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Analysis of papers published in Journal of Shanghai University(English Edition) from 1997 to 2004
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作者 陈爱萍 洪鸥 《Journal of Shanghai University(English Edition)》 CAS 2006年第6期563-566,共4页
Statistical analysis of various data for the papers published in Journal of Shanghai University ( English Edition) from 1997 to 2004 was made. The issues examined include numbers of published papers, disciplinary di... Statistical analysis of various data for the papers published in Journal of Shanghai University ( English Edition) from 1997 to 2004 was made. The issues examined include numbers of published papers, disciplinary distribution, constituents of authors, propor- tions of collaborated papers contributed by multiple authors and papers based on cooperation between different institutions, publishing retardation, and citation of references. Suggestions are made for further improving the quality of the Journal. 展开更多
关键词 Journal of Shanghai University (English Edition) statistical analysis quality of the Journal.
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Paper Analysis of Shanghai Ocean University in Bibliometric Method from Web of Science
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作者 Jia Jiang 《Journal of Applied Mathematics and Physics》 2024年第2期632-638,共7页
The data of this research was mainly collected from the Web of Science (WOS) and Incites database platform, which was filtered and cataloged according to the different platforms. For tracing the change in scientific r... The data of this research was mainly collected from the Web of Science (WOS) and Incites database platform, which was filtered and cataloged according to the different platforms. For tracing the change in scientific research at Shanghai Ocean University, make use of Bibliometric analysis to get the image and table of highly cited papers and hot papers. In this study, the scientific aspects in highly cited papers and hot papers, published in the last year in the core collection of Web of Science, were taken as objects, and office software was used as the main tool to carry out bibliometric and figure analysis. From the four aspects to find the difference in these fields, the production of specific fields and cited times is inconsistent. And suggest the department and management adjust the policy and method via elastic personnel and rewards to prompt the advancement of the research fields. 展开更多
关键词 Highly Cited Papers Hot Paper Shanghai Ocean University COMPARISON Cited Times AUTHOR
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Relationship between physical activity and specific working memory indicators of depressive symptoms in university students
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作者 Qun Zhao Xing Wang +6 位作者 Shu-Fan Li Peng Wang Xiang Wang Xin Xin Suo-Wang Yin Zhao-Song Yin Li-Juan Mao 《World Journal of Psychiatry》 SCIE 2024年第1期148-158,共11页
BACKGROUND The detection rate of depression among university students has been increasing in recent years,becoming one of the main psychological diseases that endangers their physical and mental health.According to st... BACKGROUND The detection rate of depression among university students has been increasing in recent years,becoming one of the main psychological diseases that endangers their physical and mental health.According to statistics,self-harm and suicide,for which there is no effective intervention,are the second leading causes of death.AIM To explore the relationship between different elements and levels of physical activity and college students’depression-symptom-specific working memory indicators.METHODS Of 143 college students were analyzed using the Beck Depression Self-Rating Scale,the Physical Activity Rating Scale,and the Working Memory Task.RESULTS There was a significant difference between college students with depressive symptoms and healthy college students in completing verbal and spatial working memory(SWM)tasks correctly(all P<0.01).Physical Activity Scale-3 scores were significantly and positively correlated with the correct rate of the verbal working memory task(r=0.166)and the correct rate of the SWM task(r=0.210)(all P<0.05).There were significant differences in the correct rates of verbal and SWM tasks according to different exercise intensities(all P<0.05)and different exercise durations(all P<0.05),and no significant differences in the correct rates of verbal and SWM tasks by exercise frequency(all P>0.05).CONCLUSION An increase in physical exercise among college students,particularly medium-and high-intensity exercise and exercise of 30 min or more,can improve the correct rate of completing working memory tasks. 展开更多
关键词 Physical activity Depression symptoms University students Working memory
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The Evolution of Mass Media and Shanghai-Style Suzhou Pingtan in Modern Shanghai
