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The photometric system of the One-meter Telescope at Weihai Observatory of Shandong University 被引量:6
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作者 Shao-Ming Hu Sheng-Hao Han +1 位作者 Di-Fu Guo Jun-Ju Du 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2014年第6期719-732,共14页
The one-meter telescope at Weihai Observatory (WHO) of Shandong University is an f/8 Cassegrain telescope. Three sets of filters are installed in a dual layer filterwheel that use Johnson-Cousins UBVRI, Sloan Digita... The one-meter telescope at Weihai Observatory (WHO) of Shandong University is an f/8 Cassegrain telescope. Three sets of filters are installed in a dual layer filterwheel that use Johnson-Cousins UBVRI, Sloan Digital Sky Survey u′g′r′i′z′ and Stomgren uvby. The photometric system and the CCD camera are introduced, followed by detailed analysis of their performances, and determination of the relevant parameters, including gain, readout noise, dark current and linearity of the CCD cam- era. In addition, the parameters describing the site's astro-climate, including typical seeing, statistics on the number of clear nights and average sky brightness, based on data gathered from Sep. 2007 to Aug. 2013, are systematically studied and reported in this work. Photometric calibrations were done using Landolt standard star obser- vations spanning eight nights, which yielded transformation coefficients, photometric precision and system throughput. The limiting magnitudes are simulated using the derived calibration parameters and classic observation conditions at WHO. 展开更多
关键词 telescopes -- site testing --instrumentation: miscellaneous - tech-niques: photometric
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An Empirical Study of Host Social Media on the Intercultural Adaptation of Preparatory International Students in China: A Case Study of Shandong University
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作者 XIE Na 《Cultural and Religious Studies》 2019年第2期99-109,共11页
This thesis probes into the current situation of host social media usage and intercultural adaptation of preparatory international students in China. Study covered 208 preparatory international students in total was c... This thesis probes into the current situation of host social media usage and intercultural adaptation of preparatory international students in China. Study covered 208 preparatory international students in total was conducted, with subject observation, structured interview, and questionnaire, in Shandong University, which is considered as one of the most representative institutions providing high-level preparatory education for international students in China. Field data collected were analyzed descriptively in the form of frequencies, tables, and percentages. Taken all that have been analyzed in this thesis, findings strongly suggest that the main factors influencing international students’ intercultural adaptability include host social media usage, intercultural experience, mandarin level, and cultural distance. Results also indicate significant correlation between host social media usage and intercultural adaptation: students who frequently use host social media to chat with Chinese perform better at intercultural adaptation;those who are more dependent and satisfied with host social media are more adaptive as well, the same goes to students who use host social media more frequently to get information or socialize. Consequently, this study suggests necessary promotion of host social media for international students in China. 展开更多
关键词 PREPARATORY international students HOST SOCIAL media INTERCULTURAL adaptation empirical study
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Special Issue on the 120th Anniversary of Shandong University
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作者 Haohai Yu Xiangang Xu +2 位作者 Zhanggui Hu Jiyang Wang Yicheng Wu 《Light(Science & Applications)》 SCIE EI CSCD 2023年第6期953-954,共2页
This special issue is committed to celebrating the 120th Anniversary of Shandong University(SDU)(15th October,2021),as well as capturing the most fascinating research works and reviews from all aspects of optics and p... This special issue is committed to celebrating the 120th Anniversary of Shandong University(SDU)(15th October,2021),as well as capturing the most fascinating research works and reviews from all aspects of optics and photonics,including but not limited to,optoelectronic functional crystals,basic science,applied and engineering research and applications. 展开更多
关键词 SHANDONG OPTICS COMMITTED
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Sedimentary Characteristics,Ages,and Environmental Significance of Gravel Deposits and Loess in Shandong,Eastern China:Regional Response to Global Change Since the Last Glacial Period
