Effect of auricular plaster for primary hypertension in older people:A meta-analysis

BACKGROUND Hypertension is a critical public health problem globally.Antihypertensive drugs can create an extra burden on hypertension patients'self-regulation leading to an imbalance of blood supply and demand.This study aimed to evaluate the effect of auricular plaster therapy combined with western medicine to treat primary hypertension in older people.AIM To carry out a systematic review and meta-analysis for the effect of auricular plaster in elderly hypertension patients.METHODS Multiple databases like PubMed,EMBASE,Cochrane Library,Chinese Biomedical Literature on Disc,China National Knowledge Infrastructure,Wan Fang and Chinese Science and Technology Periodical Database were used to search for the relevant studies and full-text articles involved in the evaluation of auricular plaster combined with western medicine and western medicine alone for primary hypertension in older people.All included articles were quality assessed and the data analysis was conducted with the Review Manager(5.4).Forest plots,sensitivity analysis and funnel plots were also performed on the included articles.RESULTS In this analysis,fourteen(14)relevant studies were included.The Meta-analysis showed a significant difference in the effective ratio(OR=3.62;95%CI,2.46 to 5.33;P<0.00001),diastolic blood pressure change(5.68 mmHg;95%CI,3.49 to 7.87;P<0.00001),systolic blood pressure change(MD=8.78 mmHg;95%CI,5.04 to 12.53;P<0.00001)and symptom score(MD=3.20;95%CI,1.23 to 5.18;P=0.001)between auricular plaster combined with western medicine group and western medicine alone group.One bias was detected as selection bias and another two in reporting bias.Sensitivity analysis fulfilled the stability of the results.CONCLUSION Our study suggested that auricular plaster combined with western medicine improved primary hypertension better than western medicine alone.Limited by the quality of included studies,further studies should be performed to confirm our findings.

Clinical study about the effect of Simiao Yong'an Decoction on preventing in-stent restenosis and regulating inflammation and oxidative stress after lower extremity stent angioplasty stenting

Objective:To study the effect of Simiao Yong'an Decoction on the prevention of in-stent restenosis and the regulation of inflammation and oxidative stress after lower extremity stent angioplasty.Methods:A prospective study was conducted on 60 ASO patients who underwent lower extremity stent angioplasty in our hospital between January 2014 and January 2018.The patients were randomly divided into observation group receiving postoperative Simiao Yong'an Decoction combined with antiplatelet drug treatment and control group receiving postoperative antiplatelet drug treatment.The conditions of in-stent restenosis were followed up,and the indicators of coagulation,inflammation and oxidative stress were detected.Results:The incidence of in-stent restenosis in observation group 1 year after operation was significantly lower than that in control group;6 months and 12 months after operation,the ankle brachial index(ABI)levels,minimal lumen diameter(MLD)levels at the stent and superoxide dismutase(SOD)contents of observation group were significantly higher than those of control group,whereas D-dimer(D-D)and fibrinogen degradation product(FDP)levels as well as P-selectin,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),malondialdehyde(MDA)and inducible nitric oxide synthase(iNOS)contents were significantly lower than those of control group.Conclusions:Simiao Yong'an Decoction can prevent the in-stent restenosis and inhibit the inflammation and oxidative stress after lower extremity stent angioplasty.

Assessment of the inflammatory factor as well as invasion and apoptosis gene expression in endometriosis model rats after mifepristone intervention

Objective:To study the effect of mifepristone intervention on the inflammatory factor as well as invasion and apoptosis gene expression in endometriosis lesions of endometriosis model rats.Method:SD female rats were selected as experimental animals, divided into model group (EMs group) and mifepristone group (RU486 group) and made into endometriosis models, then the EMs group received saline intervention and RU486 group received 2.6 mg/kg/d RU486 intervention. 4 weeks after intervention, endometriosis lesions were anatomized to determine the expression of inflammatory factors (COX-2, PGE2, TNF-α, IL-1β and IL-6), invasion genes (OPN, MMP2, MMP9, uPA and S100A6) as well as apoptosis genes (Bcl-2, Livin, Smac and PTEN).Results: COX-2, PGE2, TNF-α, IL-1β, IL-6, OPN, MMP2, MMP9, uPA, S100A6, Bcl-2 and Livin protein expression in endometriosis lesions of Ru486 group were significantly lower than those of EMs group while Smac and PTEN protein expression were higher than those of EMs group.Conclusion: Mifepristone for endometriosis model rats can inhibit the expression of inflammatory factors, invasion genes and anti-apoptosis genes, and increase the expression of pro-apoptosis genes.

The correlation between serum MR-proANP and neurohumoral system change in patients with acute myocardial infarction

Objective:To study the correlation between serum midregional pro-atrial natriuretic peptide (MR-proANP) and neurohumoral system change in patients with acute myocardial infarction (AMI).Methods:A total of 56 patients who were diagnosed with acute myocardial infarction in our hospital between May 2013 and December 2015 were selected as the AMI group, 45 patients with stable angina pectoris who were treated during the same period were selected as the SAP group, and 60 healthy volunteers who received physical examination during the same period were selected as the control group. Serum was collected to determine the levels of MR-proANP, neurohumor-related hormones and myocardial remodeling-related molecules. Results:Serum MR-proANP, NE, E, PRA, Ang-II, ALD, MMP2, MMP10, PICP and PIIINP levels of AMI group were significantly higher than those of SAP group and control group;serum NE, E, PRA, Ang-II, ALD, MMP2, MMP10, PICP and PIIINP levels in AMI group of patients with high MR-proANP levels were significantly higher than those in AMI group of patients with low MR-proANP levels.Conclusions:Serum MR-proANP significantly increases in patients with AMI and is closely related to the degree of compensatory neurohumoral change and myocardial remodeling.