Totally implantable access ports(TIAPs)are used for patients with poor peripheral vascular support requiring central venous access.In recent years,TIAPs have been gradually accepted and promoted by patients,doctors,an...Totally implantable access ports(TIAPs)are used for patients with poor peripheral vascular support requiring central venous access.In recent years,TIAPs have been gradually accepted and promoted by patients,doctors,and nurses owing to their advantages of convenient carrying,a long maintenance period,low complications,and a high quality of life for patients.Currently,medical personnel that handle TIAP implantation and management in China are from different areas of healthcare,including surgery,internal medicine,radiology,nurse anesthesia,vascular access,etc.,and many only handle TIAP as a part of their duties.Therefore,the operating procedures and steps for the diagnosis and treatment of complications of TIAP vary from person to person,resulting in different incidence and treatment methods for complications in the implantation and use of TIAP in different medical units.Based on this,we have updated the Shanghai expert consensus on TIAPs from 2015 and explored the diagnosis and treatment procedures of related complications while continuing to emphasize standardized implantation and maintenance.展开更多
Inspired by the demand of improving the riding comfort and meeting the lightweight design of the vehicle, an inerter-based X-structure nonlinear energy sink(IXNES) is proposed and applied in the half-vehicle system to...Inspired by the demand of improving the riding comfort and meeting the lightweight design of the vehicle, an inerter-based X-structure nonlinear energy sink(IXNES) is proposed and applied in the half-vehicle system to enhance the dynamic performance. The X-structure is used as a mechanism to realize the nonlinear stiffness characteristic of the NES, which can realize the flexibility, adjustability, high efficiency, and easy operation of nonlinear stiffness, and is convenient to apply in the vehicle suspension, and the inerter is applied to replacing the mass of the NES based on the mass amplification characteristic. The dynamic model of the half-vehicle system coupled with the IX-NES is established with the Lagrange theory, and the harmonic balance method(HBM) and the pseudo-arc-length method(PALM) are used to obtain the dynamic response under road harmonic excitation. The corresponding dynamic performance under road harmonic and random excitation is evaluated by six performance indices, and compared with that of the original half-vehicle system to show the benefits of the IX-NES. Furthermore, the structural parameters of the IX-NES are optimized with the genetic algorithm. The results show that for road harmonic and random excitation, using the IX-NES can greatly reduce the resonance peaks and root mean square(RMS) values of the front and rear suspension deflections and the front and rear dynamic tire loads, while the resonance peaks and RMS values of the vehicle body vertical and pitching accelerations are slightly larger.When the structural parameters of the IX-NES are optimized, the vehicle body vertical and pitching accelerations of the half-vehicle system could reduce by 2.41% and 1.16%,respectively, and the other dynamic performance indices are within the reasonable ranges.Thus, the IX-NES combines the advantages of the inerter, X-structure, and NES, which improves the dynamic performance of the half-vehicle system and provides an effective option for vibration attenuation in the vehicle engineering.展开更多
Future inter-satellite clock comparison on high orbit will require optical time and frequency transmission technology between moving objects.Here,we demonstrate robust optical frequency transmission under the conditio...Future inter-satellite clock comparison on high orbit will require optical time and frequency transmission technology between moving objects.Here,we demonstrate robust optical frequency transmission under the condition of variable link distance.This variable link is accomplished by the relative motion of a single telescope fixed on the experimental platform to a corner-cube reflector(CCR)installed on a sliding guide.Two acousto–optic modulators with different frequencies are used to separate forward signal from backward signal.With active phase noise suppression,when the CCR moves back and forth at a constant velocity of 20 cm/s and an acceleration of 20 cm/s^(2),we achieve the best frequency stability of 1.9×10^(-16) at 1 s and 7.9×10^(-19) at 1000 s indoors.This work paves the way for future studying optical frequency transfer between ultra-high-orbit satellites.展开更多
