The effects of genomic variations and their associations with idiopathic scoliosis have been the discussion of many research trials. Previous investigations into catechol-o-methyl transferase (COMT) have identified it...The effects of genomic variations and their associations with idiopathic scoliosis have been the discussion of many research trials. Previous investigations into catechol-o-methyl transferase (COMT) have identified its importance in dopamine and estrogen metabolism. While many genetic influences on idiopathic scoliosis have been observed, there has been no report of any relationship between COMT mutations and idiopathic scoliosis. The present study compared two groups of patients who received COMT genetic testing. The first group had a history of idiopathic scoliosis, while the other served as a non-scoliotic control group. The scoliosis group showed a positive COMT mutation in 33 out of 58 patients, while the control group showed 22/58 (P < 0.05). The homozygous genotype Met/Met occurred significantly more frequently in the scoliosis group. The increased incidence of COMT defects in the current scoliosis patient group warrants further study into how COMT variations may relate to the development or progression of idiopathic scoliosis.展开更多
文摘The effects of genomic variations and their associations with idiopathic scoliosis have been the discussion of many research trials. Previous investigations into catechol-o-methyl transferase (COMT) have identified its importance in dopamine and estrogen metabolism. While many genetic influences on idiopathic scoliosis have been observed, there has been no report of any relationship between COMT mutations and idiopathic scoliosis. The present study compared two groups of patients who received COMT genetic testing. The first group had a history of idiopathic scoliosis, while the other served as a non-scoliotic control group. The scoliosis group showed a positive COMT mutation in 33 out of 58 patients, while the control group showed 22/58 (P < 0.05). The homozygous genotype Met/Met occurred significantly more frequently in the scoliosis group. The increased incidence of COMT defects in the current scoliosis patient group warrants further study into how COMT variations may relate to the development or progression of idiopathic scoliosis.
