MATHEMATICAL MODELING AND BIFURCATION ANALYSIS FOR A BIOLOGICAL MECHANISM OF CANCER DRUG RESISTANCE

Drug resistance is one of the most intractable issues in targeted therapy for cancer diseases.It has also been demonstrated to be related to cancer heterogeneity,which promotes the emergence of treatment-refractory cancer cell populations.Focusing on how cancer cells develop resistance during the encounter with targeted drugs and the immune system,we propose a mathematical model for studying the dynamics of drug resistance in a conjoint heterogeneous tumor-immune setting.We analyze the local geometric properties of the equilibria of the model.Numerical simulations show that the selectively targeted removal of sensitive cancer cells may cause the initially heterogeneous population to become a more resistant population.Moreover,the decline of immune recruitment is a stronger determinant of cancer escape from immune surveillance or targeted therapy than the decay in immune predation strength.Sensitivity analysis of model parameters provides insight into the roles of the immune system combined with targeted therapy in determining treatment outcomes.

Global Piecewise Analysis of HIV Model with Bi-Infectious Categories under Ordinary Derivative and Non-Singular Operator with Neural Network Approach

This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu(AB)derivatives having arbitrary order.The HIV infection model has a susceptible class,a recovered class,along with a case of infection divided into three sub-different levels or categories and the recovered class.The total time interval is converted into two,which are further investigated for ordinary and fractional order operators of the AB derivative,respectively.The proposed model is tested separately for unique solutions and existence on bi intervals.The numerical solution of the proposed model is treated by the piece-wise numerical iterative scheme of Newtons Polynomial.The proposed method is established for piece-wise derivatives under natural order and non-singular Mittag-Leffler Law.The cross-over or bending characteristics in the dynamical system of HIV are easily examined by the aspect of this research having a memory effect for controlling the said disease.This study uses the neural network(NN)technique to obtain a better set of weights with low residual errors,and the epochs number is considered 1000.The obtained figures represent the approximate solution and absolute error which are tested with NN to train the data accurately.

MATHEMATICAL FOUNDATION OF A NEW COMPLEXITY MEASURE

For many continuous bio-medieal signals with both strong nonlinearity and non-stationarity, two criterions were proposed for their complexity estimation ： （1） Only a short data set is enough for robust estimation; （2） No over-coarse graining preproeessing, such as transferring the original signal into a binary time series, is needed. Co complexity measure proposed by us previously is one of such measures. However, it lacks the solid mathematical foundation and thus its use is limited. A modified version of this measure is proposed, and some important properties are proved rigorously. According to these properties, this measure can be considered as an index of randomness of time series in some senses, and thus also a quantitative index of complexity under the meaning of randomness finding complexity. Compared with other similar measures, this measure seems more suitable for estimating a large quantity of complexity measures for a given task, such as studying the dynamic variation of such measures in sliding windows of a long process, owing to its fast speed for estimation.

Mathematical Proof of the Synthetic Running Correlation Coefficient and Its Ability to Reflect Temporal Variations in Correlation

The running correlation coefficient(RCC)is useful for capturing temporal variations in correlations between two time series.The local running correlation coefficient(LRCC)is a widely used algorithm that directly applies the Pearson correlation to a time window.A new algorithm called synthetic running correlation coefficient(SRCC)was proposed in 2018 and proven to be rea-sonable and usable;however,this algorithm lacks a theoretical demonstration.In this paper,SRCC is proven theoretically.RCC is only meaningful when its values at different times can be compared.First,the global means are proven to be the unique standard quantities for comparison.SRCC is the only RCC that satisfies the comparability criterion.The relationship between LRCC and SRCC is derived using statistical methods,and SRCC is obtained by adding a constraint condition to the LRCC algorithm.Dividing the temporal fluctuations into high-and low-frequency signals reveals that LRCC only reflects the correlation of high-frequency signals;by contrast,SRCC reflects the correlations of high-and low-frequency signals simultaneously.Therefore,SRCC is the ap-propriate method for calculating RCCs.

Hamiltonian system for the inhomogeneous plane elasticity of dodecagonal quasicrystal plates and its analytical solutions

A Hamiltonian system is derived for the plane elasticity problem of two-dimensional dodecagonal quasicrystals by introducing the simple state function. By using symplectic elasticity approach, the analytic solutions of the phonon and phason displacements are obtained further for the quasicrystal plates. In addition, the effectiveness of the approach is verified by comparison with the data of the finite integral transformation method.

