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Performance optimization of a SERF atomic magnetometer based on flat-top light beam
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作者 袁子琪 唐钧剑 +1 位作者 林树东 翟跃阳 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期330-336,共7页
We explore the impact of pumping beams with different transverse intensity profiles on the performance of the spinexchange relaxation-free(SERF) atomic magnetometers(AMs). We conduct experiments comparing the traditio... We explore the impact of pumping beams with different transverse intensity profiles on the performance of the spinexchange relaxation-free(SERF) atomic magnetometers(AMs). We conduct experiments comparing the traditional Gaussian optically-pumped AM with that utilizing the flat-top optically-pumped(FTOP) method. Our findings reveal that the FTOP-based approach outperforms the conventional method, exhibiting a larger response, a narrower magnetic resonance linewidth, and a superior low-frequency noise performance. Specifically, the use of FTOP method leads to a 16% enhancement in average sensitivity within 1 Hz–30 Hz frequency range. Our research emphasizes the significance of achieving transverse polarization uniformity in AMs, providing insights for future optimization efforts and sensitivity improvements in miniaturized magnetometers. 展开更多
关键词 atomic magnetometer(AM) spin-exchange relaxation-free(SERF) flat-top light beam performance optimization
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Fast Two-dimensional Positioning Method of Crab Pulsar Based on Multiple Optimization Algorithms
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作者 Jianfeng Chen Jin Liu +1 位作者 Xin Ma Xiaolin Ning 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第10期92-103,共12页
In the two-dimensional positioning method of pulsars, the grid method is used to provide non-sensitive direction and positional estimates. However, the grid method has a high computational load and low accuracy due to... In the two-dimensional positioning method of pulsars, the grid method is used to provide non-sensitive direction and positional estimates. However, the grid method has a high computational load and low accuracy due to the interval of the grid. To improve estimation accuracy and reduce the computational load, we propose a fast twodimensional positioning method for the crab pulsar based on multiple optimization algorithms(FTPCO). The FTPCO uses the Levenberg–Marquardt(LM) algorithm, three-point orientation(TPO) method, particle swarm optimization(PSO) and Newton–Raphson-based optimizer(NRBO) to substitute the grid method. First, to avoid the influence of the non-sensitive direction on positioning, we take an orbital error and the distortion of the pulsar profile as optimization objectives and combine the grid method with the LM algorithm or PSO to search for the non-sensitive direction. Then, on the sensitive plane perpendicular to the non-sensitive direction, the TPO method is proposed to fast search the sensitive direction and sub-sensitive direction. Finally, the NRBO is employed on the sensitive and sub-sensitive directions to achieve two-dimensional positioning of the Crab pulsar. The simulation results show that the computational load of the FTPCO is reduced by 89.4% and the positioning accuracy of the FTPCO is improved by approximately 38% compared with the grid method. The FTPCO has the advantage of high real-time accuracy and does not fall into the local optimum. 展开更多
关键词 (stars:)pulsars:individual(Crab pulsar) space vehicles methods:data analysis ASTROMETRY
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Method of improving pedestrian navigation performance based on chest card
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作者 CHENG Hao GAO Shuang +2 位作者 CAI Xiaowen WANG Yuxuan WANG Jie 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期987-998,共12页
With the development of positioning technology,loca-tion services are constantly in demand by people.As a primary location service pedestrian navigation has two main approaches based on radio and inertial navigation.T... With the development of positioning technology,loca-tion services are constantly in demand by people.As a primary location service pedestrian navigation has two main approaches based on radio and inertial navigation.The pedestrian naviga-tion based on radio is subject to environmental occlusion lead-ing to the degradation of positioning accuracy.The pedestrian navigation based on micro-electro-mechanical system inertial measurement unit(MIMU)is less susceptible to environmental interference,but its errors dissipate over time.In this paper,a chest card pedestrian navigation improvement method based on complementary correction is proposed in order to suppress the error divergence of inertial navigation methods.To suppress atti-tude errors,optimal feedback coefficients are established by pedestrian motion characteristics.To extend navigation time and improve positioning accuracy,the step length in subsequent movements is compensated by the first step length.The experi-mental results show that the positioning accuracy of the pro-posed method is improved by more than 47%and 44%com-pared with the pure inertia-based method combined with step compensation and the traditional complementary filtering com-bined method with step compensation.The proposed method can effectively suppress the error dispersion and improve the positioning accuracy. 展开更多
