Parkinson's disease(PD),diffuse Lewy body disease(DLBD),and multiple system atrophy(MSA)are major neurodegenerative disorders;they are synucleinopathies,whose pathogenesis is due to the aggregation ofα-synuclein(...Parkinson's disease(PD),diffuse Lewy body disease(DLBD),and multiple system atrophy(MSA)are major neurodegenerative disorders;they are synucleinopathies,whose pathogenesis is due to the aggregation ofα-synuclein(α-syn)[1].α-syn is a 140 amino acid presynaptic protein that is composed of three domains:the N-terminal region[amino-acids(AA)1-60];the central domain with a non-Aβcomponent(AA 61-95),and the C-terminal acidic carboxyl-terminal tail(AA 96-140)[2].The structure of the protein exhibits different forms such as monomers,oligomers,fibrils,or fibers,which largely depend on the intracellular environment.Under pathological circumstances,monomericα-syn tends to form amyloid fibrils which finally condense into Lewy bodies[3].展开更多
基金supported by the Scientific Research Foundation for Scholars of Hangzhou Normal University(4125C5021920453 and 4125C50220204109).
文摘Parkinson's disease(PD),diffuse Lewy body disease(DLBD),and multiple system atrophy(MSA)are major neurodegenerative disorders;they are synucleinopathies,whose pathogenesis is due to the aggregation ofα-synuclein(α-syn)[1].α-syn is a 140 amino acid presynaptic protein that is composed of three domains:the N-terminal region[amino-acids(AA)1-60];the central domain with a non-Aβcomponent(AA 61-95),and the C-terminal acidic carboxyl-terminal tail(AA 96-140)[2].The structure of the protein exhibits different forms such as monomers,oligomers,fibrils,or fibers,which largely depend on the intracellular environment.Under pathological circumstances,monomericα-syn tends to form amyloid fibrils which finally condense into Lewy bodies[3].
