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Alignment of human aquaporin 4 andß-amyloid proteins may indicate involvement ofß-amyloid in brain water homeostasis and prevention of brain edema
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作者 Steven Lehrer Peter H.Rheinstein 《Chronic Diseases and Translational Medicine》 CAS CSCD 2023年第2期177-181,共5页
The amyloid hypothesis states that the buildup ofßamyloid in the brain is the main factor for Alzheimer's disease(AD)pathogenesis.An imbalance betweenßamyloid production andß-amyloid clearance cause... The amyloid hypothesis states that the buildup ofßamyloid in the brain is the main factor for Alzheimer's disease(AD)pathogenesis.An imbalance betweenßamyloid production andß-amyloid clearance causes the advanced stages of the disease,including the development of neurofibrillary tangles containing tau protein. 展开更多
关键词 ALIGNMENT BRAIN EDEMA protein
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Shingles vaccination reduces the risk of Parkinson's disease
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作者 Steven Lehrer Peter H.Rheinstein 《Chronic Diseases and Translational Medicine》 CSCD 2023年第1期54-57,共4页
The most prevalent age-related movement condition,Parkinson's disease(PD),is characterized by bradykinesia,resting tremor,unbalanced gait,muscular rigidity,postural instability,as well as some nonmotor symptoms li... The most prevalent age-related movement condition,Parkinson's disease(PD),is characterized by bradykinesia,resting tremor,unbalanced gait,muscular rigidity,postural instability,as well as some nonmotor symptoms like autonomic and cognitive dysfunctions. 展开更多
关键词 herpes zoster Parkinson's disease SHINGLES VACCINE
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Alignment of human KAT2A(GCN5)histone acetyltransferase and SARS-CoV-2 Orf8 viral proteins
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作者 Steven Lehrer Peter H.Rheinstein 《Chronic Diseases and Translational Medicine》 CAS CSCD 2023年第3期263-265,共3页
The coronavirus SARS-CoV-2 has already claimed the lives of more than six million people,according to the World Health Organization,and the actual death toll may exceed 18 million.People are avoiding severe cases of C... The coronavirus SARS-CoV-2 has already claimed the lives of more than six million people,according to the World Health Organization,and the actual death toll may exceed 18 million.People are avoiding severe cases of COvID-19 thanks to vaccines,medications,and immunity from prior infections.Yet the virus's capacity to block the body's immune response,made possible by its arsenal of proteins,is one factor in its propensity to spread. 展开更多
关键词 ALIGNMENT PROTEIN VIRUS
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Association of cannabis with chronic obstructive pulmonary disease and COVID-19 infection
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作者 Steven Lehrer Peter H.Rheinstein 《Chronic Diseases and Translational Medicine》 CSCD 2022年第3期238-241,共4页
In a 2012 study,occasional and low cumulative cannabis use was not associated with adverse effects on pulmonary function.'With tobacco,the more used,the more loss of air flow rate and lung volume.The same was not ... In a 2012 study,occasional and low cumulative cannabis use was not associated with adverse effects on pulmonary function.'With tobacco,the more used,the more loss of air flow rate and lung volume.The same was not true with cannabis use.Air flow rate increased rather than decreased with increased exposure to cannabis up to a certain level. 展开更多
关键词 CANNABIS COPD COVID-19 lungs TOBACCO
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