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作者 HONG Yu 《Journalism and Mass Communication》 2024年第4期215-226,共12页
With the development of urban culture in modern Shanghai,Shanghai style(海派Haipai)has gradually formed its own features.As a crucial component of urban culture,modern mass media reflects the essence of Shanghai-style... With the development of urban culture in modern Shanghai,Shanghai style(海派Haipai)has gradually formed its own features.As a crucial component of urban culture,modern mass media reflects the essence of Shanghai-style culture in its development.Its modernity,commerciality,openness,and innovation display the cultural trait of keeping up with the times.During the Xianfeng and Tongzhi periods of the Qing Dynasty(1851-1875),Suzhou Pingtan(苏州评弹)was introduced to Shanghai due to the influence of the Taiping Rebellion(太平天国战争),and began its Shanghai-style evolution in the context of modern mass media.On the one hand,modern newspapers and electronic media became crucial tools for the promotion of Suzhou Pingtan performers;on the other hand,the daily lives,performing careers,and public images of these performers became focal points of media attention.Mass media facilitated the Shanghai-style development of Suzhou Pingtan,and through it,changes in commercial awareness,performance styles,artistic expressions,musical innovation,and the celebrity-like performers all reflected the process of Shanghai-style development in Pingtan art. 展开更多
关键词 modern mass media Shanghai-style Suzhou Pingtan COMMERCIALIZATION process of becoming stars
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Increased Prevalence of Thyroid Nodules Across Nearly 10 Years in Shanghai,China 被引量:3
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作者 Meng-ying QU Wei TANG +6 位作者 Xue-ying CUI Yu-xiang JIN Zheng-yuan WANG Chang-yi GUO Xiao-dong JIA Yong-quan SHI Jia-jie ZANG 《Current Medical Science》 SCIE CAS 2023年第1期191-197,共7页
Objective This study aimed to determine whether the prevalence of thyroid nodules(TNs)increased due to modern lifestyles or other factors,despite the advances in screening and diagnostic tools.Methods This study inclu... Objective This study aimed to determine whether the prevalence of thyroid nodules(TNs)increased due to modern lifestyles or other factors,despite the advances in screening and diagnostic tools.Methods This study included 3474 pairs of participants,who were matched by gender and age(±3 years)from two cross-sectional sampling surveys:(1)the program on the iodine nutritional status and related health status of residents in Shanghai in 2009;(2)the thyroid disease screening program for adults in Shanghai between 2017 and 2018.The prevalence of TNs and thyroid diseases in 2009 and 2017–2018 were compared,and the potential risk factors of TNs were detected.Results The prevalence of TNs in 2009 was 28.9%:22.5%in males and 34.5%in females.In 2017,this increased to 43.8%:37.9%in males and 49.1%in females.The prevalence of TNs significantly increased from 2009 to 2017(odds ratio,1.486;95%confidence interval,1.238–1.786).In addition,female gender,thyroid disease history,and age were the main risk factors for TNs after adjusting for confounders in the logistic regression across the time period.Conclusion The prevalence of TNs significantly increased across nearly 10 years in Shanghai. 展开更多
关键词 thyroid nodules PREVALENCE period difference detection technology thyroid disease
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A MySQL-Based Software System of Urban Land Planning Database of Shanghai in China
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作者 Pei Yin Jing Cheng 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第6期2387-2405,共19页
With the development of the digital city,data and data analysis have become more and more important.The database is the foundation of data analysis.In this paper,the software system of the urban land planning database... With the development of the digital city,data and data analysis have become more and more important.The database is the foundation of data analysis.In this paper,the software system of the urban land planning database of Shanghai in China is developed based on MySQL.The conceptual model of the urban land planning database is proposed,and the entities,attributes and connections of this model are discussed.Then the E-R conceptual model is transformed into a logical structure,which is supported by the relational databasemanagement system(DBMS).Based on the conceptual and logical structures,by using Spring Boot as the back-end framework and using MySQL and Java API as the development tools,a platformwith datamanagement,information sharing,map assistance and other functions is established.The functionalmodules in this platformare designed.The results of J Meter test show that the DBMS can add,store and retrieve information data stably,and it has the advantages of fast response and low error rate.The software system of the urban land planning database developed in this paper can improve the efficiency of storing and managing land data,eliminating redundant data and sharing data. 展开更多