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作者 WANG Min KONG Fanbiao +6 位作者 KONG Xianglun CHEN Haitao WANG Jiawei MIAO Xiaodong JIA Guangju HAN Mei XU Shujian 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第2期491-504,共14页
Investigation of rarely studied gravel layers found in the loess in Shandong Province,eastern China,reveals the fabric characteristics of two gravel layers(G1,G2)and the sedimentary characteristics of loess at the typ... Investigation of rarely studied gravel layers found in the loess in Shandong Province,eastern China,reveals the fabric characteristics of two gravel layers(G1,G2)and the sedimentary characteristics of loess at the typical and well-preserved Heiyu section(HY),where,to determine the paleoclimatic changes during Marine Isotope Stage 3a.Optically stimulated luminescence dates of the HY formation range from 0.26±0.02 ka to 39.00±2.00 ka.In addition,the ages of G1 and G2 were estimated using the Bayesian model to be 39.60-40.50 and 29.00-29.50 ka.G1 and G2 are mainly composed of fine and medium gravel,both of which were subangular to subrounded limestone,with gravel directions to NE and E.The average flow velocity,average depth,and flood peak flow of G1 are 1.10 m/s,0.49 m,and 37.04 m^(3)/s,respectively,calculated using the flow energy method,whereas those of G2 are 0.98 m/s,0.38 m,and 18.38 m^(3)/s,respectively.Analysis of climate proxy indices show that the sedimentary environment of the gravel and loess in HY might be a regional response to global change. 展开更多
关键词 PALEOENVIRONMENT GEOCHRONOLOGY gravel layer SEDIMENTOLOGY PLEISTOCENE Shandong Province
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Magmatic-hydrothermal Evolution and Mineralization Mechanisms of the Wangjiazhuang Cu(-Mo)Deposit in the Zouping Volcanic Basin,Shandong Province,China:Constraints from Fluid Inclusions
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作者 SHU Lei YANG Renchao +5 位作者 SHEN Kun YANG Deping MAO Guangzhou LI Min LIU Pengrui MA Xiaodong 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第3期679-700,共22页
The Wangjiazhuang Cu(-Mo)deposit,located within the Zouping volcanic basin in western Shandong Province,China,is unique in this area for having an economic value.In order to expound the metallogenetic characteristics ... The Wangjiazhuang Cu(-Mo)deposit,located within the Zouping volcanic basin in western Shandong Province,China,is unique in this area for having an economic value.In order to expound the metallogenetic characteristics of this porphyry-like hydrothermal deposit,a detailed fluid inclusion study has been conducted,employing the techniques of representative sampling,fluid inclusion petrography,microthermometry,Raman spectroscopy,LA-ICP-MS analysis of single fluid inclusions,as well as cathode fluorescence spectrometer analysis of host mineral quartz.The deposit contains mainly two types of orebodies,i.e.veinlet-dissemination-stockwork orebodies in the K-Si alteration zone and pegmatiticquartz sulfide veins above them.In addition,minor breccia ore occurs locally.Four types of fluid inclusions in the deposit and altered quartz monzonite are identified:L-type one-or two-phase aqueous inclusions,V-type vapor-rich inclusions with V/L ratios greater than 50%-90%,D-type multiphase fluid inclusions containing daughter minerals or solids and S-type silicate-bearing fluid inclusions containing mainly muscovite and biotite.Ore petrography and fluid inclusion study has revealed a three-stage mineralization process,driven by magmatic-hydrothermal fluid activity,as follows.Initially,a hydrothermal fluid,separated from the parent magma,infiltrated into the quartz monzonite,resulting in its extensive K-Si alteration,as indicated by silicate-bearing fluid inclusions trapped in altered quartz monzonite.This is followed by the early mineralization,the formation of quartz veinlets and dissemination-stockwork ores.During the main mineralization stage,due to the participation and mixing of meteoric groundwater with magmatic-sourced hydrothermal fluid,the cooling and phase separation caused deposition of metals from the hydrothermal fluids.As a result,the pegmatitic-quartz sulfide-vein ores formed.In the late mineralization stage,decreasing fluid salinity led to the formation of L-type aqueous inclusions and chalcopyrite-sulfosalt ore.Coexistence of V-type and D-type inclusions and their similar homogenization temperatures with different homogenization modes suggest that phase separation or boiling of the ore-forming fluids took place during the early and the main mineralization stages.The formation P-T conditions of S-type inclusions and the early and the main mineralization stages were estimated as ca.156-182 MPa and 450-650℃,350-450℃,18-35 MPa and 280-380℃,8-15 MPa,respectively,based on the microthermometric data of the fluid inclusions formed at the individual stages. 展开更多