Dispersive propagation of optical solitions and solitary wave solutions of Kundu-Eckhaus dynamical equation via modified mathematical method

In this research work,we constructed the optical soliton solutions of nonlinear complex Kundu-Eckhaus(KE)equation with the help of modified mathematical method.We obtained the solutions in the form of dark solitons,bright solitons and combined dark-bright solitons,travelling wave and periodic wave solutions with general coefficients.In our knowledge earlier reported results of the KE equation with specific coefficients.These obtained solutions are more useful in the development of optical fibers,dynamics of solitons,dynamics of adiabatic parameters,dynamics of fluid,problems of biomedical,industrial phenomena and many other branches.All calculations show that this technique is more powerful,effective,straightforward,and fruitfulness to study analytically other higher-order nonlinear complex PDEs involves in mathematical physics,quantum physics,Geo physics,fluid mechanics,hydrodynamics,mathematical biology,field of engineering and many other physical sciences.

A Mathematical Interpretation of Hawking’s Black Hole Theory by Ricci Flow

In this paper, using Perelman’s no local collapsing theorem and the geometric interpretation of Hamilton’s Harnack expressions along the Ricci flow introduced by R. Hamilton, we present a mathematical interpretation of Hawking’s black hole theory in [1].

The Mathematical Model of Short-Term Forest Fire Spread

In this paper, we establish a mathematical model of the forest fire spread process based on a partial differential equation. We describe the distribution of time field and velocity field in the whole two-dimensional space by vector field theory. And we obtain a continuous algorithm to predict the dynamic behavior of forest fire spread in a short time. We use the algorithm to interpolate the fire boundary by cubic non-uniform rational B-spline closed curve. The fire boundary curve at any time can be simulated by solving the Eikonal equation. The model is tested in theory and in practice. The results show that the model has good accuracy and stability, and it’s compatible with most of the existing models, such as the elliptic model and the cellular automata model.

CONVERGENCE OF A QUANTUM LATTICE BOLTZMANN SCHEME TO THE NONLINEAR DIRAC EQUATION FOR GROSS-NEVEU MODEL IN 1+1 DIMENSIONS

This paper studies the strong convergence of the quantum lattice Boltzmann(QLB)scheme for the nonlinear Dirac equations for Gross-Neveu model in 1+1 dimensions.The initial data for the scheme are assumed to be convergent in L^(2).Then for any T≥0 the corresponding solutions for the quantum lattice Boltzmann scheme are shown to be convergent in C([0,T];L^(2)(R^(1)))to the strong solution to the nonlinear Dirac equations as the mesh sizes converge to zero.In the proof,at first a Glimm type functional is introduced to establish the stability estimates for the difference between two solutions for the corresponding quantum lattice Boltzmann scheme,which leads to the compactness of the set of the solutions for the quantum lattice Boltzmann scheme.Finally the limit of any convergent subsequence of the solutions for the quantum lattice Boltzmann scheme is shown to coincide with the strong solution to a Cauchy problem for the nonlinear Dirac equations.

Efficient method to calculate the eigenvalues of the Zakharov–Shabat system

A numerical method is proposed to calculate the eigenvalues of the Zakharov–Shabat system based on Chebyshev polynomials. A mapping in the form of tanh(ax) is constructed according to the asymptotic of the potential function for the Zakharov–Shabat eigenvalue problem. The mapping can distribute Chebyshev nodes very well considering the gradient for the potential function. Using Chebyshev polynomials, tanh(ax) mapping, and Chebyshev nodes, the Zakharov–Shabat eigenvalue problem is transformed into a matrix eigenvalue problem. This method has good convergence for the Satsuma–Yajima potential and the convergence rate is faster than the Fourier collocation method. This method is not only suitable for simple potential functions but also converges quickly for a complex Y-shape potential. It can also be further extended to other linear eigenvalue problems.

Effects of asymmetric coupling and boundary on the dynamic behaviors of a random nearest neighbor coupled system

This study investigates the dynamical behaviors of nearest neighbor asymmetric coupled systems in a confined space.First, the study derivative analytical stability and synchronization conditions for the asymmetrically coupled system in an unconfined space, which are then validated through numerical simulations. Simulation results show that asymmetric coupling has a significant impact on synchronization conditions. Moreover, it is observed that irrespective of whether the system is confined, an increase in coupling asymmetry leads to a hastened synchronization pace. Additionally, the study examines the effects of boundaries on the system's collective behaviors via numerical experiments. The presence of boundaries ensures the system's stability and synchronization, and reducing these boundaries can expedite the synchronization process and amplify its effects. Finally, the study reveals that the system's output amplitude exhibits stochastic resonance as the confined boundary size increases.