关键词 SOFTWARE DATABASE database management system urban land planning MYSQL
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Latest developments in EUV photoresist evaluation capability at Shanghai Synchrotron Radiation Facility
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作者 Zhen‑Jiang Li Cheng‑Hang Qi +8 位作者 Bei‑Ning Li Shu‑Min Yang Jun Zhao Zhi‑Di Lei Shi‑Jie Zhu Hao Shi Lu Wang Yan‑Qing Wu Ren‑Zhong Tai 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第12期206-215,共10页
Evaluating the comprehensive characteristics of extreme ultraviolet(EUV)photoresists is crucial for their application in EUV lithography,a key process in modern technology.This paper highlights the capabilities of the... Evaluating the comprehensive characteristics of extreme ultraviolet(EUV)photoresists is crucial for their application in EUV lithography,a key process in modern technology.This paper highlights the capabilities of the Shanghai Synchrotron Radiation Facility(SSRF)08U1B beamline in advancing this field.Specifically,it demonstrates how this beamline can create fringe patterns with a 15-nm half-pitch on a resist using synchrotron-based EUV lithography.This achievement is vital for evaluating EUV photoresists at the advanced 5-nm node.We provide a detailed introduction to the methods and experimental setup used at the SSRF 08U1B beamline to assess an EUV photoresist.A significant part of this research involved the fabrication of high-resolution hydrogen silsesquioxane mask gratings.These gratings,with an aspect ratio of approximately 3,were created using electron beam lithography on an innovative mask framework.This framework was crucial in eliminating the impact of zeroth-order light on interference patterns.The proposed framework propose offers a new approach to mask fabrication,particularly beneficial for achromatic Talbot lithography and multicoherent-beam interference applications. 展开更多
关键词 Extreme ultraviolet photoresist Interference lithography HIGH-RESOLUTION Electron beam lithography·Hydrogen silsesquioxane GRATING
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Genetic Diversity and Population Structure Analysis of Barley Landraces from Shanghai Region Using Genotyping-by-Sequencing
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作者 Luli Li Nigel G.Halford +5 位作者 Huihui Wang Yingjie Zong Zhenzhu Guo Ruiju Lu Chenghong Liu Zhiwei Chen 《Phyton-International Journal of Experimental Botany》 SCIE 2023年第4期1275-1287,共13页
Barley(Hordeum vulgare L.)is an important economic crop for food,feed and industrial raw materials.In the present research,112 barley landraces from the Shanghai region were genotyped using genotyping-by-sequencing(GB... Barley(Hordeum vulgare L.)is an important economic crop for food,feed and industrial raw materials.In the present research,112 barley landraces from the Shanghai region were genotyped using genotyping-by-sequencing(GBS),and the genetic diversity and population structure were analyzed.The results showed that 210,268 Single Nucleotide Polymorphisms(SNPs)were present in total,and the average poly-morphism information content(PIC)was 0.1642.Genetic diversity and population structure analyses suggested that these barley landraces were differentiated and could be divided into three sub-groups,with morphological traits of row-type and adherence of the hulls the main distinguishing factors between groups.Genotypes with similar or duplicated names were also investigated according to their genetic backgrounds and seed appearances.This study provided valuable information on barley landraces from the Shanghai region,and showed that all these barley landraces should be protected and used for future breeding programs. 展开更多
关键词 Hordeum vulgare L cluster analysis population structure SNP markers
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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression 被引量:3
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作者 Qiuqin Han Wenhui Li +5 位作者 Peiqing Chen Lijuan Wang Xiwen Bao Renyan Huang Guobin Liu Xiaorong Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1890-1898,共9页
Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containin... Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments. 展开更多
关键词 DEPRESSION MICROGLIA NEUROINFLAMMATION NLRP3 inflammasome
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社会企业组织混合性与社会影响力的关系研究 被引量:4
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作者 刘志阳 邱振宇 +1 位作者 许莉萍 庄欣荷 《南开管理评论》 北大核心 2024年第1期246-256,I0045,I0046,共13页
作为战略和组织研究前沿,混合组织在现实中表现出不同程度的组织混合性。但有关组织混合性及其表现迄今仍鲜有实证研究结论。本文以典型混合组织——社会企业作为研究对象,基于“认知—行为—结果”理论框架,系统研究了组织混合性与社... 作为战略和组织研究前沿,混合组织在现实中表现出不同程度的组织混合性。但有关组织混合性及其表现迄今仍鲜有实证研究结论。本文以典型混合组织——社会企业作为研究对象,基于“认知—行为—结果”理论框架,系统研究了组织混合性与社会影响力的内在关联,并从资源拼凑视角揭示了二者之间的行为“黑箱”。实证结果表明:(1)社会企业的高组织混合性有利于社会影响力的提升;(2)资源拼凑行为在组织混合性和社会影响力之间起中介作用;(3)数字化能力对资源拼凑行为的中介作用起正向调节作用。本研究深化了组织混合性及其结果的关系,明确了组织混合性在提高社会影响力方面的独特优势,也为数字时代下包括社会企业在内的混合组织发展提供了经验证据. 展开更多