关键词 fluid inclusions fluid immiscibility mineralization mechanisms Wangjiazhuang Cu(-Mo)deposit
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Spatiotemporal Characteristics of Droughts and Floods in Shandong Province,China and Their Relationship with Food Loss 被引量:1
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作者 YANG Wentong ZHANG Liyuan YANG Ziyu 《Chinese Geographical Science》 SCIE CSCD 2023年第2期304-319,共16页
Mastering the pattern of food loss caused by droughts and floods aids in planning the layout of agricultural production,determining the scale of drought and flood control projects,and reducing food loss.The Standardiz... Mastering the pattern of food loss caused by droughts and floods aids in planning the layout of agricultural production,determining the scale of drought and flood control projects,and reducing food loss.The Standardized Precipitation Evapotranspiration Index is calculated using monthly meteorological data from 1984 to 2020 in Shandong Province of China and is used to identify the province’s drought and flood characteristics.Then,food losses due to droughts and floods are estimated separately from disaster loss data.Finally,the relationship between drought/flood-related factors and food losses is quantified using methods such as the Pearson correlation coefficient and linear regression.The results show that:1)there is a trend of aridity in Shandong Province,and the drought characteristic variables are increasing yearly while flood duration and severity are decreasing.2)The food losses caused by droughts in Shandong Province are more than those caused by floods,and the area where droughts and floods occur frequently is located in Linyi City.3)The impact of precipitation on food loss due to drought/flood is significant,followed by potential evapotranspiration and temperature.4)The relationship between drought and flood conditions and food losses can be precisely quantified.The accumulated drought duration of one month led to 1.939×10^(4)t of grain loss,and an increase in cumulative flood duration of one month resulted in1.134×10^(4)t of grain loss.If the cumulative drought severity and average drought peak increased by one unit,food loss due to drought will increase by 1.562×10^(4)t and 1.511×10^(6)t,respectively.If the cumulative flood severity and average flood peak increase by one unit,food loss will increase by 8.470×103t and 1.034×10^(6)t,respectively. 展开更多
关键词 drought disaster flood disaster food loss Pearson correlation Standardized Precipitation Evapotranspiration Index SHANDONG China
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Phylogenetic and epidemiological characteristics of H9N2 avian influenza viruses in Shandong Province, China from 2019 to 2021 被引量:1
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作者 ZHAO Yi-ran ZHAO Yu-zhong +7 位作者 LIU Si-dang XIAO Yi-hong LI Ning LIU Kui-hao MENG Fan-liang ZHAO Jun LIU Meng-da LI Bao-quan 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2023年第3期881-896,共16页
H9N2 avian influenza virus(AIV) has widely circulated in poultry worldwide and sporadic infections in humans and mammals. During our surveillance of chicken from 2019 to 2021 in Shandong Province, China, we isolated 1... H9N2 avian influenza virus(AIV) has widely circulated in poultry worldwide and sporadic infections in humans and mammals. During our surveillance of chicken from 2019 to 2021 in Shandong Province, China, we isolated 11 H9N2AIVs. Phylogenetic analyses showed that the eight gene segments of the 11 isolates were closely related to several sublineages of Eurasian lineage: BJ/94-like clades(HA and NA genes), G1-like clades(PB2 and M genes), and SH/F/98-like clades(PB1, PA, NP and NS genes). The isolates showed mutation sites that preferentially bind to humanlike receptors(HA) and mammalian fitness sites(PB2, PB1 and PA), as well as mutations in antigen and drug resistance sites. Moreover, studies with mice revealed four isolates with varying levels of pathogenicity. The average antibody titer of the H9N2 AIVs was 8.60 log2. Based on our results, the epidemiological surveillance of H9N2 AIVs should be strengthened. 展开更多
关键词 influenza virus phylogenetic analyses mutation sites PATHOGENICITY antibody titer epidemiological surveillance
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Expert Consensus by Qilu Hospital of Shandong University on the diagnosis,management,and treatment of suspected COVID-19 cases(English version)
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作者 Yuguo Chen 《Emergency and Critical Care Medicine》 2021年第1期6-11,共6页
