Experimental Study on the Viscoelastic Behaviors of Debris Flow Slurry

The rheological properties of most liquid in nature are between liquids and solids,including both elastic changes and viscosity changes,that is socalled "viscoelastic".Dynamic oscillatory test was used to quantitatively study the distinct viscoelastic behaviors of debris flow slurry in the shear stress conditions for the first time in this study.The debris flow slurry samples were from Jiangjiagou Ravine,Yunnan Province,China.The experimental results were found that at the low and middle stages of shearing,when the angular velocity ω<72.46 s-1,the loss modulus(G") was greater than the storage modulus(G'),i.e.G">G'.At the late stage of shearing,when the angular velocity ω≧72.46 s-1,the storage modulus was greater than or equal to the loss modulus,i.e.G'≧G",tanδ≦1(where phase-shift angleδ=G"/G'),and the debris flow slurry was in a gel state.Therefore,the progress of this experimental study further reveals the mechanism of hyperconcentrated debris flows with a high velocity on low-gradient ravines.

The Likeliness of China Importing 100 Million MT of Soybean and Outlook of Palm Oil in 2018

Introduction Import of palm oil in China has witnessed a stagnating or rather downtrend in recent years after it climbed to its peak of 6.34 million MT in 2012. The import volume basically was hovering between 5.00 and 6.00 million MTafterthat,with exceptional of 2016 where import dropped below 4.50 million MT due to global shortage of CPO output (Figure 1). Many would ponder why palm oil being the most produced and price competitive vegetable oil was unable to increase its sales in the country that has huge population and strong growing economy?

Menopausal depression:comparison of hormone replacement therapy and hormone replacement therapy plus fluoxetine

BACKGROUND: To compare the efficacy and safety of hormone replacement therapy (HRT) combined with fluoxetine, with HRT alone, in post-menopausal women suffering from depression. METHODS: A randomized, open-label, parallel trial was applied. HRT was administered to all patients for 2 cycles, with 14 days of estrogen therapy and 14 days of estrogen plus progesterone. Patients who were randomly assigned to the HRT plus fluoxetine group were given fluoxetine in combination with HRT. Hamilton Depression Rating Scale (HAMD), Kupperman Menopausal Index (KMI), and Clinical Global Impressions scale were used to measure the efficacy. RESULTS: One hundred and twenty-three post-menopausal patients with depression were enrolled in the study. Among them, 120 had at least one post-treatment visit and entered into the statistical analysis. The mean total HAMD scores were significantly lower, and the percentages of HAMD score reductions were higher in the HRT plus fluoxetine Group compared with the HRT Group, after at least 3 weeks of treatment, with an average difference of 5 points at the endpoint. The Clinical Global Impression-Severity and Clinical Global Impression-Improvement scores were significantly different in the 2 groups, in favor of the combination therapy. The mean total KMI was significantly lower in the Combination Group compared with the HRT Group, after at least 6 weeks of treatment, with an average 4.5-point difference between the groups. No statistically significant differences were found in most of the adverse events reported in the Combination Group compared with the HRT group, with the exception of 3 symptoms, i.e., dry mouth, loss of appetite, and abdominal distention. They were mild to moderate in severity. Two patients in the HRT group, but none in the combination group, dropped out due to adverse events. CONCLUSION: HRT plus fluoxetine therapy was effective in the treatment of menopausal depression with a satisfactory safety profile.

A real-time and modular approach for quick detection and mechanism exploration of DPIs with different carrier particle sizes

Dry powder inhalers(DPIs) had been widely used in lung diseases on account of direct pulmonary delivery, good drug stability and satisfactory patient compliance. However, an indistinct understanding of pulmonary delivery processes(PDPs) hindered the development of DPIs. Most current evaluation methods explored the PDPs with over-simplified models, leading to uncompleted investigations of the whole or partial PDPs. In the present research, an innovative modular process analysis platform(MPAP) was applied to investigate the detailed mechanisms of each PDP of DPIs with different carrier particle sizes(CPS). The MPAP was composed of a laser particle size analyzer, an inhaler device,an artificial throat and a pre-separator, to investigate the fluidization and dispersion, transportation,detachment and deposition process of DPIs. The release profiles of drug, drug aggregation and carrier were monitored in real-time. The influence of CPS on PDPs and corresponding mechanisms were explored. The powder properties of the carriers were investigated by the optical profiler and Freeman Technology four powder rheometer. The next generation impactor was employed to explore the aerosolization performance of DPIs. The novel MPAP was successfully applied in exploring the comprehensive mechanism of PDPs, which had enormous potential to be used to investigate and develop DPIs.