Recently,the glymphatic system has been recognised as an important‘waste solutes transport channel’within the brain.1 Studies have shown that blockage of the glymphatic system leads to increased beta-amyloid deposit...Recently,the glymphatic system has been recognised as an important‘waste solutes transport channel’within the brain.1 Studies have shown that blockage of the glymphatic system leads to increased beta-amyloid deposits,accelerating the onset and progression of Alzheimer’s disease(AD).12 Given that cervical lymph nodes receive cerebrospinal fluid from the brain’s glymphatic system,34 we speculated that decompression of the lymphatic trunk and cervical lymphatic-venous anastomosis(LVA)could facilitate the flow of cerebrospinal fluid in the cranial glymphatic system,potentially accelerating the clearance of harmful beta-amyloid and tau proteins.We collaborated with surgeons who specialise in LVA supermicrosurgery for maxillofacial tumours and lymphoedema to develop a procedure to relieve the blockage of the glymphatic system.This surgery employs supermicrosurgery techniques to create LVA connecting the bilateral cervical,deep lymphatic vessels to the veins,resulting in lymphatic trunk decompression,which allows the lymph fluid in the high-pressure lymphatic vessels to flow into the low-pressure venous system.The goal of the minimally invasive surgery is to enhance the removal of proteins,such as beta-amyloid and tau,from the brain’s lymphatic systems to the maxillofacial lymphatic vessels,unclogging protein blockages within the brain.This extracranial procedure is safer than intracranial approaches.展开更多
Airborne bacteria play key roles in terrestrial and marine ecosystems and human health,yet our understanding of bacterial communities and their response to the environmental variables lags significantly behind that of...Airborne bacteria play key roles in terrestrial and marine ecosystems and human health,yet our understanding of bacterial communities and their response to the environmental variables lags significantly behind that of other components of PM_(2.5).Here,atmospheric fine particles obtained from urban and suburb Shanghai were analyzed by using the qPCR and Illumina Miseq sequencing.The bacteria with an average concentration of 2.12× 10^(3 )cells/m^(3),were dominated by Sphingomonas,Curvibacter,Acinetobacter,Bradyrhizobium,Methylobacterium,Halomonas,Aliihoeflea,and Phyllobacterium,which were related to the nitrogen,carbon,sulfur cycling and human health risk.Our results provide a global survey of bacterial community across urban,suburb,and high-altitude sites.In Shanghai(China),urban PM2.5 harbour more diverse and dynamic bacterial populations than that in the suburb.The structural equation model explained about 27%,41%,and 20%^78%of the variance found in bacteria diversity,concentration,and discrepant genera among urban and suburb sites.This work furthered the knowledge of diverse bacteria in a coastal Megacity in the Yangtze river delta and emphasized the potential impact of environmental variables on bacterial community structure.展开更多
OBJECTIVE: To characterize the tongue and pulse manifestations in asymptomatic coronavirus disease 2019(COVID-19) cases in Shanghai. METHODS: We conducted a clinical study of 668 patients with asymptomatic infections ...OBJECTIVE: To characterize the tongue and pulse manifestations in asymptomatic coronavirus disease 2019(COVID-19) cases in Shanghai. METHODS: We conducted a clinical study of 668 patients with asymptomatic infections in which we analyzed the tongue and pulse features in the Shanghai New International Expo Center mobile cabin hospital. The medical records of the patients, including tongue color, tongue coating, and pulse manifestations, were reviewed by healthcare workers. RESULTS: In total, 668 COVID-19 cases were included in the study. Patient age ranged from 5 to 96 years, with a median of 44.0(IQR 33.0-53.0) years. Among the patients, 6.14% had comorbidities. The most common comorbid condition was diabetes(1.65%), followed by hypertension(0.89%), coronary heart disease(0.89%), thrombotic diseases(0.89%), congestive heart failure(0.60%), and stroke(0.45%). Pink-red(75.4%) was the most common tongue color, followed by red(23.4%) and pale red(1.2%). Tongue coating color and thickness were classified as white fur(9.28%), thin and yellow fur(48.65%), white greasy fur(8.98%), yellow greasy fur(24.70%), and less coating(8.39%). In addition, a large number of patients(n = 300, 44.91%) presented superficial and rapid pulses, and 250 patients(37.4%) exhibited a slippery pulse. CONCLUSION: Our preliminary results showed that wind, heat, and dampness were the main etiologies of the severe acute respiratory syndrome coronavirus 2 Omicron(B.1.1.529) variant infection in traditional Chinese medicine. Furthermore, the main symptoms of the disease may be wind-heat invading the lung syndrome or damp-heat with the exuberance of virulence syndrome, which is of most significance in COVID-19 treatment.展开更多
Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal waters.However,the seasonal change of metal fluxes derived through SGD is unclear.Here,we evaluated the behaviours and fluxes o...Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal waters.However,the seasonal change of metal fluxes derived through SGD is unclear.Here,we evaluated the behaviours and fluxes of trace metals(Mn,Fe,Ba,Pb,U,Cr,Zn,Cu)in an estuary under different seasonal conditions.The behaviours of trace metals revealed that SGD was the source of Mn(3.51 mmol/(m^(2)·d)),Fe(0.174 mmol/(m^(2)·d))and Ba(0.024 mmol/(m^(2)·d)),but the Cu sink(−0.55μmol/(m^(2)·d))and other metals exhibited a seasonal source‒sink conversion.The seasonal variation of dissolved organic matter and the fresh groundwater proportion in subterranean estuaries may have an important effect on metals fluxes especially for the Fe,Mn and Ba.Our result shows that the single seasonal metal fluxes estimation applied to the annual scale will cause a large deviation,up to 3.6 times for Fe,5.5 times for Mn,and 15 times for Ba.Therefore,the influence of seasonal fluctuations on SGDderived metal fluxes cannot be ignored,and our findings will be important for comprehending the metal budget and cycle in nearshore environment.展开更多
From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectr...From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectrum,photometry and other information of each QSO will be visually checked carefully.Special attention should be paid to check whether there are groups of galaxies,gravitationally lensed arcs,Einstein crosses,or Einstein rings near the QSOs.Through careful selection,we select LAMOST J160603.01+290050.8(A)and LAMOST J160602.81+290048.7(B)as a candidate and perform an initial analysis.Components A and B are336 apart and they display blue during photometric observations.The redshift values of components A and B are0.2%different,their Gaia_g values are 1.3%different,and their ugriz values are 1.0%or less different.For the spectra covering from 3690 to 9100?,the emission lines of C II,Mg,Hγ,OⅢ,and Hβare present for both components A and B and the ratio of flux(B)to flux(A)from LAMOST is basically a constant,around 2.2.However,no galaxies have been found between components A and B.Inada et al.identified them as binary quasars.But we accidentally find a galaxy group near components A and B.If the center of dark matter in the galaxy group is at the center between components A and B,components A and B are probably gravitationally lensed QSOs.We estimate that the Einstein mass is 1.46×10^(11)M_⊙and the total mass of the lens is1.34×10^(13)M_⊙.The deflection angle is 197 at positions A and B and the velocity dispersion is 261 km s^(-1).Theoretically,this candidate could be a pair of fold images of a strong lensing system by a galaxy group,and we will investigate the possibility when the redshifts of nearby galaxies are available.展开更多
Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypo...Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD.Aims This study aimed to determine whether subjects with IGD have lower synaptic density than control subjects and the relationship between synaptic density and IGD severity.Methods Eighteen unmedicated subjects diagnosed with current IGD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria and 16 demographically matched healthy controls(HCs)participated in the study and underwent 18F-labelled difluoro-analogue of UCB-J(18F-SynVesT-1)positron emission tomography scans to assess the density of synaptic vesicle glycoprotein 2A(SV2A).The Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Hamilton Rating Scale for Depression(HAMD),Hamilton Anxiety Rating Scale(HAMA),Barratt Impulsiveness Scale Version 11(BIS-11),Stroop Colour-Word Test(SCWT),stop-signal paradigms and N-back tasks were administered to all subjects.Results Patients with IGD had significantly higher scores on the IGDS9-SF,HAMD,HAMA and BIS-11 than HCs.HCs performed better on the two-back and SCWT tests as well as in terms of stop-signal reaction times(SSRTs)in the stop-signal paradigms than