We devised a protocol to establish a standardized method of screening,diagnosing,and managing suspected cases of coronavirus disease(COVID-19)and to enhance the management of COVID-19 suspected cases.The protocol that... We devised a protocol to establish a standardized method of screening,diagnosing,and managing suspected cases of coronavirus disease(COVID-19)and to enhance the management of COVID-19 suspected cases.The protocol that included diagnostic criteria,preventive measures,and control measures against COVID-19 was developed based on new evidence regarding the epidemiological and clinical characteristics of COVID-19.A consensus document was subsequently formulated.The consensus focused on the clinical management of patients with suspected fever and reviewed the procedure for undergoing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid testing.This consensus will contribute to the ongoing efforts worldwide for the prevention and control of COVID-19. 展开更多
关键词 COVID-19 Nucleic acid testing Suspected cases
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“一带一路”制造业增加值贸易网络对中国企业对外直接投资的影响研究 被引量:3
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作者 方慧 张潇叶 赵胜立 《南开经济研究》 北大核心 2024年第4期212-232,共21页
全球价值链重构趋势下,“一带一路”贸易网络日益紧密,东道国贸易网络地位对对外直接投资(OFDI)的影响逐渐显现,成为吸引中国企业“走出去”的新区位优势。本文基于“一带一路”共建国家制造业的投入产出数据构建增加值贸易网络,结合200... 全球价值链重构趋势下,“一带一路”贸易网络日益紧密,东道国贸易网络地位对对外直接投资(OFDI)的影响逐渐显现,成为吸引中国企业“走出去”的新区位优势。本文基于“一带一路”共建国家制造业的投入产出数据构建增加值贸易网络,结合2009—2019年A股上市公司、BvD-Zephyr以及fDi Markets数据,考察东道国贸易网络地位对中国企业OFDI的影响。研究发现:“一带一路”东道国制造业增加值贸易网络地位的提升,对中国企业OFDI具有显著的促进作用,且上述影响在发达国家、制度风险较低及开设境外园区的东道国更强,并且进一步激发了中国民营企业、初始投资企业“走出去”开展跨国并购的积极性。此外,中国企业OFDI的结构得以优化,投资行业依托贸易网络呈现阶梯状分布。机制分析表明,中间品进口激励效应、投资风险规避效应和全球价值链嵌入效应是其重要传导渠道。本文为中国企业面向“一带一路”共建国家的投资策略制定提供有益参考,对推动共建“一带一路”高质量发展具有重要现实意义。 展开更多
关键词 “一带一路” 增加值贸易网络 制造业 对外直接投资
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Spatial Agglomeration and Diffusion of Population Based on a Regional Density Function Approach:A Case Study of Shandong Province in China
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作者 Xiaohan Zhao Yanbin Chen 《Journal of Geographical Research》 2023年第3期61-80,共20页
Population density functions have long been used to describe the spatial structure of regional population distributions.Several studies have been conducted to examine the population distribution in Shandong Province,C... Population density functions have long been used to describe the spatial structure of regional population distributions.Several studies have been conducted to examine the population distribution in Shandong Province,China,but few have applied regional density functions to the analysis.Therefore,based on the 2000,2010,and 2020 population censuses,this study used monocentric and polycentric regional density functions to study the characteristics of population agglomeration and diffusion in Shandong.This is followed by an in-depth discussion based on population growth rate data and hot-and cold-spot analyses.The results showed that the Shandong Province population was spatially unevenly distributed.Population growth rates were higher in urban centers and counties,with more significant changes in population size in the eastern coastal areas than in the inland areas.As verified in this study,the logarithmic form of the single-center regional density function R2 was greater than 0.8,which was in line with the population spatial structure of Shandong Province.During the study period,the estimated population density of the regional center and the absolute value of the regional population density gradient both increased,indicating a clear and increasing trend of centripetal agglomeration of regional centers over the study period.Overall,the R2 value of the multicenter region density function was higher than that of the single-center region density function.The polycentric regional density function showed that the population density gradient of some centers had a downward trend,which reflected the spatial development trend of outward diffusion in these centers.Meanwhile,the variation in the estimated population density and the population density gradient exhibited differences in the central population distribution patterns at different levels. 展开更多
关键词 Regional density functions Population spatial structure Shandong Province
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“觉民行道”与“安民行道”——王阳明的“亲民”思想与当代中国的民生之道
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作者 钱明 Wang Keyou(译) 《孔学堂》 2024年第1期70-89,178-189,共32页
王阳明思想资源中与社会治理、民生政策关系最为密切的是他的“万物一体之仁”说与“亲民”说。阳明“亲民”说不仅表现在他的经典解释和义理观念上,更体现在他的政治实践和治理模式上,具有很强的功能性和可操作性,而且还与阳明学说在... 王阳明思想资源中与社会治理、民生政策关系最为密切的是他的“万物一体之仁”说与“亲民”说。阳明“亲民”说不仅表现在他的经典解释和义理观念上,更体现在他的政治实践和治理模式上,具有很强的功能性和可操作性,而且还与阳明学说在实用价值上所体现的公共性、平等性、安全性、效验性等要素相策应。“亲民”说还体现了从“觉民行道”到“安民行道”的重心转移上。而从“新民”“觉民”到“亲民”“安民”的跨越,乃是宋明时期出现的儒学民间化、庶民化的必然选择和必由之路。阳明心学的进一步平民化,不仅使之在义理上更加简易化,在属性上更加平等化,而且也是其“亲民”说由“觉民行道”走向“安民行道”、由偏重“教”和“觉”走向偏重“养”和“安”的重要前提。 展开更多
关键词 亲民 定位 诠释 属性 觉民行道 安民行道
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Protective mechanism of Coprinus comatus polysaccharide on acute alcoholic liver injury in mice,the metabolomics and gut microbiota investigation 被引量:3
