Effect of anti-fibrosis compound on collagen expression of hepatic cells in experimental liver fibrosis of rats

INTRODUCTIONLiver fibrosis is mainly characterized by theexcessive synthesis and decreased degradation ofextracellular matrix(ECM),especially the synthesisand deposition of collagen.Almost all kinds of cellsin the liver have participated in the production ofcollagen.The most important ones are hepaticstellate cells(HSC)and hepatocytes.We

Correlation analysis between TCM syndrome types and laboratory indicators in initial pulmonary tuberculosis patients

Objective To observe the correlation between TCM syndromes types of initial pulmonary tuberculosis patients and laboratory examination indicators,thus providing objective evidence for combined diagnosis and treatment of disease identification and syndrome typing.

Differences in coagulation and fibrinolytic markers of different TCM syndromes in patients with chronic kidney disease

Objective To analyze the differences between coagulation and fibrinolysis biomarkers in different TCM syndromes of chronic kidney disease(CKD),and to explore the changes of these indicators in the progression of disease,as well as to provide references for clinical diagnosis and treatment of TCM.

Canagliflozin attenuates human podocyte injury through inhibiting reactive oxygen species/NOD-like receptor thermal protein domain associated protein 3 signaling pathway

Objective To investigate the efficacy and mechanism of canagliflozin (Cana) in the treatment of high glucoseinduced human podocyte (HPC) injury.Methods The HPCs were divided into 5 groups:normal glucose group(NG group),mannitol group(MA group),high glucose group(HG group),Cana low dose(0.3μmol/L) group and Cana high dose (1.0μmol/L) group.

Shuchang decoction for treatment of diarrhea predominant irritable bowel syndrome with Gan depression and Pi deficiency:a multicenter,randomized,double-blind,placebo controlled trial

Objective To observe the clinical efficacy and safety of Shuchang Decoction (SCD) in the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D)with Gan depression and Pi deficiency syndrome.Methods A total of 179 patients with IBS-D were recruited from 12 hospitals of Shanghai TCM Gastroenterology Federation.

Wangbi capsule for active rheumatoid arthritis:a multicenter,randomized,double-blind,parallel-controlled study

Objective To evaluate the efficacy and safety of Wangbi Capsule(WBC)in the treatment of active rheumatoid arthritis(RA).Methods Totally 101 patients in line with inclusion criteria from 114 patients with active RA were assigned to the treatment group(52 cases)and the control group(49 cases)by using block randomization method,which was stratified by center with a selected segment length of 2 and the PROC PLAN procedure statement in SAS9.4 Software used to give the number of seeds.Patients in the treatment group took WBC+methotrexate(MTX),while those in the control group took WBC placebo+MTX.The treatment course lasted for 12 weeks.By comparing the 28 joint disease activity scores(DAS28-ESR)based1onerythrocyte sedimentation rate(ESR),28 joint disease activity scores(DAS28-CRP)based onC-reactive protein(CRP),DAS28-ESR remission rate,DAS28-CRP remission rate,ESR,CRP,rheumatoid factor(RF),and anti-cyclic citrulline antibody(ACPA)before and after treatment,patient visual analogue score(VAS),physician VAS score,joint pain count,joint swelling count.

Yixin formula alleviates myocardial ischemia-reperfusion injury in rats via modulating SIRT1/Nrf2/HO-1 signaling pathway

Objective To explore the role and its mechanism of Yixin Formula (YXF) on myocardial ischemia-reperfusion injury (MIRI) in rats.Methods Totally 75 Wistar rats were divided into five groups randomly:Sham,IR,YXF+IR,YXF+IR+SIRT1-inhibitor(EX527),and YXF+IR+SIRT1-agonist (SRT1720)groups,15 in each group.

Study on distribution of Chinese medicine syndromes in children with non-severe aplastic anemia

Objective To explore the distribution of Chinese medicine (CM) syndromes of children with non-severe aplastic anemia (NSAA),and to provide reference for CM clinical sydrome differentiation and classification of NSAA.

Effect of Shugan Hewei formula on intestinal flora in treatment of refractory gastroesophageal reflux disease with Gan-Wei disharmony:a randomized controlled trial

Objective To evaluate the clinical efficacy and effect on intestinal flora of Shugan Hewei Formula(SGHWF) in the treatment of refractory gastroesophageal reflux disease (rGERD) with Gan-Wei disharmony syndrome.Methods Totally 80 rGERD patients with Gan-Wei disharmony were assigned to treatment group and control group by random number table,40 cases in each group.

Effect of acupuncture-moxibustion on negative emotions and plasma tryptophan metabolism in patients with Crohn’s disease at active stage

Objective To observe the effect of acupuncturemoxibustion on negative emotions and plasma tryptophan(Trip)-kynurenmne (Kyn) metabolism in patients with Crohn’s disease (CD) at the mild and moderate active stage.Methods A total of 66 CD patients were randomized into an observation group (33 cases,1 case dropped off) and a control group (33 cases, 2 cases dropped off).