patients with IGD.Lower uptake was found in the bilateral putamen,right pregenual anterior cingulate cortex and Rolandic operculum of patients with IGD compared with HCs.Furthermore,in the IGD group,IGDS9-SF scores and daily gaming hours were negatively correlated with the standardised uptake value ratios of 18F-SynVesT-1 in the bilateral putamen.Longer SSRTs were significantly associated with lower SV2A density in the right pregenual anterior cingulate cortex and right Rolandic operculum.Conclusions The in vivo results in this study suggest that lower synaptic density contributes to the severity and impairments in inhibitory control of IGD.These findings may provide further incentive to evaluate interventions that restore synaptic transmission and plasticity to treat IGD.展开更多
文摘Totally implantable access ports(TIAPs)are used for patients with poor peripheral vascular support requiring central venous access.In recent years,TIAPs have been gradually accepted and promoted by patients,doctors,and nurses owing to their advantages of convenient carrying,a long maintenance period,low complications,and a high quality of life for patients.Currently,medical personnel that handle TIAP implantation and management in China are from different areas of healthcare,including surgery,internal medicine,radiology,nurse anesthesia,vascular access,etc.,and many only handle TIAP as a part of their duties.Therefore,the operating procedures and steps for the diagnosis and treatment of complications of TIAP vary from person to person,resulting in different incidence and treatment methods for complications in the implantation and use of TIAP in different medical units.Based on this,we have updated the Shanghai expert consensus on TIAPs from 2015 and explored the diagnosis and treatment procedures of related complications while continuing to emphasize standardized implantation and maintenance.
基金Project supported by the National Natural Science Foundation of China (Nos. 12172153 and51805216)the China Postdoctoral Science Foundation (No. 2023M731668)the Major Project of Basic Science (Natural Science) of the Jiangsu Higher Education Institutions of China(No. 22KJA410001)。
文摘Inspired by the demand of improving the riding comfort and meeting the lightweight design of the vehicle, an inerter-based X-structure nonlinear energy sink(IXNES) is proposed and applied in the half-vehicle system to enhance the dynamic performance. The X-structure is used as a mechanism to realize the nonlinear stiffness characteristic of the NES, which can realize the flexibility, adjustability, high efficiency, and easy operation of nonlinear stiffness, and is convenient to apply in the vehicle suspension, and the inerter is applied to replacing the mass of the NES based on the mass amplification characteristic. The dynamic model of the half-vehicle system coupled with the IX-NES is established with the Lagrange theory, and the harmonic balance method(HBM) and the pseudo-arc-length method(PALM) are used to obtain the dynamic response under road harmonic excitation. The corresponding dynamic performance under road harmonic and random excitation is evaluated by six performance indices, and compared with that of the original half-vehicle system to show the benefits of the IX-NES. Furthermore, the structural parameters of the IX-NES are optimized with the genetic algorithm. The results show that for road harmonic and random excitation, using the IX-NES can greatly reduce the resonance peaks and root mean square(RMS) values of the front and rear suspension deflections and the front and rear dynamic tire loads, while the resonance peaks and RMS values of the vehicle body vertical and pitching accelerations are slightly larger.When the structural parameters of the IX-NES are optimized, the vehicle body vertical and pitching accelerations of the half-vehicle system could reduce by 2.41% and 1.16%,respectively, and the other dynamic performance indices are within the reasonable ranges.Thus, the IX-NES combines the advantages of the inerter, X-structure, and NES, which improves the dynamic performance of the half-vehicle system and provides an effective option for vibration attenuation in the vehicle engineering.
基金Project supported by the National Key Research and Development Program of China(Grant No.2020YFB0408300)the National Natural Science Foundation of China(Grant No.62175246)+2 种基金the Natural Science Foundation of Shanghai,China(Grant No.22ZR1471100)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.YIPA2021244)the Innovation Program for Quantum Science and Technology(Grant No.2021ZD0300701).
