AIM: To investigate the clinical features, diagnosis,treatment and prognosis of multiple primary colorectal carcinomas (MPCC). METHODS: A retrospective analysis of 37 patients with MPCC from 1974 to 1998 was carried o...AIM: To investigate the clinical features, diagnosis,treatment and prognosis of multiple primary colorectal carcinomas (MPCC). METHODS: A retrospective analysis of 37 patients with MPCC from 1974 to 1998 was carried out.RESULTS: The incidence of MPCC was 2.74%(37/1 348) in patients with primary colorectal carcinomas, 15 cases of them were patients with synchronous carcinomas (SC) and 22 cases were diagnosed as metachronous carcinomas (MC). Most tumors were located in the right colon and rectum. Fifty-five percent (12/22) of MC were diagnosed within 3 years after tumor resection and 41%(9/22) of MC occurred after 8 years. Radical resections were performed in all patients except for 1 case. The 5-year survival rate of SC was 72.7%(8/11) and that of MC after the first cancer and second cancer was 71.4%(15/21) and 38.9%(7/18), respectively. CONCLUSION: The results indicate the importance of complete preoperative examination, careful intraoperative exploration and periodic postoperative surveillance. Early diagnosis and radical resection can increase survival rate of MPCC.展开更多
In advancing gastric cancer,especially when the serous is invaded,the plantation of cancer cells in peritoneal is common and it affects patients' survival time severely.Based on sucessfully labeled McAb(monoclonal...In advancing gastric cancer,especially when the serous is invaded,the plantation of cancer cells in peritoneal is common and it affects patients' survival time severely.Based on sucessfully labeled McAb(monoclonal antibody) 3H11 with ^188Re,we investigated the effect of RIT(Radioimmuno-Therapy) with ^188Re-3H11 on preventing the survival time,After 1×10^6 BGC-823 gastric cancer cells were injected into the peritoneal cavity of each mouse,45MABL/C nude mice were divided into 9 groups.Each group received different doses of ^188Re-3Hll or 188Re-IgG,or saline I.P.16 hours postoperation.The injected volume of each mouse was 1.0mL.The results showed that the survival time depended on the injected doses during 0 to 37MBq.The survival time was 170±25.3d after 37MBq 188^Re-3H11 were treated.It was over 5 times more than that for the saline gro9up and about 3 times more than that for 37MBq 188-Re IgG group(P<0.05),The mice hemogram were reduced to lowest 14days after injection,but they recovered after 38d.Conclusion:with proper injection doses,early postoperative ^188Re-3H11 I.P.is effective and safe for the prevention of intra-peritoneally injected gastric cancer cells from surviving,growing and disseminating in nude mice.展开更多
文摘AIM: To investigate the clinical features, diagnosis,treatment and prognosis of multiple primary colorectal carcinomas (MPCC). METHODS: A retrospective analysis of 37 patients with MPCC from 1974 to 1998 was carried out.RESULTS: The incidence of MPCC was 2.74%(37/1 348) in patients with primary colorectal carcinomas, 15 cases of them were patients with synchronous carcinomas (SC) and 22 cases were diagnosed as metachronous carcinomas (MC). Most tumors were located in the right colon and rectum. Fifty-five percent (12/22) of MC were diagnosed within 3 years after tumor resection and 41%(9/22) of MC occurred after 8 years. Radical resections were performed in all patients except for 1 case. The 5-year survival rate of SC was 72.7%(8/11) and that of MC after the first cancer and second cancer was 71.4%(15/21) and 38.9%(7/18), respectively. CONCLUSION: The results indicate the importance of complete preoperative examination, careful intraoperative exploration and periodic postoperative surveillance. Early diagnosis and radical resection can increase survival rate of MPCC.
文摘In advancing gastric cancer,especially when the serous is invaded,the plantation of cancer cells in peritoneal is common and it affects patients' survival time severely.Based on sucessfully labeled McAb(monoclonal antibody) 3H11 with ^188Re,we investigated the effect of RIT(Radioimmuno-Therapy) with ^188Re-3H11 on preventing the survival time,After 1×10^6 BGC-823 gastric cancer cells were injected into the peritoneal cavity of each mouse,45MABL/C nude mice were divided into 9 groups.Each group received different doses of ^188Re-3Hll or 188Re-IgG,or saline I.P.16 hours postoperation.The injected volume of each mouse was 1.0mL.The results showed that the survival time depended on the injected doses during 0 to 37MBq.The survival time was 170±25.3d after 37MBq 188^Re-3H11 were treated.It was over 5 times more than that for the saline gro9up and about 3 times more than that for 37MBq 188-Re IgG group(P<0.05),The mice hemogram were reduced to lowest 14days after injection,but they recovered after 38d.Conclusion:with proper injection doses,early postoperative ^188Re-3H11 I.P.is effective and safe for the prevention of intra-peritoneally injected gastric cancer cells from surviving,growing and disseminating in nude mice.
