Dear Editor As one of the most important staple food crops worldwide, rice is among the first plant species whose genomes were sequenced. The reference genome for Oryza sativa ssp. japonica variety Nipponbare was comp...Dear Editor As one of the most important staple food crops worldwide, rice is among the first plant species whose genomes were sequenced. The reference genome for Oryza sativa ssp. japonica variety Nipponbare was completed by the International Rice Genome Sequencing Project （IRGSP） using a bacterial artificial chromosome （BAC）-based cloning strategy （Matsumoto et al., 2005）.展开更多
Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA.However,removing the methyl group from a modified cytosine is chemically difficult and therefore,the underlying mechanism of...Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA.However,removing the methyl group from a modified cytosine is chemically difficult and therefore,the underlying mechanism of demethylation had remained unclear for many years.The discovery of the first eukaryotic DNA demethylase,Arabidopsis thaliana REPRESSOR OF SILENCING 1(ROS1),led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation.In the 20 years since ROS1 was discovered,our understanding of this active DNA demethylation pathway,as well as its regulation and biological functions in plants,has greatly expanded.These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation,with potential applications in epigenome editing to facilitate crop breeding and gene therapy.展开更多
The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the pl...The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth.展开更多
基金This work is supported in part by grants from the National Key Basic Research Program in China （2013CB127005）, the National Natural Science Foundation of China （nos. 31401128, 31571310）, and the Ministry of Agriculture of China （2016ZX08010-002）, and by Special Fund for Strategic Pilot Technology Chinese Academy of Sciences （XDA08020104）.
文摘Dear Editor As one of the most important staple food crops worldwide, rice is among the first plant species whose genomes were sequenced. The reference genome for Oryza sativa ssp. japonica variety Nipponbare was completed by the International Rice Genome Sequencing Project （IRGSP） using a bacterial artificial chromosome （BAC）-based cloning strategy （Matsumoto et al., 2005）.
基金Excellent Young Scientist Fund of NSFC(Grant No.31922008)Strategic Priority Research Program of CAS(Grant No.XDB27040108)+1 种基金Shanghai Agriculture Applied Technology Development Program,China(Grant No.X20200101)the National Key R&D Program of China(2021YFA1300401)。
文摘Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA.However,removing the methyl group from a modified cytosine is chemically difficult and therefore,the underlying mechanism of demethylation had remained unclear for many years.The discovery of the first eukaryotic DNA demethylase,Arabidopsis thaliana REPRESSOR OF SILENCING 1(ROS1),led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation.In the 20 years since ROS1 was discovered,our understanding of this active DNA demethylation pathway,as well as its regulation and biological functions in plants,has greatly expanded.These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation,with potential applications in epigenome editing to facilitate crop breeding and gene therapy.
文摘The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth.
