Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics.Here,we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory ...Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics.Here,we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a at Lys119.The 0RF7a polyubiquitination is primarily formed by K63-linked ubiquitin chains.展开更多
文摘Understanding interactions between the host and SARS-CoV-2 is essential for developing effective vaccines and therapeutics.Here,we report that SARS-CoV-2 usurps the host ubiquitin system to polyubiquitinate accessory protein ORF7a at Lys119.The 0RF7a polyubiquitination is primarily formed by K63-linked ubiquitin chains.