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作者 Jinyan Yu Jianguang Sun +4 位作者 Min Sun Weidong Li Dongmei Qi Yongqing Zhang Chunchao Han 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期401-413,共13页
Coprinus comatus polysaccharide(CCP)has significant hepatoprotective effect.To explore hepatoprotective mechanism of CCP,the study analyzed preventive effect of CCP on acute alcoholic liver injury in mice by histopath... Coprinus comatus polysaccharide(CCP)has significant hepatoprotective effect.To explore hepatoprotective mechanism of CCP,the study analyzed preventive effect of CCP on acute alcoholic liver injury in mice by histopathological examination and biochemical analysis.Simultaneously,hepatoprotective mechanism was also analyzed in conjunction with metabolomics and proliferation of gut microbiota.The results showed that CCP significantly decreased alanine aminotransferase(ALT),aspartate aminotransferase(AST)and triglyceride(TG)levels in serum of alcoholic liver disease(ALD)mice.Histopathological examination showed that CCP can significantly improve liver damage.Metabolomics results showed that there were significant differences in the level of metabolites in liver tissue of control group,ALD group and CCP group,including taurine,xanthosine,fumaric acid and arachidonic acid,among others.Metabolites pathways analysis showed that hepatoprotective effect of CCP was related to energy metabolism,biosynthesis of unsaturated fatty acids,amino acids metabolism and lipid metabolism.Additionally,CCP inhibited an increase in the number of Clostridium perfringens,Enterobacteriaceae and Enterococcus,and a decrease in the number of Lactobacillus and Bifidobacterium in the gut of ALD mice.All these findings suggested that CCP treatment reversed the phenotype of ethanol-induced liver injury and the associated metabolites pathways. 展开更多
关键词 Coprinus comatus POLYSACCHARIDE Alcoholic liver disease Metabolomics Gut microbiota
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Advantages of nanocarriers for basic research in the field of traumatic brain injury 被引量:2
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作者 Xingshuang Song Yizhi Zhang +1 位作者 Ziyan Tang Lina Du 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第2期237-245,共9页
A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researche... A major challenge for the efficient treatment of traumatic brain injury is the need for therapeutic molecules to cross the blood-brain barrier to enter and accumulate in brain tissue.To overcome this problem,researchers have begun to focus on nanocarriers and other brain-targeting drug delivery systems.In this review,we summarize the epidemiology,basic pathophysiology,current clinical treatment,the establishment of models,and the evaluation indicators that are commonly used for traumatic brain injury.We also report the current status of traumatic brain injury when treated with nanocarriers such as liposomes and vesicles.Nanocarriers can overcome a variety of key biological barriers,improve drug bioavailability,increase intracellular penetration and retention time,achieve drug enrichment,control drug release,and achieve brain-targeting drug delivery.However,the application of nanocarriers remains in the basic research stage and has yet to be fully translated to the clinic. 展开更多
关键词 blood-brain barriers brain targeting central nervous system extracellular vesicles inflammatory factor microglial cell NANOCARRIERS nanoparticles neural restoration traumatic brain injury
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Nitrogen‑Doped Magnetic‑Dielectric‑Carbon Aerogel for High‑Efficiency Electromagnetic Wave Absorption 被引量:2
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作者 Shijie Wang Xue Zhang +5 位作者 Shuyan Hao Jing Qiao Zhou Wang Lili Wu Jiurong Liu Fenglong Wang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期313-327,共15页
Carbonbased aerogels derived from biomass chitosan are encountering a flourishing moment in electromagnetic protection on account of lightweight,controllable fabrication and versatility.Nevertheless,developing a facil... Carbonbased aerogels derived from biomass chitosan are encountering a flourishing moment in electromagnetic protection on account of lightweight,controllable fabrication and versatility.Nevertheless,developing a facile construction method of component design with carbon-based aerogels for high-efficiency electromagnetic wave absorption(EWA)materials with a broad effective absorption bandwidth(EAB)and strong absorption yet hits some snags.Herein,the nitrogen-doped magnetic-dielectric-carbon aerogel was obtained via ice template method followed by carbonization treatment,homogeneous and abundant nickel(Ni)and manganese oxide(MnO)particles in situ grew on the carbon aerogels.Thanks to the optimization of impedance matching of dielectric/magnetic components to carbon aerogels,the nitrogen-doped magnetic-dielectric-carbon aerogel(Ni/MnO-CA)suggests a praiseworthy EWA performance,with an ultra-wide EAB of 7.36 GHz and a minimum reflection loss(RLmin)of−64.09 dB,while achieving a specific reflection loss of−253.32 dB mm−1.Furthermore,the aerogel reveals excellent radar stealth,infrared stealth,and thermal management capabilities.Hence,the high-performance,easy fabricated and multifunctional nickel/manganese oxide/carbon aerogels have broad application aspects for electromagnetic protection,electronic devices and aerospace. 展开更多
