A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B3 （CVB3） activity was evaluated in VERO ceils. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavi...A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B3 （CVB3） activity was evaluated in VERO ceils. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin （RBV） with IC50 values of 5.30 and 1.06 μg/mL, respectively. ？2009 Xian Jin Luo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
A series of new benzimidazole derivatives were designed and synthesized.Their chemical structures were testified by 1 H NMR,infrared spectroscopy(IR),mass spectrography(MS),and elemental analysis.Their potent antivira...A series of new benzimidazole derivatives were designed and synthesized.Their chemical structures were testified by 1 H NMR,infrared spectroscopy(IR),mass spectrography(MS),and elemental analysis.Their potent antiviral properties indicated the prospect of new drugs.Compound 13,16,18,19,21,22,and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B_(3) in VERO cells.展开更多
文摘A series of novel benzimidazole derivatives was synthesized and their anti-Coxsackie virus B3 （CVB3） activity was evaluated in VERO ceils. Compounds 9 and 10 exhibited better inhibitory activity than those of ribavirin （RBV） with IC50 values of 5.30 and 1.06 μg/mL, respectively. ？2009 Xian Jin Luo. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘A series of new benzimidazole derivatives were designed and synthesized.Their chemical structures were testified by 1 H NMR,infrared spectroscopy(IR),mass spectrography(MS),and elemental analysis.Their potent antiviral properties indicated the prospect of new drugs.Compound 13,16,18,19,21,22,and 23 were identified as novel antivirus with much better selective activity and inhibitory activity than the comparable ribavirin against Coxsackie virus B_(3) in VERO cells.