文摘Future inter-satellite clock comparison on high orbit will require optical time and frequency transmission technology between moving objects.Here,we demonstrate robust optical frequency transmission under the condition of variable link distance.This variable link is accomplished by the relative motion of a single telescope fixed on the experimental platform to a corner-cube reflector(CCR)installed on a sliding guide.Two acousto–optic modulators with different frequencies are used to separate forward signal from backward signal.With active phase noise suppression,when the CCR moves back and forth at a constant velocity of 20 cm/s and an acceleration of 20 cm/s^(2),we achieve the best frequency stability of 1.9×10^(-16) at 1 s and 7.9×10^(-19) at 1000 s indoors.This work paves the way for future studying optical frequency transfer between ultra-high-orbit satellites.
基金supported by the National Key R&D Program of China(2023YFC36003200)Shanghai Mental Health Center investigator-initiated trial programme(2024-TX-001)+1 种基金Shanghai's Top Priority Research Center(2022ZZ01017)CAMS Innovation Fund for Medical Sciences(2019-12M-5-037).
文摘Recently,the glymphatic system has been recognised as an important‘waste solutes transport channel’within the brain.1 Studies have shown that blockage of the glymphatic system leads to increased beta-amyloid deposits,accelerating the onset and progression of Alzheimer’s disease(AD).12 Given that cervical lymph nodes receive cerebrospinal fluid from the brain’s glymphatic system,34 we speculated that decompression of the lymphatic trunk and cervical lymphatic-venous anastomosis(LVA)could facilitate the flow of cerebrospinal fluid in the cranial glymphatic system,potentially accelerating the clearance of harmful beta-amyloid and tau proteins.We collaborated with surgeons who specialise in LVA supermicrosurgery for maxillofacial tumours and lymphoedema to develop a procedure to relieve the blockage of the glymphatic system.This surgery employs supermicrosurgery techniques to create LVA connecting the bilateral cervical,deep lymphatic vessels to the veins,resulting in lymphatic trunk decompression,which allows the lymph fluid in the high-pressure lymphatic vessels to flow into the low-pressure venous system.The goal of the minimally invasive surgery is to enhance the removal of proteins,such as beta-amyloid and tau,from the brain’s lymphatic systems to the maxillofacial lymphatic vessels,unclogging protein blockages within the brain.This extracranial procedure is safer than intracranial approaches.
基金by the Shanghai Sailing Program(19YF1403200)National Natural Science Foundation of China(Grant Nos.21906023,91843301,91743202,21527814)+2 种基金Ministry of Science and Technology of China(No.2016YFC0202700)Marie Skto-dowska-Curie Actions(690958-MARSU-RISE-2015)China Postdoctoral Science Foundation(No.2018M640331).
文摘Airborne bacteria play key roles in terrestrial and marine ecosystems and human health,yet our understanding of bacterial communities and their response to the environmental variables lags significantly behind that of other components of PM_(2.5).Here,atmospheric fine particles obtained from urban and suburb Shanghai were analyzed by using the qPCR and Illumina Miseq sequencing.The bacteria with an average concentration of 2.12× 10^(3 )cells/m^(3),were dominated by Sphingomonas,Curvibacter,Acinetobacter,Bradyrhizobium,Methylobacterium,Halomonas,Aliihoeflea,and Phyllobacterium,which were related to the nitrogen,carbon,sulfur cycling and human health risk.Our results provide a global survey of bacterial community across urban,suburb,and high-altitude sites.In Shanghai(China),urban PM2.5 harbour more diverse and dynamic bacterial populations than that in the suburb.The structural equation model explained about 27%,41%,and 20%^78%of the variance found in bacteria diversity,concentration,and discrepant genera among urban and suburb sites.This work furthered the knowledge of diverse bacteria in a coastal Megacity in the Yangtze river delta and emphasized the potential impact of environmental variables on bacterial community structure.