The correlation between metabolic syndrome and benign prostatic hyperplasia and drug efficacy evaluation

Objective To explore the correlation between metabolic syndrome(MS)and benign prostatic hyperplasia(BPH)and the drug treatment of BPH.Methods 300cases of BPH patients treated between May 2011 to June2012 in our hospital and Tonghai County hospitals of traditonal Chinese medicine were included.The patients were divided into observing group(n=100)and

Clinical efficacy on xerosis conjunctivitis of liver and kidney yin deficiency treated with SHI's acupuncture manipulation

Objective To compare the efficacy of the patients of xerosis conjunctivitis with liver and kidney yin deficiency among the combined therapy of acupuncture and Shi’s manipulation,common acupuncture and artificial tears therapy.Methods One hundred and eight patients were randomized into an acupuncture group,a SHI’s manipulation group and an artificial tears group,36 cases in each group.A total of 15 cases dropped out before

Treatment of gouty arthritis in different phases by a series of Tongfeng granule: an efficacy observation

Objective To evaluate the clinical efficacy of a series of Tongfeng Granule(TG)in treating gouty arthritis patients in different stages.Methods Ninety primary gout patients were randomly assigned to two groups,the TCM treatment group(60 cases)and the Western medicine control group(30 cases).Huzhang Tongfeng Granule in combination with external application of Jinhuang Ointment was given to those in the TCM treatment group in the acute phase,and Yinlian Tongfeng Granule in

Efficacy impacts of the different treatment frequencies on female stress urinary incontinence

Objective To observe the effect on female stress urinary incontinence(SUI)treated with the pudendal nerve stimulation of electroacupuncture therapy at different frequencies.Methods Sixty patients were divided into a group treated three times every week(group A)and a group treated twice every week(group B),30 cases in each one.The pudendal nerve stimulation of electroacupuncture therapy was adopted at Disixue(four acupoints on sacral region),60 min in each time in the two groups。

Effect of Shengqing capsule on serum cholesterol content and hepatic scavenger receptor class B of rats with cholesterol calculus

Objective To observe the effect of Shengqing Capsule(SC)on serum contents of TC,LDL-C,and HDLC,hepatic scavenger receptor BⅠ(SRBⅠ),and CD36 in rats with cholesterol calculus.Methods

Effect of needle roller combined with Qiangli Yiqi prescription on the levels of inflammatory cytokine in myasthenia gravis with Pi-qi deficiency:a randomised controlled trial

Objective To observe the curative effect of needle roller combined with Qiangli Yiqi Prescription(QLYQP)on myasthenia gravis(MG)patients with Pi-qi deficiency and on the levels of inflammatory factors such as interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α).Methods A randomised controlled trial was conducted,and 72 patients with Pi-qi deficiency myasthenia gravis admitted to Shanghai Hospital of Integrated Traditional Chinese and Western Medicine from July 2018 to June 2020 were randomly assigned to treatment group and control group,with 36 in each group.

Clinical observation on electroacupuncture at"four points of sacral region"on moderate to severe stress urinary incontinence after radical prostatectomy

Objective To compare the clinical therapeutic effect between electroacupuncture at"four points of sacral region"and transurethral Erbium laser in treatment of moderate to severe stress urinary incontinence after radical prostatectomy.Methods A total of 68 patients of moderate to severe stress urinary incontinence after radical prostatectomy were divided into an electroacupuncture group(34 cases)and an Erbium laser group(34 cases,3 cases dropped off)according to the settings.

Efficacy and safety of Xinjia Danshen decoction combined with warfarin in the treatment of atrial fibrillation with blood stasis syndrome: a randomized controlled trial

Objective To explore the efficacy and safety of Xinjia Danshen Decoction combined with warfarin in treating atrial fibrillation with blood stasis syndrome.Methods Totally 64 patients with persistent atrial fibrillation with blood stasis syndrome who met the indications of anticoagulant therapy were randomly assigned into 2 groups.

Investigation of the influencing factors and Chinese medicine syndrome elements of mild cognitive impairment in diabetes mellitus

Objective To explore the influencing factors of mild cognitive impairment (MCI) in diabetes patients and the characteristics of Chinese medicine (CM) syndromes.Methods Totally 249 diabetic patients were divided into cognitive normal cognitive group (165 cases) and MCI group (84 cases).The incidence,age,educational level,course of disease,complications,drug use。

Effects of Yinang formula on serum metabonomics for chronic kidney disease stage 3-4 in patients with autosomal dominant polycystic kidney disease

Objective To study the effects of Yinang formula(YNF)on serum metabonomics for chronic kidney disease(CKD)stage 3-4 in patients with autosomal dominant polycystic kidney disease(ADPKD).Methods Thirty CKD 3-4 patients with ADPKD treated with YNF for 24 weeks were selected from October 2017 to March 2019 at Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.