate feature representation in the biclustering of symptom-herb relationship in Chinese medicine（CM）.Methods： Four different representation schemes were tested in identifying the complex relationship between symptoms and herbs using a biclustering algorithm on an insomnia data set.These representation schemes were effective count,binary value,relative success ratio,or modified relative success ratio.The comparison of the schemes was made on the number and size of biclusters with respect to different threshold values.Results and Conclusions：The modified relative success ratio scheme was the most appropriate feature representation among the four tested.Some of the biclusters selected from this representation scheme were known to follow the therapeutic principles of CM,while others may offer clues for further clinical investigations.展开更多
Speaker variability is an important source of speech variations which makes continuous speech recognition a difficult task.Adapting automatic speech recognition(ASR) models to the speaker variations is a well-known st...Speaker variability is an important source of speech variations which makes continuous speech recognition a difficult task.Adapting automatic speech recognition(ASR) models to the speaker variations is a well-known strategy to cope with the challenge.Almost all such techniques focus on developing adaptation solutions within the acoustic models of the ASR systems.Although variations of the acoustic features constitute an important portion of the inter-speaker variations,they do not cover variations at the phonetic level.Phonetic variations are known to form an important part of variations which are influenced by both micro-segmental and suprasegmental factors.Inter-speaker phonetic variations are influenced by the structure and anatomy of a speaker's articulatory system and also his/her speaking style which is driven by many speaker background characteristics such as accent,gender,age,socioeconomic and educational class.The effect of inter-speaker variations in the feature space may cause explicit phone recognition errors.These errors can be compensated later by having appropriate pronunciation variants for the lexicon entries which consider likely phone misclassifications besides pronunciation.In this paper,we introduce speaker adaptive dynamic pronunciation models,which generate different lexicons for various speaker clusters and different ranges of speech rate.The models are hybrids of speaker adapted contextual rules and dynamic generalized decision trees,which take into account word phonological structures,rate of speech,unigram probabilities and stress to generate pronunciation variants of words.Employing the set of speaker adapted dynamic lexicons in a Farsi(Persian) continuous speech recognition task results in word error rate reductions of as much as 10.1% in a speaker-dependent scenario and 7.4% in a speaker-independent scenario.展开更多
基金partially supported by National Natural Science Foundation of China (Nos. 81771861, 81471708, 81673018, 81530053, 81471685)the award of the "National Youth Thousand Talents Plan" of China, the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No. 2012-05)+2 种基金Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support (No. 20172010)2018 Shanghai Scientific and Technological Innovation Program(No. 18410711200)the Ph.D. Innovation Fund of Shanghai Jiao Tong University, School of Medicine (BXJ201821)
文摘Compared to conventional cancer treatment, combination therapy based on well-designed nanoscale platforms may offer an opportunity to eliminate tumors and reduce recurrence and metastasis.In this study, we prepared multifunctional microspheres loading ^(131)I-labeled hollow copper sulfide nanoparticles and paclitaxel( ^(131)I-HCu SNPs-MS-PTX) for imaging and therapeutics of W256/B breast tumors in rats.18 F-fluordeoxyglucose(18 F-FDG) positron emission tomography/computed tomography(PET/CT) imaging detected that the expansion of the tumor volume was delayed(Po0.05) following intra-tumoral(i.t.) injection with ^(131)I-HCu SNPs-MS-PTX plus near-infrared(NIR) irradiation. The immunohistochemical analysis further confirmed the anti-tumor effect. The single photon emission computed tomography(SPECT)/photoacoustic imaging mediated by ^(131)I-HCu SNPs-MS-PTX demonstrated that microspheres were mainly distributed in the tumors with a relatively low distribution in other organs. Our results revealed that ^(131)I-HCu SNPs-MS-PTX offered combined photothermal, chemo-and radio-therapies, eliminating tumors at a relatively low dose, as well as allowing SPECT/CT and photoacoustic imaging monitoring of distribution of the injected agents non-invasively. The copper sulfide-loaded microspheres, ^(131)I-HCu SNPs-MS-PTX, can serve as a versatile theranostic agent in an orthotopic breast cancer model.
文摘Objective：To find an appropriate feature representation in the biclustering of symptom-herb relationship in Chinese medicine（CM）.Methods： Four different representation schemes were tested in identifying the complex relationship between symptoms and herbs using a biclustering algorithm on an insomnia data set.These representation schemes were effective count,binary value,relative success ratio,or modified relative success ratio.The comparison of the schemes was made on the number and size of biclusters with respect to different threshold values.Results and Conclusions：The modified relative success ratio scheme was the most appropriate feature representation among the four tested.Some of the biclusters selected from this representation scheme were known to follow the therapeutic principles of CM,while others may offer clues for further clinical investigations.
文摘Speaker variability is an important source of speech variations which makes continuous speech recognition a difficult task.Adapting automatic speech recognition(ASR) models to the speaker variations is a well-known strategy to cope with the challenge.Almost all such techniques focus on developing adaptation solutions within the acoustic models of the ASR systems.Although variations of the acoustic features constitute an important portion of the inter-speaker variations,they do not cover variations at the phonetic level.Phonetic variations are known to form an important part of variations which are influenced by both micro-segmental and suprasegmental factors.Inter-speaker phonetic variations are influenced by the structure and anatomy of a speaker's articulatory system and also his/her speaking style which is driven by many speaker background characteristics such as accent,gender,age,socioeconomic and educational class.The effect of inter-speaker variations in the feature space may cause explicit phone recognition errors.These errors can be compensated later by having appropriate pronunciation variants for the lexicon entries which consider likely phone misclassifications besides pronunciation.In this paper,we introduce speaker adaptive dynamic pronunciation models,which generate different lexicons for various speaker clusters and different ranges of speech rate.The models are hybrids of speaker adapted contextual rules and dynamic generalized decision trees,which take into account word phonological structures,rate of speech,unigram probabilities and stress to generate pronunciation variants of words.Employing the set of speaker adapted dynamic lexicons in a Farsi(Persian) continuous speech recognition task results in word error rate reductions of as much as 10.1% in a speaker-dependent scenario and 7.4% in a speaker-independent scenario.