关键词 Electromagnetic wave absorption Wide bandwidth Dielectric-magnetic synergy MULTIFUNCTION
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The miR-9-5p/CXCL11 pathway is a key target of hydrogen sulfide-mediated inhibition of neuroinflammation in hypoxic ischemic brain injury 被引量:2
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作者 Yijing Zhao Tong Li +6 位作者 Zige Jiang Chengcheng Gai Shuwen Yu Danqing Xin Tingting Li Dexiang Liu Zhen Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第5期1084-1091,共8页
We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation r... We previously showed that hydrogen sulfide(H2S)has a neuroprotective effect in the context of hypoxic ischemic brain injury in neonatal mice.However,the precise mechanism underlying the role of H2S in this situation remains unclear.In this study,we used a neonatal mouse model of hypoxic ischemic brain injury and a lipopolysaccharide-stimulated BV2 cell model and found that treatment with L-cysteine,a H2S precursor,attenuated the cerebral infarction and cerebral atrophy induced by hypoxia and ischemia and increased the expression of miR-9-5p and cystathionineβsynthase(a major H2S synthetase in the brain)in the prefrontal cortex.We also found that an miR-9-5p inhibitor blocked the expression of cystathionineβsynthase in the prefrontal cortex in mice with brain injury caused by hypoxia and ischemia.Furthermore,miR-9-5p overexpression increased cystathionine-β-synthase and H2S expression in the injured prefrontal cortex of mice with hypoxic ischemic brain injury.L-cysteine decreased the expression of CXCL11,an miR-9-5p target gene,in the prefrontal cortex of the mouse model and in lipopolysaccharide-stimulated BV-2 cells and increased the levels of proinflammatory cytokines BNIP3,FSTL1,SOCS2 and SOCS5,while treatment with an miR-9-5p inhibitor reversed these changes.These findings suggest that H2S can reduce neuroinflammation in a neonatal mouse model of hypoxic ischemic brain injury through regulating the miR-9-5p/CXCL11 axis and restoringβ-synthase expression,thereby playing a role in reducing neuroinflammation in hypoxic ischemic brain injury. 展开更多
关键词 chemokine(C-X-C motif)ligand 11 cystathionineβsynthase H2S hypoxic ischemic brain injury inflammation L-CYSTEINE lipopolysaccharide microglia miR-9-5p neuroprotection
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Drilling-based measuring method for the c-φ parameter of rock and its field application 被引量:3
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作者 Bei Jiang Fenglin Ma +5 位作者 Qi Wang Hongke Gao Dahu Zhai Yusong Deng Chuanjie Xu Liangdi Yao 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期65-76,共12页
The technology of drilling tests makes it possible to obtain the strength parameter of rock accurately in situ. In this paper, a new rock cutting analysis model that considers the influence of the rock crushing zone(R... The technology of drilling tests makes it possible to obtain the strength parameter of rock accurately in situ. In this paper, a new rock cutting analysis model that considers the influence of the rock crushing zone(RCZ) is built. The formula for an ultimate cutting force is established based on the limit equilibrium principle. The relationship between digital drilling parameters(DDP) and the c-φ parameter(DDP-cφ formula, where c refers to the cohesion and φ refers to the internal friction angle) is derived, and the response of drilling parameters and cutting ratio to the strength parameters is analyzed. The drillingbased measuring method for the c-φ parameter of rock is constructed. The laboratory verification test is then completed, and the difference in results between the drilling test and the compression test is less than 6%. On this basis, in-situ rock drilling tests in a traffic tunnel and a coal mine roadway are carried out, and the strength parameters of the surrounding rock are effectively tested. The average difference ratio of the results is less than 11%, which verifies the effectiveness of the proposed method for obtaining the strength parameters based on digital drilling. This study provides methodological support for field testing of rock strength parameters. 展开更多
关键词 Digital drilling Rock crushing zone c-u parameter Measurement method Field application