基金Supported by National Key R&D Program of China (2018YFC1705900)State Administration of Traditional Chinese Medicine,Traditional Chinese Medicine on Prevention and Treatment of Novel Coronavirus Pneumonia Emergency and Special Project (2022ZYLCYJ05-4)Shanghai University of Traditional Chinese Medicine,Traditional Chinese Medicine on Prevention and Treatment of Novel Coronavirus Pneumonia Emergency and Special Project (2022YJ-03, 2022YJ-06)。
文摘OBJECTIVE: To characterize the tongue and pulse manifestations in asymptomatic coronavirus disease 2019(COVID-19) cases in Shanghai. METHODS: We conducted a clinical study of 668 patients with asymptomatic infections in which we analyzed the tongue and pulse features in the Shanghai New International Expo Center mobile cabin hospital. The medical records of the patients, including tongue color, tongue coating, and pulse manifestations, were reviewed by healthcare workers. RESULTS: In total, 668 COVID-19 cases were included in the study. Patient age ranged from 5 to 96 years, with a median of 44.0(IQR 33.0-53.0) years. Among the patients, 6.14% had comorbidities. The most common comorbid condition was diabetes(1.65%), followed by hypertension(0.89%), coronary heart disease(0.89%), thrombotic diseases(0.89%), congestive heart failure(0.60%), and stroke(0.45%). Pink-red(75.4%) was the most common tongue color, followed by red(23.4%) and pale red(1.2%). Tongue coating color and thickness were classified as white fur(9.28%), thin and yellow fur(48.65%), white greasy fur(8.98%), yellow greasy fur(24.70%), and less coating(8.39%). In addition, a large number of patients(n = 300, 44.91%) presented superficial and rapid pulses, and 250 patients(37.4%) exhibited a slippery pulse. CONCLUSION: Our preliminary results showed that wind, heat, and dampness were the main etiologies of the severe acute respiratory syndrome coronavirus 2 Omicron(B.1.1.529) variant infection in traditional Chinese medicine. Furthermore, the main symptoms of the disease may be wind-heat invading the lung syndrome or damp-heat with the exuberance of virulence syndrome, which is of most significance in COVID-19 treatment.
基金The National Key Research and Development Program of China under contract No.2018YFD0900702the National Natural Science Foundation of China under contract Nos 41976040,41976041 and 42006152.
文摘Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal waters.However,the seasonal change of metal fluxes derived through SGD is unclear.Here,we evaluated the behaviours and fluxes of trace metals(Mn,Fe,Ba,Pb,U,Cr,Zn,Cu)in an estuary under different seasonal conditions.The behaviours of trace metals revealed that SGD was the source of Mn(3.51 mmol/(m^(2)·d)),Fe(0.174 mmol/(m^(2)·d))and Ba(0.024 mmol/(m^(2)·d)),but the Cu sink(−0.55μmol/(m^(2)·d))and other metals exhibited a seasonal source‒sink conversion.The seasonal variation of dissolved organic matter and the fresh groundwater proportion in subterranean estuaries may have an important effect on metals fluxes especially for the Fe,Mn and Ba.Our result shows that the single seasonal metal fluxes estimation applied to the annual scale will cause a large deviation,up to 3.6 times for Fe,5.5 times for Mn,and 15 times for Ba.Therefore,the influence of seasonal fluctuations on SGDderived metal fluxes cannot be ignored,and our findings will be important for comprehending the metal budget and cycle in nearshore environment.