Presentation of the Berry-Tabor conjecture in Levy plates

The Berry-Tabor(BT)conjecture is a famous statistical inference in quantum chaos,which not only establishes the spectral fluctuations of quantum systems whose classical counterparts are integrable but can also be used to describe other wave phenomena.In this paper,the BT conjecture has been extended to Lévy plates.As predicted by the BT conjecture,level clustering is present in the spectra of Lévy plates.The consequence of level clustering is studied by introducing the distribution of nearest neighbor frequency level spacing ratios P(r),which is calculated through the analytical solution obtained by the Hamiltonian approach.Our work investigates the impact of varying foundation parameters,rotary inertia,and boundary conditions on the frequency spectra,and we find that P(r)conforms to a Poisson distribution in all cases.The reason for the occurrence of the Poisson distribution in the Lévy plates is the independence between modal frequencies,which can be understood through mode functions.

THE GRADIENT ESTIMATE OF SUBELLIPTIC HARMONIC MAPS WITH A POTENTIAL

In this paper,we investigate subelliptic harmonic maps with a potential from noncompact complete sub-Riemannian manifolds corresponding to totally geodesic Riemannian foliations.Under some suitable conditions,we give the gradient estimates of these maps and establish a Liouville type result.

ON THE STABILITY OF PERIODIC SOLUTIONS OF PIECEWISE SMOOTH PERIODIC DIFFERENTIAL EQUATIONS

In this paper,we address the stability of periodic solutions of piecewise smooth periodic differential equations.By studying the Poincarémap,we give a sufficient condition to judge the stability of a periodic solution.We also present examples of some applications.

STABILITY OF TRANSONIC SHOCKS TO THE EULER-POISSON SYSTEM WITH VARYING BACKGROUND CHARGES

This paper is devoted to studying the stability of transonic shock solutions to the Euler-Poisson system in a one-dimensional nozzle of finite length.The background charge in the Poisson equation is a piecewise constant function.The structural stability of the steady transonic shock solution is obtained by the monotonicity argument.Furthermore,this transonic shock is proved to be dynamically and exponentially stable with respect to small perturbations of the initial data.One of the crucial ingredients of the analysis is to establish the global well-posedness of a free boundary problem for a quasilinear second order equation with nonlinear boundary conditions.

THE EXISTENCE AND UNIQUENESS OF TIME-PERIODIC SOLUTIONS TO THE NON-ISOTHERMAL MODEL FOR COMPRESSIBLE NEMATIC LIQUID CRYSTALS IN A PERIODIC DOMAIN

In this paper,we are concerned with a three-dimensional non-isothermal model for the compressible nematic liquid crystal flows in a periodic domain.Under some smallness and structural assumptions imposed on the time-periodic force,we establish the existence of the time-periodic solutions to the system by using a regularized approximation scheme and the topological degree theory.We also prove a uniqueness result via energy estimates.

THE HOLDER CONTINUITY OF THE LYAPUNOV EXPONENT FOR A QUASI-PERIODIC SZEGO COCYCLE

In this paper,I consider the Hölder continuity of the Lyapunov exponent for a quasi-periodic Szegö cocycle with weak Liouville frequency.I extend the existing results about the regularity of the Lyapunov exponent from the Schrödinger cocycle in[24]to a Szegö cocycle.

Dilation,discrimination and Uhlmann's theorem of link products of quantum channels

We establish the Stinespring dilation theorem of the link product of quantum channels in two different ways,discuss the discrimination of quantum channels,and show that the distinguishability can be improved by self-linking each quantum channel n times as n grows.We also find that the maximum value of Uhlmann's theorem can be achieved for diagonal channels.

On entire solutions of some Fermat type differential-difference equations

On one hand,we study the existence of transcendental entire solutions with finite order of the Fermat type difference equations.On the other hand,we also investigate the existence and growth of solutions of nonlinear differential-difference equations.These results extend and improve some previous in[5,14].

ENTIRE SOLUTIONS OF HIGHER ORDER DIFFERENTIAL EQUATIONS WITH ENTIRE COEFFICIENTS HAVING THE SAME ORDER

In this paper,we consider entire solutions of higher order homogeneous differential equations with the entire coefficients having the same order,and prove that the entire solutions are of infinite lower order.The properties on the radial distribution,the limit direction of the Julia set and the existence of a Baker wandering domain of the entire solutions are also discussed.