Cell replacement therapy has long been proposed as a treatment for the damaged nervous system.One of the most challenging aspects of such a strategy,however,is finding sources of donor cells for transplantation.Autolo...Cell replacement therapy has long been proposed as a treatment for the damaged nervous system.One of the most challenging aspects of such a strategy,however,is finding sources of donor cells for transplantation.Autologous neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be removed.One possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long term.Methodological improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.展开更多
基金supported by projects NDG09/014 and Proyecto VEXEM(to CLP),European Social Fund,YEI,(Nos.PEJ16/MED/AI-1153 and PEJD-2018-PRE/SAL-8532)of the Community of Madrid,SpainSAF-2016-78666-R,CP19-0010,and PID 2020-113014RB-I00 funded by MCIN/AEI/10.13039/501100011033(to JARN).
文摘Cell replacement therapy has long been proposed as a treatment for the damaged nervous system.One of the most challenging aspects of such a strategy,however,is finding sources of donor cells for transplantation.Autologous neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be removed.One possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long term.Methodological improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.