关键词 pedestrian navigation micro-electro-mechanical sy-stem(MEMS) inertial navigation complementary filtering
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Split Lohmann computer holography: fast generation of 3D hologram in single-step diffraction calculation
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作者 Chenliang Chang Xian Ding +5 位作者 Di Wang Zhizhou Ren Bo Dai Qi Wang Songlin Zhuang Dawei Zhang 《Advanced Photonics Nexus》 2024年第3期1-13,共13页
Holographic display stands as a prominent approach for achieving lifelike three-dimensional(3D)reproductions with continuous depth sensation.However,the generation of a computer-generated hologram(CGH)always relies on... Holographic display stands as a prominent approach for achieving lifelike three-dimensional(3D)reproductions with continuous depth sensation.However,the generation of a computer-generated hologram(CGH)always relies on the repetitive computation of diffraction propagation from point-cloud or multiple depthsliced planar images,which inevitably leads to an increase in computational complexity,making real-time CGH generation impractical.Here,we report a new CGH generation algorithm capable of rapidly synthesizing a 3D hologram in only one-step backward propagation calculation in a novel split Lohmann lens-based diffraction model.By introducing an extra predesigned virtual digital phase modulation of multifocal split Lohmann lens in such a diffraction model,the generated CGH appears to reconstruct 3D scenes with accurate accommodation abilities across the display contents.Compared with the conventional layer-based method,the computation speed of the proposed method is independent of the quantized layer numbers,and therefore can achieve real-time computation speed with a very dense of depth sampling.Both simulation and experimental results validate the proposed method. 展开更多
关键词 computer holography holographic display diffraction calculation.
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New rapid transfer alignment method for SINS of airborne weapon systems 被引量:9
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作者 Yu Chen Yan Zhao 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2014年第2期281-287,共7页
Transfer alignment is an effective alignment method for the strapdown inertial navigation system (SINS) of airborne weapon systems. The traditional transfer alignment methods for large misalignment angles alignment ... Transfer alignment is an effective alignment method for the strapdown inertial navigation system (SINS) of airborne weapon systems. The traditional transfer alignment methods for large misalignment angles alignment use nonlinear transfer align- ment models and incorporate nonlinear filtering. A rapid transfer alignment method with linear models and linear filtering for ar- bitrary misalignment angles is presented. Through the attitude quaternion decomposition, the purpose of transfer alignment is converted to estimate a constant quaternion. Employing special manipulations on measurement equation, velocity and attitude linear measurement equations are derived. Then the linear trans- fer alignment model for arbitrary misalignment angles is built. An adaptive Kalman filter is developed to handle modeling errors of the measurement noise statistics. Simulation results show feasibili- ty and effectiveness of the proposed method, which provides an alternative rapid transfer alignment method for airborne weapons. 展开更多
关键词 strapdown inertial navigation system (SINS) transferalignment Kalman filter quaternion.
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Fast fine acquisition algorithm of GPS receiver aided by INS information 被引量:6
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作者 Lufeng Zhu Chunxi Zhang Zhiqiang Ma 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第2期300-305,共6页
Acquisition time of global position system (GPS) receiver, which is the main factor contributes to time to first fix (TTFF), can be shortened by estimating the Doppler frequency shift through external inertial nav... Acquisition time of global position system (GPS) receiver, which is the main factor contributes to time to first fix (TTFF), can be shortened by estimating the Doppler frequency shift through external inertial navigation system (INS) information and almanac data and reducing the searching area. The traditional fast acquisition is analyzed, the fast acquisition of the GPS receiver aided is presented by INS information, and the signal is fine captured by spectrum zooming. Then the algorithm is simulated by sampled GPS intermediate frequency (IF) signal and the result verifies that this acquisition can dramatically improve the capability of GPS receiver and reduce its acquisition time. 展开更多
关键词 inertial navigation system (INS) aid spectrum zooming acquisition time global position system (GPS) receiver.