关键词 组织混合性 社会影响力 社会企业 数字化能力 混合组织
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Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries 被引量:2
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作者 Jiayi Li Li Gao +7 位作者 Fengying Pan Cheng Gong Limeng Sun Hong Gao Jinqiang Zhang Yufei Zhao Guoxiu Wang Hao Liu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第1期187-221,共35页
Lithium–sulfur(Li–S)batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost.Nevertheless,the shuttle effect of firm multi-step two-elect... Lithium–sulfur(Li–S)batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost.Nevertheless,the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value.Many methods were proposed for inhibiting the shuttle effect of polysulfide,improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries.Here,we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries.First,the electrochemical principles/mechanism and origin of the shuttle effect are described in detail.Moreover,the efficient strategies,including boosting the sulfur conversion rate of sulfur,confining sulfur or lithium polysulfides(LPS)within cathode host,confining LPS in the shield layer,and preventing LPS from contacting the anode,will be discussed to suppress the shuttle effect.Then,recent advances in inhibition of shuttle effect in cathode,electrolyte,separator,and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries.Finally,we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries. 展开更多
关键词 Shuttle effect Designed strategies Li-S battery Lithium polysulfides
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Building Feedback-Regulation System Through Atomic Design for Highly Active SO_(2)Sensing 被引量:1
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作者 Xin Jia Panzhe Qiao +8 位作者 Xiaowu Wang Muyu Yan Yang Chen Bao-Li An Pengfei Hu Bo Lu Jing Xu Zhenggang Xue Jiaqiang Xu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第7期343-357,共15页
Reasonably constructing an atomic interface is pronouncedly essential for surface-related gas-sensing reaction.Herein,we present an ingen-ious feedback-regulation system by changing the interactional mode between sing... Reasonably constructing an atomic interface is pronouncedly essential for surface-related gas-sensing reaction.Herein,we present an ingen-ious feedback-regulation system by changing the interactional mode between single Pt atoms and adjacent S species for high-efficiency SO_(2)sensing.We found that the single Pt sites on the MoS_(2)surface can induce easier volatiliza-tion of adjacent S species to activate the whole inert S plane.Reversely,the activated S species can provide a feedback role in tailoring the antibonding-orbital electronic occupancy state of Pt atoms,thus creating a combined system involving S vacancy-assisted single Pt sites(Pt-Vs)to synergistically improve the adsorption ability of SO_(2)gas molecules.Further-more,in situ Raman,ex situ X-ray photoelectron spectroscopy testing and density functional theory analysis demonstrate the intact feedback-regulation system can expand the electron transfer path from single Pt sites to whole Pt-MoS_(2)supports in SO_(2)gas atmosphere.Equipped with wireless-sensing modules,the final Pt1-MoS_(2)-def sensors array can further realize real-time monitoring of SO_(2)levels and cloud-data storage for plant growth.Such a fundamental understanding of the intrinsic link between atomic interface and sensing mechanism is thus expected to broaden the rational design of highly effective gas sensors. 展开更多
关键词 Feedback-regulation system Atomic interface SO_(2)sensor Single-atom sensing mechanism Intelligent-sensing array
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Total flavonoids of Astragalus membranaceus protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in mice by inhibiting ferroptosis through SLC7A11/GPX-4 signaling pathway 被引量:1
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作者 Zitian Gao Gaorui Wang +6 位作者 Yujie Chen Wuke Yuan Jun Cai Aiping Feng Jie Fang Qi Xu Xiaojun Wu 《Food Science and Human Wellness》 SCIE CSCD 2024年第1期414-420,共7页
Parkinson’s disease(PD)is a common neurodegenerative disorder with no cure.Astragalus membranaceus is used in Chinese culture as a food supplement to boost immunity.The present study aimed to explore the neuroprotect... Parkinson’s disease(PD)is a common neurodegenerative disorder with no cure.Astragalus membranaceus is used in Chinese culture as a food supplement to boost immunity.The present study aimed to explore the neuroprotective effects of total flavonoids extracted from A.membranaceus(TFA)and their protective mechanisms.TFA offered neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)in the mouse model of Parkinsonism,by improving behavior performance in the gait analysis and pole test,and inhibiting the decline of tyrosine hydroxylase(TH)positive neurons and TH protein expression in substantia nigra of mice.TFA also prevented 1-methyl-4-phenylpyridinium(MPP+)induced neurotoxicity in SHSY5Y cells,by increasing GSH and GSH/GSSG ratio,and reducing reactive oxygen species.In addition,the neuroprotective effects of TFA were associated with its ability to restore MPTP/MPP+induced downregulation of SLC7A11 and glutathione peroxidase 4(GPX-4).In conclusion,we demonstrated that TFA exerted significant neuroprotection against MPTP/MPP+induced neurodegeneration by inhibiting ferroptosis through the regulation of SLC7A11/GPX-4 axis,suggesting the use of TFA as a possible food supplement in the prevention of PD. 展开更多