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Global,regional and national burdens of bipolar disorders in adolescents and young adults:a trend analysis from 1990 to 2019 被引量:2
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作者 Yunxi Zhong Yifan Chen +4 位作者 Xiaoying Su Meiqi Wang Qixiu Li Ziming Shao Long Sun 《General Psychiatry》 CSCD 2024年第1期122-132,共11页
Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young adults.Aims The aim of this study is to ascertain the trends in the b... Background Bipolar disorder is identified as a cause of severe damage to the physical,psychological and social functioning of adolescents and young adults.Aims The aim of this study is to ascertain the trends in the burden of bipolar disorder among individuals aged 10-24 years at global,regional and national levels from 1990 to 2019.Methods The data analysed in this study were from the Global Burden of Diseases 2019.The numbers,rates per 100000 population,average annual percentage changes(AAPCs)of incidence,prevalence and years lived with disability(YLDs)of bipolar disorder are reported at the global,regional and national levels among individuals aged 10-24 years.Global trends by age,sex and Social Development Index(SDI)were further analysed.Results Globally,the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100000 population(95%uncertainty interval(Ul):58.13 to 105.15)in 1990 to 84.97 per 100000 population(95%Ul:61.73 to 113.46)in 2019,AAPC 0.24(95%confidence interval(Cl):0.22 to 0.26).In the past three decades,there has been an increase in incidence,prevalence and YLDs in both males and females.The largest increase in incidence between 1990 and 2019 was observed in those aged 20-24 years old from 51.76 per 100000 population(95%Ul:26.81 to 87.20)in 1990 to 58.37 per 100000 population(95%UI:30.39 to 98.55)in 2019;AAPC 0.42(95%Cl:0.38 to 0.47).By the SDI quintile,the largest increase in incidence was observed in the middle SDl;however,the high SDI countries had the highest incidence.Regionally,the largest increase in incidence was observed in southern Latin America.At the national level,the most pronounced increase in the incidence was in Greenland.Conclusions The global increase in incidence among adolescents and young adults between 1990 and 2019 indicates that strategies to improve their mental health still need to be emphasised. 展开更多
关键词 ADOLESCENT BIPOLAR YOUNG
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Human umbilical cord mesenchymal stem cell-derived exosomes loaded into a composite conduit promote functional recovery after peripheral nerve injury in rats 被引量:1
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作者 Haoshuai Tang Junjin Li +6 位作者 Hongda Wang Jie Ren Han Ding Jun Shang Min Wang Zhijian Wei Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期900-907,共8页
Complete transverse injury of peripheral nerves is challenging to treat.Exosomes secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regu... Complete transverse injury of peripheral nerves is challenging to treat.Exosomes secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regulate tissue regeneration.In previous studies,a collagen/hyaluronic acid sponge was shown to provide a suitable regeneration environment for Schwann cell proliferation and to promote axonal regeneration.This three-dimensional(3D)composite conduit contains a collagen/hyaluronic acid inner sponge enclosed in an electrospun hollow poly(lactic-co-glycolic acid)tube.However,whether there is a synergy between the 3D composite conduit and exosomes in the repair of peripheral nerve injury remains unknown.In this study,we tested a comprehensive strategy for repairing long-gap(10 mm)peripheral nerve injury that combined the 3D composite conduit with human umbilical cord mesenchymal stem cell-derived exosomes.Repair effectiveness was evaluated by sciatic functional index,sciatic nerve compound muscle action potential recording,recovery of muscle mass,measuring the cross-sectional area of the muscle fiber,Masson trichrome staining,and transmission electron microscopy of the regenerated nerve in rats.The results showed that transplantation of the 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes promoted peripheral nerve regeneration and restoration of motor function,similar to autograft transplantation.More CD31-positive endothelial cells were observed in the regenerated nerve after transplantation of the loaded conduit than after transplantation of the conduit without exosomes,which may have contributed to the observed increase in axon regeneration and distal nerve reconnection.Therefore,the use of a 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes represents a promising cell-free therapeutic option for the treatment of peripheral nerve injury. 展开更多
关键词 axon growth collagen EXOSOME human umbilical cord mesenchymal stem cells hyaluronic acid muscular atrophy nerve guidance conduits peripheral nerve regeneration
