Quantitative trait loci (QTL) and their additive, dominance and epistatic effects play a critical role in complex trait variation. It is often infeasible to detect multiple interacting QTL due to main effects often be...Quantitative trait loci (QTL) and their additive, dominance and epistatic effects play a critical role in complex trait variation. It is often infeasible to detect multiple interacting QTL due to main effects often being confounded by interaction effects. Positioning interacting QTL within a small region is even more difficult. We present a variance component approach nested in an empirical Bayesian method, which simultaneously takes into account additive, dominance and epistatic effects due to multiple interacting QTL. The covariance structure used in the variance component approach is based on combined linkage disequilibrium and linkage (LDL) information. In a simulation study where there are complex epistatic interactions between QTL, it is possible to simultaneously fine map interacting QTL using the proposed approach. The present method combined with LDL information can efficiently detect QTL and their dominance and epistatic effects, making it possible to simultaneously fine map main and epistatic QTL.展开更多
This study examined the effects of sources and levels of selenium(Se)on performance,carcass parts yield,meat quality and tissue Se concentration in broilers.A total of 960 one-day-old male broilers were divided into 8...This study examined the effects of sources and levels of selenium(Se)on performance,carcass parts yield,meat quality and tissue Se concentration in broilers.A total of 960 one-day-old male broilers were divided into 8 treatments in a 4 x 2 factorial arrangement.Chicks were penned in groups of 20 with6 pens per group.Selenium sources were sodium selenite(SS),Se enriched yeast(SY),DLselenomethionine(SM)and nano-selenium(NS)and dietary supplemental Se levels were 0.1 and0.3 mg/kg diet.The average daily gain(ADG),average daily feed intake(ADFI),feed:gain ratio,mortality,and carcass parts yield were not affected by dietary treatments.The level of 0.3 mg/kg Se decreased lightness and increased yellowness of the breast and thighs(P<0.001).Nano-selenium improved yellowness,redness and meat quality(P<0.05).The interactive effects of sources and the levels of Se affected Se retention(P<0.001).Inorganic Se showed poor retention compared to other sources of Se;and NS showed equal retention with the organic sources.With consideration to meat quality responses,NS had a more signific:ant positive effect compared to SS as an inorganic source of Se.Overall,NS and organic sources of Se resulted in better meat quality compared with the inorganic source.Moreover,the highest Se retention percentage was achieved by supplementation of NS followed by organic sources at0.1 mg/kg compared to SS.展开更多
基金Project supported by the International Pig Improvement Company(PIC) and Sheep Genomics, Australia
文摘Quantitative trait loci (QTL) and their additive, dominance and epistatic effects play a critical role in complex trait variation. It is often infeasible to detect multiple interacting QTL due to main effects often being confounded by interaction effects. Positioning interacting QTL within a small region is even more difficult. We present a variance component approach nested in an empirical Bayesian method, which simultaneously takes into account additive, dominance and epistatic effects due to multiple interacting QTL. The covariance structure used in the variance component approach is based on combined linkage disequilibrium and linkage (LDL) information. In a simulation study where there are complex epistatic interactions between QTL, it is possible to simultaneously fine map interacting QTL using the proposed approach. The present method combined with LDL information can efficiently detect QTL and their dominance and epistatic effects, making it possible to simultaneously fine map main and epistatic QTL.
文摘This study examined the effects of sources and levels of selenium(Se)on performance,carcass parts yield,meat quality and tissue Se concentration in broilers.A total of 960 one-day-old male broilers were divided into 8 treatments in a 4 x 2 factorial arrangement.Chicks were penned in groups of 20 with6 pens per group.Selenium sources were sodium selenite(SS),Se enriched yeast(SY),DLselenomethionine(SM)and nano-selenium(NS)and dietary supplemental Se levels were 0.1 and0.3 mg/kg diet.The average daily gain(ADG),average daily feed intake(ADFI),feed:gain ratio,mortality,and carcass parts yield were not affected by dietary treatments.The level of 0.3 mg/kg Se decreased lightness and increased yellowness of the breast and thighs(P<0.001).Nano-selenium improved yellowness,redness and meat quality(P<0.05).The interactive effects of sources and the levels of Se affected Se retention(P<0.001).Inorganic Se showed poor retention compared to other sources of Se;and NS showed equal retention with the organic sources.With consideration to meat quality responses,NS had a more signific:ant positive effect compared to SS as an inorganic source of Se.Overall,NS and organic sources of Se resulted in better meat quality compared with the inorganic source.Moreover,the highest Se retention percentage was achieved by supplementation of NS followed by organic sources at0.1 mg/kg compared to SS.