基金provided by the National Development and Reform Commissionthe support of the National Natural Science Foundation of China(NSFC,11803004)+2 种基金Yunnan Province Youth Talent Project(2019182)the support by NSFC through grant No.12203011Yunnan provincial Department of Science and Technology through grant No.202101BA070001-261。
文摘From 2011 to 2021,LAMOST has released a total of 76,167 quasar data.We try to search for gravitationally lensed QSOs by limiting coordinate differences and redshift differences of these QSOs.The name,brightness,spectrum,photometry and other information of each QSO will be visually checked carefully.Special attention should be paid to check whether there are groups of galaxies,gravitationally lensed arcs,Einstein crosses,or Einstein rings near the QSOs.Through careful selection,we select LAMOST J160603.01+290050.8(A)and LAMOST J160602.81+290048.7(B)as a candidate and perform an initial analysis.Components A and B are336 apart and they display blue during photometric observations.The redshift values of components A and B are0.2%different,their Gaia_g values are 1.3%different,and their ugriz values are 1.0%or less different.For the spectra covering from 3690 to 9100?,the emission lines of C II,Mg,Hγ,OⅢ,and Hβare present for both components A and B and the ratio of flux(B)to flux(A)from LAMOST is basically a constant,around 2.2.However,no galaxies have been found between components A and B.Inada et al.identified them as binary quasars.But we accidentally find a galaxy group near components A and B.If the center of dark matter in the galaxy group is at the center between components A and B,components A and B are probably gravitationally lensed QSOs.We estimate that the Einstein mass is 1.46×10^(11)M_⊙and the total mass of the lens is1.34×10^(13)M_⊙.The deflection angle is 197 at positions A and B and the velocity dispersion is 261 km s^(-1).Theoretically,this candidate could be a pair of fold images of a strong lensing system by a galaxy group,and we will investigate the possibility when the redshifts of nearby galaxies are available.
基金supported by the STI2030-Major Projects(grant number 2022ZD0211100,NZ)Foundation of Shanghai Mental Health Center(grant number 2021-YJ15,JL)+5 种基金National Natural Science Foundation of China(grant number 82272045,SH)National Natural Science Foundation of China(grant number 82201702,QX)Science and Technology Innovation Program of Hunan Province(grant number 2021RC4056,SH)Key Program of Ministry of Industry and Information Technology of China(grant number CEIEC-2022-ZM02-0219,SH)National Natural Science Foundation of China(grant number 82001405,HD)Hunan Natural Science Foundation Youth Program(grant number 2021JJ40979,HD).
文摘Background Internet gaming disorder(IGD)is an ideal model to study the mechanisms underlying synaptic deficits in addiction as it eliminates the confounding effects of substance use.Synaptic loss and deficits are hypothesised to underlie the enduring maladaptive behaviours and impaired cognitive function that contribute to IGD.Aims This study aimed to determine whether subjects with IGD have lower synaptic density than control subjects and the relationship between synaptic density and IGD severity.Methods Eighteen unmedicated subjects diagnosed with current IGD according to the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition criteria and 16 demographically matched healthy controls(HCs)participated in the study and underwent 18F-labelled difluoro-analogue of UCB-J(18F-SynVesT-1)positron emission tomography scans to assess the density of synaptic vesicle glycoprotein 2A(SV2A).The Internet Gaming Disorder Scale-Short Form(IGDS9-SF),Hamilton Rating Scale for Depression(HAMD),Hamilton Anxiety Rating Scale(HAMA),Barratt Impulsiveness Scale Version 11(BIS-11),Stroop Colour-Word Test(SCWT),stop-signal paradigms and N-back tasks were administered to all subjects.Results Patients with IGD had significantly higher scores on the IGDS9-SF,HAMD,HAMA and BIS-11 than HCs.HCs performed better on the two-back and SCWT tests as well as in terms of stop-signal reaction times(SSRTs)in the stop-signal paradigms than patients with IGD.Lower uptake was found in the bilateral putamen,right pregenual anterior cingulate cortex and Rolandic operculum of patients with IGD compared with HCs.Furthermore,in the IGD group,IGDS9-SF scores and daily gaming hours were negatively correlated with the standardised uptake value ratios of 18F-SynVesT-1 in the bilateral putamen.Longer SSRTs were significantly associated with lower SV2A density in the right pregenual anterior cingulate cortex and right Rolandic operculum.Conclusions The in vivo results in this study suggest that lower synaptic density contributes to the severity and impairments in inhibitory control of IGD.These findings may provide further incentive to evaluate interventions that restore synaptic transmission and plasticity to treat IGD.