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Dynamic grey model of verification cycle and lifecycle of measuring instrument and its application 被引量:4
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作者 苏海涛 杨世元 +1 位作者 董华 沈毛虎 《Journal of Central South University》 SCIE EI CAS 2005年第S2期86-89,共4页
Two dynamic grey models DGM (1, 1) for the verification cycle and the lifecycle of measuring instrument based on time sequence and frequency sequence were set up, according to the statistical feature of examination da... Two dynamic grey models DGM (1, 1) for the verification cycle and the lifecycle of measuring instrument based on time sequence and frequency sequence were set up, according to the statistical feature of examination data and weighting method. By a specific case, i.e. vernier caliper, it is proved that the fit precision and forecast precision of the models are much higher, the cycles are obviously different under different working conditions, and the forecast result of the frequency sequence model is better than that of the time sequence model. Combining dynamic grey model and auto-manufacturing case the controlling and information subsystems of verification cycle and the lifecycle based on information integration, multi-sensor controlling and management controlling were given. The models can be used in production process to help enterprise reduce error, cost and flaw. 展开更多
关键词 measuring equipment verification cycle LIFECYCLE dynamic grey model qualification rate information system
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Monitoring elevation change of glaciers on Geladandong Mountain using Tan DEM-X SAR interferometry 被引量:6
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作者 LIU Guang FAN Jing-hui +2 位作者 ZHAO Feng MAO Ke-biao DOU Chang-yong 《Journal of Mountain Science》 SCIE CSCD 2017年第5期859-869,共11页
Glaciers play an important role in the climate system. The elevation change of a glacier is an important parameter in studies of glacier dynamics. Only a few ground-based measurements of high mountain glaciers are ava... Glaciers play an important role in the climate system. The elevation change of a glacier is an important parameter in studies of glacier dynamics. Only a few ground-based measurements of high mountain glaciers are available due to their remoteness, high elevation, and complex topography. The acquisition from the German Tan DEM-X(Terra SAR-X add-on for Digital Elevation Measurement) SAR imaging configuration provides a reliable data sources for studying the elevation change of glaciers. In this study, the bistatic Tan DEM-X data that cover the Geladandong Mountain on the Tibetan Plateau were processed with SAR interferometry technique and the elevation changes of the mountain's glaciers during 2000–2014 were obtained. The results indicated that although distinct positive and negative elevation changes were found for different glacier tongues, the mean elevation change was about-0.14±0.26 m a-1. Geoscience Laser Altimeter System(GLAS) data were obtained for comparison and verification. The investigation using GLAS data demonstrated the efficacy of the proposed method in determining glacier elevation change. Thus, the presented approach is appropriate for monitoring glacier elevation change and it constitutes a valuable tool for studies of glacier dynamics. 展开更多
关键词 Elevation change Glacier Syntheticaperture radar interferometry Tan DEM-X Geladandongmountain Tibetan Plateau
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Iterative Learning Disturbance Observer Based Attitude Stabilization of Flexible Spacecraft Subject to Complex Disturbances and Measurement Noises 被引量:4
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作者 Tongfu He Zhong Wu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第9期1576-1587,共12页
To realize high-precision attitude stabilization of a flexible spacecraft in the presence of complex disturbances and measurement noises,an iterative learning disturbance observer(ILDO)is presented in this paper.First... To realize high-precision attitude stabilization of a flexible spacecraft in the presence of complex disturbances and measurement noises,an iterative learning disturbance observer(ILDO)is presented in this paper.Firstly,a dynamic model of disturbance is built by augmenting the integral of the lumped disturbance as a state.Based on it,ILDO is designed by introducing iterative learning structures.Then,comparative analyses of ILDO and traditional disturbance observers are carried out in frequency domain.It demonstrates that ILDO combines the advantages of high accuracy in disturbance estimation and favorable robustness to measurement noise.After that,an ILDO based composite controller is designed to stabilize the spacecraft attitude.Finally,the effectiveness of the proposed control scheme is verified by simulations. 展开更多
关键词 Disturbance observer iterative learning measure-ment noise spacecraft attitude control
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Movable electrowetting optofluidic lens for optical axial scanning in microscopy 被引量:9
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作者 Lei Li Liang Xiao +1 位作者 Jinhui Wang Qionghua Wang 《Opto-Electronic Advances》 2019年第2期10-14,共5页
