Aim-To evaluate the relationship between histopathology results and magnetic resonance imaging (MRI) on in-and opposed-phase sequences grading of fat deposition within human liver. Materials and methods-In-and opposed...Aim-To evaluate the relationship between histopathology results and magnetic resonance imaging (MRI) on in-and opposed-phase sequences grading of fat deposition within human liver. Materials and methods-In-and opposed-phase T1-weighted gradient-echo sequences (double echo time 2.3 ms and 4.6ms)were performed in 25 patients,using a 1.5-T clinical MR imaging system. Fat/water ratio on in-and opposed-phase images of the liver was compared with pathologically defined degree or steatosis. The signal intensity in the images was acquired with operator-defined regions of interest at the same location in both fat and water images and the ratio was calculated by dividing signal intensity of liver in opposed phased sequence on signal intensity of liver in phased sequence. Fat/water ratio and the degree of steatosis were compared using linear regression. The sensitivity and specificity of opposed-phase for diagnosing steatosis were defined by ROC analysis. Furthermore, a correlation between visual signal intensity variation (SIV)and the degree of steatosis was assessed using Pearson correlation coefficient. Results-Histology demonstrated fatty liver infiltrations in 81 %of specimens. The percentage of fatty hepatocytes was 28 +/-30 %. Fat/water ratio was significantly correlated with the pathologic grading of steatosis (r = 0.816, P < 0.001). The opposed phase MR imaging sensibility and specificity for the diagnosis of hepatic steatosis were respectively 80%and 71%. We obtained a statistically significant correlation between visual SIV and fatty liver grading (P = 0.017). Conclusion-We demonstrated a significant correlation between fat/water ratio and histological findings for the detection and grading of fatty liver.展开更多
Objectives-The aim of this study was to assess the accuracy of water enema multi-row computed tomography for detecting clinically suspected colorectal tumor.Patients and methods-A water enema multi-row computed tomogr...Objectives-The aim of this study was to assess the accuracy of water enema multi-row computed tomography for detecting clinically suspected colorectal tumor.Patients and methods-A water enema multi-row computed tomography(WE-MR-CT)was performed in 128 consecutive patients(71 women,mean age 67.7 years)referred for suspicion of colorectal cancer.We defined at least one centimeter size of the lesion as the threshold of detection.The results of WE-MR-CT were compared with the diagnosis obtained by colonoscopy,pathology or clinical follow-up.Results-The overall sensitivity and specificity of water enema multi-row CT in identifying patients with colorectal lesions were 95.5%and 93.5%,respectively.The negative predictive value was 98.8%for a 10-mm threshold lesion size.WE-MR-CT allowed identifying synchronous lesions in three cases.Conclusions-WE-MR-CT can accurately detect supracentimetric colorectal tumors.The performance of this technique should be further evaluated in prospective studies.展开更多
文摘Aim-To evaluate the relationship between histopathology results and magnetic resonance imaging (MRI) on in-and opposed-phase sequences grading of fat deposition within human liver. Materials and methods-In-and opposed-phase T1-weighted gradient-echo sequences (double echo time 2.3 ms and 4.6ms)were performed in 25 patients,using a 1.5-T clinical MR imaging system. Fat/water ratio on in-and opposed-phase images of the liver was compared with pathologically defined degree or steatosis. The signal intensity in the images was acquired with operator-defined regions of interest at the same location in both fat and water images and the ratio was calculated by dividing signal intensity of liver in opposed phased sequence on signal intensity of liver in phased sequence. Fat/water ratio and the degree of steatosis were compared using linear regression. The sensitivity and specificity of opposed-phase for diagnosing steatosis were defined by ROC analysis. Furthermore, a correlation between visual signal intensity variation (SIV)and the degree of steatosis was assessed using Pearson correlation coefficient. Results-Histology demonstrated fatty liver infiltrations in 81 %of specimens. The percentage of fatty hepatocytes was 28 +/-30 %. Fat/water ratio was significantly correlated with the pathologic grading of steatosis (r = 0.816, P < 0.001). The opposed phase MR imaging sensibility and specificity for the diagnosis of hepatic steatosis were respectively 80%and 71%. We obtained a statistically significant correlation between visual SIV and fatty liver grading (P = 0.017). Conclusion-We demonstrated a significant correlation between fat/water ratio and histological findings for the detection and grading of fatty liver.
文摘Objectives-The aim of this study was to assess the accuracy of water enema multi-row computed tomography for detecting clinically suspected colorectal tumor.Patients and methods-A water enema multi-row computed tomography(WE-MR-CT)was performed in 128 consecutive patients(71 women,mean age 67.7 years)referred for suspicion of colorectal cancer.We defined at least one centimeter size of the lesion as the threshold of detection.The results of WE-MR-CT were compared with the diagnosis obtained by colonoscopy,pathology or clinical follow-up.Results-The overall sensitivity and specificity of water enema multi-row CT in identifying patients with colorectal lesions were 95.5%and 93.5%,respectively.The negative predictive value was 98.8%for a 10-mm threshold lesion size.WE-MR-CT allowed identifying synchronous lesions in three cases.Conclusions-WE-MR-CT can accurately detect supracentimetric colorectal tumors.The performance of this technique should be further evaluated in prospective studies.