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Manipulating Na occupation and constructing protective film of P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2) as long-term cycle stability cathode for sodium-ion batteries 被引量:1
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作者 Yiran Sun Pengfei Zhou +7 位作者 Siyu Liu Zhongjun Zhao Yihao Pan Xiangyan Shen Xiaozhong Wu Jinping Zhao Junying Weng Jin Zhou 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第1期603-611,I0013,共10页
P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)(NNMO)is promising cathode material for sodium-ion batteries(SIBs)due to its high specific capacity and fast Na+diffusion rate.Nonetheless,the irreversible P2-O_(2)phase transformati... P2-Na_(0.67)Ni_(0.33)Mn_(0.67)O_(2)(NNMO)is promising cathode material for sodium-ion batteries(SIBs)due to its high specific capacity and fast Na+diffusion rate.Nonetheless,the irreversible P2-O_(2)phase transformation,Na+/vacancy ordering,and transition metal(TM)dissolution seriously damage its cycling stability and restrict its commercialization process.Herein,Na occupation manipulation and interface stabilization are proposed to strengthen the phase structure of NNMO by synergistic Zn/Ti co-doping and introducing lithium difluorophosp(LiPO_(2)F_(2))film-forming electrolyte additive.The Zn/Ti co-doping regulates the occupancy ratio of Nae/Nafat Na sites and disorganizes the Na+/vacancy ordering,resulting in a faster Na+diffusion kinetics and reversible P2-Z phase transition for P2-Na_(0.67)Ni_(0.28)Zn_(0.05)Mn_(0.62)Ti_(0.05)O_(2)(NNZMTO).Meanwhile,the LiPO_(2)F_(2)additive can form homogeneous and ultrathin cathode-electrolyte interphase(CEI)on NNZMTO surface,which can stabilize the NNZMTO-electrolyte interface to prevent TM dissolution,surface structure transformation,and micro-crack generation.Combination studies of in situ and ex situ characterizations and theoretical calculations were used to elucidate the storage mechanism of NNZMTO with Li PO_(2)F_(2)additive.As a result,the NNZMTO displays outstanding capacity retention of 94.44%after 500 cycles at 1C with 0.3 wt%Li PO_(2)F_(2),excellent rate performance of 92.5 mA h g^(-1)at 8C with 0.1 wt%Li PO_(2)F_(2),and remarkable full cell capability.This work highlights the important role of manipulating Na occupation and constructing protective film in the design of layered materials,which provides a promising direction for developing high-performance cathodes for SIBs. 展开更多
关键词 Layered cathode Zn/Ti co-doping Na occupation Electrolyte additive Sodium-ion batteries
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An improved particle filter indoor fusion positioning approach based on Wi-Fi/PDR/geomagnetic field 被引量:1
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作者 Tianfa Wang Litao Han +5 位作者 Qiaoli Kong Zeyu Li Changsong Li Jingwei Han Qi Bai Yanfei Chen 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期443-458,共16页
The existing indoor fusion positioning methods based on Pedestrian Dead Reckoning(PDR)and geomagnetic technology have the problems of large initial position error,low sensor accuracy,and geomagnetic mismatch.In this s... The existing indoor fusion positioning methods based on Pedestrian Dead Reckoning(PDR)and geomagnetic technology have the problems of large initial position error,low sensor accuracy,and geomagnetic mismatch.In this study,a novel indoor fusion positioning approach based on the improved particle filter algorithm by geomagnetic iterative matching is proposed,where Wi-Fi,PDR,and geomagnetic signals are integrated to improve indoor positioning performances.One important contribution is that geomagnetic iterative matching is firstly proposed based on the particle filter algorithm.During the positioning process,an iterative window and a constraint window are introduced to limit the particle generation range and the geomagnetic matching range respectively.The position is corrected several times based on geomagnetic iterative matching in the location correction stage when the pedestrian movement is detected,which made up for the shortage of only one time of geomagnetic correction in the existing particle filter algorithm.In addition,this study also proposes a real-time step detection algorithm based on multi-threshold constraints to judge whether pedestrians are moving,which satisfies the real-time requirement of our fusion positioning approach.Through experimental verification,the average positioning accuracy of the proposed approach reaches 1.59 m,which improves 33.2%compared with the existing particle filter fusion positioning algorithms. 展开更多
关键词 Fusion positioning Particle filter Geomagnetic iterative matching Iterative window Constraint window
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