Optical axial scanning is essential process to obtain 3D information of biological specimens. To realize optical axial scanning without moving, the tunable lens is a solution. However, the conventional tunable lenses ... Optical axial scanning is essential process to obtain 3D information of biological specimens. To realize optical axial scanning without moving, the tunable lens is a solution. However, the conventional tunable lenses usually induce non-uniform magnification and resolution issues. In this paper, we report a movable electrowetting optofluidic lens. Unlike the conventional tunable lens, our proposed optofluidic lens has two liquid-liquid (L-L) interfaces, which can move in the cell by an external voltage. The object distance and image distance are adjusted by shifting the L-L interface position. Therefore, the proposed lens can realize optical axial scanning with uniform magnification and resolution in microscopy. To prove the concept, we fabricate an optofluidic lens and use it in optical axial scanning. The scanning distance is more than 1 mm with uniform magnification and good imaging quality. Widespread application of such a new adaptive zoom lens is foreseeable. 展开更多
关键词 optofluidic LENS LIQUID LENS ZOOM system
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Performance Evaluation of IEEE 1394b Serial Bus with Deterministic and Stochastic Petri Nets 被引量:4
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作者 王明 张春熹 伊小素 《China Communications》 SCIE CSCD 2013年第2期121-133,共13页
IEEE 1394b is a high-speed data bus that is widely used in local area networks and consumer electronics. To best utilize this data bus, we need to fully understand its per- formance. To evaluate its performance for bo... IEEE 1394b is a high-speed data bus that is widely used in local area networks and consumer electronics. To best utilize this data bus, we need to fully understand its per- formance. To evaluate its performance for both isochronous and asynchronous data transfers, we model the IEEE 1394b bus using Deterministic and Stochastic Pelri Nets (DSPNs), and conduct simulations using TimeNET 4.0. Using the DSPNs model, we simulate both the average waiting times of isochronous and asynchronous packets. From the simulation results, we determine the factors that influence performance, such as throughput, size of packets, arrival rate of packets, number of isochronous channels, and bus configuration. 展开更多
关键词 performance evaluation IEEE1394B isochronous data transfer asynchro-nous data transfer
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Robust Consensus of Multi-Agent Systems with Uncertain Exogenous Disturbances 被引量:3
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作者 杨洪勇 郭雷 韩潮 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第12期1161-1166,共6页
The objective of this paper is to investigate the consensus of the multi-agent systems w/th nonlinear coupling function and external disturbances. The disturbance includes two parts, one part is supposed to be generat... The objective of this paper is to investigate the consensus of the multi-agent systems w/th nonlinear coupling function and external disturbances. The disturbance includes two parts, one part is supposed to be generated by an exogenous system, which is not required to be neutrally stable as in the output regulation theory, the other part is the modeling uncertainty in the exogenous disturbance system. A novel composite disturbance observer based control (DOBC) and H∞ control scheme is presented so that the disturbance with the exogenous system can be estimated and compensated and the consensus of the multi-agent systems with fixed and switching graph can be reached by using Hoo control law. Simulations demonstrate the advantages of the proposed DOBC and H∞ control scheme. 展开更多
关键词 robust controller multi-agent systems CONSENSUS uncertain disturbance
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Nb_(2)CT_(x) MXene: High capacity and ultra-long cycle capability for lithium-ion battery by regulation of functional groups 被引量:4
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作者 Jiabao Zhao Jing Wen +6 位作者 Junpeng Xiao Xinzhi Ma Jiahui Gao Lina Bai Hong Gao Xitian Zhang Zhiguo Zhang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第2期387-395,I0013,共10页
MXenes are well known for their potential application in supercapacitors due to their high-rate intercalation pseudocapacitance and long cyclability.However,the reported low capacity of pristine MXenes hinders their p... MXenes are well known for their potential application in supercapacitors due to their high-rate intercalation pseudocapacitance and long cyclability.However,the reported low capacity of pristine MXenes hinders their practical application in lithium-ion batteries.In this work,a robust strategy is developed to control the functional groups of Nb_2 CT_x MXene.The capacity of pristine Nb_2 CT_x MXene can be significantly increased by Li~+ intercalation and surface modification.The specific capacity of the treated Nb_2 CT_x is up to 448 mAh g^(-1) at 0.05 A g^(-1),and at a large current density of 2 A g^(-1) remains a high reversible capacity retention rate of 75% after an ultra-long cycle of 2000 cycles.These values exceed most of the reported pristine MXenes(including the most studied Ti_3 C_2 T_x) and carbon-based materials.It demonstrates that this strategy has great help to improve the electrochemical performance of pristine MXene,and the results enhance the promise of MXenes in the application of lithium-ion batteries. 展开更多
关键词 MXene Nb_(2)CT_(x) Functional groups Lithium-ion batteries
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Flexible control of semiconductor laser with frequency tunable modulation transfer spectroscopy 被引量:2
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作者 Ning Ru Yu Wang +3 位作者 Hui-Juan Ma Dong Hu Li Zhang Shang-Chun Fan 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第7期321-324,共4页
We introduce a new method of simultaneously implementing frequency stabilization and frequency shift for semiconductor lasers. We name this method the frequency tunable modulation transfer spectroscopy (FTMTS). To r... We introduce a new method of simultaneously implementing frequency stabilization and frequency shift for semiconductor lasers. We name this method the frequency tunable modulation transfer spectroscopy (FTMTS). To realize a stable output of 780 nm semiconductor laser, an FTMTS optical heterodyne frequency stabilization system is constructed. Before entering into the frequency stabilization system, the probe laser passes through an acousto-optical modulator (AOM) twice in advance to achieve tunable frequency while keeping the light path stable. According to the experimental results, the frequency changes from 120 MHz to 190 MHz after the double-pass AOM, and the intensity of laser entering into the system is greatly changed, but there is almost no change in the error signal of the FTMTS spectrum. Using this signal to lock the laser frequency, we can ensure that the frequency of the laser changes with the amount of AOM shift. Therefore, the magneto-optical trap (MOT)-molasses process can be implemented smoothly. 展开更多
关键词 semiconductor laser frequency stabilization frequency shift frequency tunable modulation trans-fer spectroscopy
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Combined effect of light intensity and temperature on the magnetic resonance linewidth in alkali vapor cell with buffer gas 被引量:1
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作者 高阳 董海峰 +2 位作者 王翔 王笑菲 尹凌霄 《Chinese Physics B》 SCIE EI CAS CSCD 2017年第6期417-421,共5页
One of the peculiar phenomenons in non-zero magnetic resonance magnetometer is that, with the increase of the temperature, the magnetic resonance linewidth is narrowed at first instead of broadened due to the increasi... One of the peculiar phenomenons in non-zero magnetic resonance magnetometer is that, with the increase of the temperature, the magnetic resonance linewidth is narrowed at first instead of broadened due to the increasing collision rate. The magnetometer usually operates at the narrowest linewidth temperature to obtain the best sensitivity. Here, we explain this phenomenon quantitatively considering the nonlinear of the optical pumping in the cell and did experiments to verify this explanation. The magnetic resonance linewidth is measured using one amplitude-modulated pump laser and one continuous probe laser. The field is along the direction orthogonal to the plane of pump and probe beams. We change the temperature from 53℃ to 93℃ and the pumping light from 0.1 mW to 2 mW. The experimental results agree well with the theoretical calculations. 展开更多
关键词 atomic magnetometer magnetic resonance LINEWIDTH TEMPERATURE
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Six-DOF trajectory optimization for reusable launch vehicles via Gauss pseudospectral method 被引量:4
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作者 Zhen Wang Zhong Wu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第2期434-441,共8页
To be close to the practical flight process and increase the precision of optimal trajectory, a six-degree-offreedom(6-DOF) trajectory is optimized for the reusable launch vehicle(RLV) using the Gauss pseudospectr... To be close to the practical flight process and increase the precision of optimal trajectory, a six-degree-offreedom(6-DOF) trajectory is optimized for the reusable launch vehicle(RLV) using the Gauss pseudospectral method(GPM). Different from the traditional trajectory optimization problem which generally considers the RLV as a point mass, the coupling between translational dynamics and rotational dynamics is taken into account. An optimization problem is formulated to minimize a performance index subject to 6-DOF equations of motion, including translational and rotational dynamics. A two-step optimal strategy is then introduced to reduce the large calculations caused by multiple variables and convergence confinement in 6-DOF trajectory optimization. The simulation results demonstrate that the 6-DOF trajectory optimal strategy for RLV is feasible. 展开更多
关键词 reusable launch vehicle(RLV) trajectory optimization Gauss pseudospectral method(GPM)
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Electron beam modeling and analyses of the electric field distribution and space charge effect 被引量:1
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作者 Yueling Jiang Quanlin Dong 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第5期288-293,共6页
In electron beam technology, one of the critical focuses of research and development efforts is on improving the measurement of electron beam parameters. The parameters are closely related to the generation, emission,... In electron beam technology, one of the critical focuses of research and development efforts is on improving the measurement of electron beam parameters. The parameters are closely related to the generation, emission, operation environment, and role of the electron beam and the corresponding medium. In this study, a field calculation method is proposed, and the electric field intensity distribution on the electron beam’s cross-section is analyzed. The characteristics of beam diffusion caused by the space charge effect are investigated in simulation, and the obtained data are compared with the experiment. The simulation demonstrated that the cross-sectional electric field distribution is primarily affected by the electron beam current, current density distribution, and electron beam propagation speed. 展开更多
关键词 electron beam electric field distribution space charge effect
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A moment-based criterion for determining the number of components in a normal mixture model 被引量:1
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作者 Yimin Zhou Liyan Han +1 位作者 Dan Wang Libo Yin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第4期801-809,共9页
Determining the number of components is a crucial issue in a mixture model. A moment-based criterion is considered to estimate the number of components arising from a normal mixture model. This criterion is derived fr... Determining the number of components is a crucial issue in a mixture model. A moment-based criterion is considered to estimate the number of components arising from a normal mixture model. This criterion is derived from an omnibus statistic involving the skewness and kurtosis of each component. The proposed criterion additionally provides a measurement for the model fit in an absolute sense. The performances of our criterion are satisfactory compared with other classical criteria through Monte-Carlo experiments. 展开更多
关键词 information criteria Gaussian mixture moment based number of components
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Compact pulsed thulium‐doped fiber laser for topographical patterning of hydrogels 被引量:2
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作者 Elizabeth Lee Biao Sun +5 位作者 Jiaqi Luo Satnam Singh Deepak Choudhury Derrick Yong Xia Yu Qijie Wang 《Opto-Electronic Advances》 2020年第6期9-17,I0001,共10页
We report the generation of high energy 2μm picosecond pulses from a thulium-doped fiber master oscillator power amplifier system.The all-fiber configuration was realized by a flexible large-mode area photonic crysta... We report the generation of high energy 2μm picosecond pulses from a thulium-doped fiber master oscillator power amplifier system.The all-fiber configuration was realized by a flexible large-mode area photonic crystal fiber(LMA-PCF).The amplifier output is a linearly-polarized 1.5 ns,100 kHz pulse train with a pulse energy of up to 250μJ.Pulse compression was achieved with(2+2)-pass chirped volume Bragg grating(CVBG)to obtain a 2.8 ps pulse width with a total pulse energy of 46μJ.The overall system compactness was enabled by the all-fiber amplifier design and the multi-pass CVBG-based compressor.The laser output was then used to demonstrate high-speed direct-writing capability on a temperature-sensitive biomaterial to change its topography(i.e.fabricate microchannels,foams and pores).The topographical modifications of biomaterials are known to influence cell behavior and fate which is potentially useful in many cell and tissue engineering applications. 展开更多
关键词 Tm-doped fiber lasers chirped pulse amplification photonic crystal fiber
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Smart palm-size optofluidic hematology analyzer for automated imaging-based leukocyte concentration detection 被引量:2
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作者 Deer Su Xiangyu Li +4 位作者 Weida Gao Qiuhua Wei Haoyu Li Changliang Guo Weisong Zhao 《Opto-Electronic Science》 2023年第12期1-8,共8页
A critical function of flow cytometry is to count the concentration of blood cells,which helps in the diagnosis of certain diseases.However,the bulky nature of commercial flow cytometers makes such tests only availabl... A critical function of flow cytometry is to count the concentration of blood cells,which helps in the diagnosis of certain diseases.However,the bulky nature of commercial flow cytometers makes such tests only available in hospitals or laboratories,hindering the spread of point-of-care testing(POCT),especially in underdeveloped areas.Here,we propose a smart Palm-size Optofluidic Hematology Analyzer based on a miniature fluorescence microscope and a microfluidic platform to lighten the device to improve its portability.This gadget has a dimension of 35×30×80 mm and a mass of 39 g,less than 5%of the weight of commercially available flow cytometers.Additionally,automatic leukocyte concentration detection has been realized through the integration of image processing and leukocyte counting algorithms.We compared the leukocyte concentration measurement between our approach and a hemocytometer using the Passing-Bablok analysis and achieved a correlation coefficient of 0.979.Through Bland-Altman analysis,we obtained the relationship between their differences and mean measurement values and established 95%limits of agreement,ranging from−0.93×10^(3)to 0.94×10^(3)cells/μL.We anticipate that this device can be used widely for monitoring and treating diseases such as HIV and tumors beyond hospitals. 展开更多
关键词 hematology analyzer miniature fluorescence microscope MICROFLUIDICS leukocyte concentration
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