关键词 Parkinson’s disease Total fl avonoids of Astragalus membranaceus Ferroptosis SLC7A11
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Dynamics and vibration reduction performance of asymmetric tristable nonlinear energy sink 被引量:3
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作者 Hongyan CHEN Youcheng ZENG +2 位作者 Hu DING Siukai LAI Liqun CHEN 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2024年第3期389-406,共18页
With its complex nonlinear dynamic behavior,the tristable system has shown excellent performance in areas such as energy harvesting and vibration suppression,and has attracted a lot of attention.In this paper,an asymm... With its complex nonlinear dynamic behavior,the tristable system has shown excellent performance in areas such as energy harvesting and vibration suppression,and has attracted a lot of attention.In this paper,an asymmetric tristable design is proposed to improve the vibration suppression efficiency of nonlinear energy sinks(NESs)for the first time.The proposed asymmetric tristable NES(ATNES)is composed of a pair of oblique springs and a vertical spring.Then,the three stable states,symmetric and asymmetric,can be achieved by the adjustment of the distance and stiffness asymmetry of the oblique springs.The governing equations of a linear oscillator(LO)coupled with the ATNES are derived.The approximate analytical solution to the coupled system is obtained by the harmonic balance method(HBM)and verified numerically.The vibration suppression efficiency of three types of ATNES is compared.The results show that the asymmetric design can improve the efficiency of vibration reduction through comparing the chaotic motion of the NES oscillator between asymmetric steady states.In addition,compared with the symmetrical tristable NES(TNES),the ATNES can effectively control smaller structural vibrations.In other words,the ATNES can effectively solve the threshold problem of TNES failure to weak excitation.Therefore,this paper reveals the vibration reduction mechanism of the ATNES,and provides a pathway to expand the effective excitation amplitude range of the NES. 展开更多
关键词 ASYMMETRIC nonlinear energy sink(NES) tristable vibration control po-tential barrier
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Assessment of Dependent Performance Shaping Factors in SPAR-H Based on Pearson Correlation Coefficient 被引量:1
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作者 Xiaoyan Su Shuwen Shang +2 位作者 Zhihui Xu Hong Qian Xiaolei Pan 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第2期1813-1826,共14页
With the improvement of equipment reliability,human factors have become the most uncertain part in the system.The standardized Plant Analysis of Risk-Human Reliability Analysis(SPAR-H)method is a reliable method in th... With the improvement of equipment reliability,human factors have become the most uncertain part in the system.The standardized Plant Analysis of Risk-Human Reliability Analysis(SPAR-H)method is a reliable method in the field of human reliability analysis(HRA)to evaluate human reliability and assess risk in large complex systems.However,the classical SPAR-H method does not consider the dependencies among performance shaping factors(PSFs),whichmay cause overestimation or underestimation of the risk of the actual situation.To address this issue,this paper proposes a new method to deal with the dependencies among PSFs in SPAR-H based on the Pearson correlation coefficient.First,the dependence between every two PSFs is measured by the Pearson correlation coefficient.Second,the weights of the PSFs are obtained by considering the total dependence degree.Finally,PSFs’multipliers are modified based on the weights of corresponding PSFs,and then used in the calculating of human error probability(HEP).A case study is used to illustrate the procedure and effectiveness of the proposed method. 展开更多
关键词 Reliability evaluation human reliability analysis SPAR-H performance shaping factors DEPENDENCE pearson correlation analysis
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BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway 被引量:1
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作者 Jun-li ZHAO Lin ZHAO +3 位作者 Qiu-nan ZHAN Miao LIU Ting ZHANG Wen-wen CHU 《Current Medical Science》 SCIE CAS 2024年第2期333-345,共13页
Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investi... Objective:Peritoneal fibrosis(PF)is the main cause of declining efficiency and ultrafiltration failure of the peritoneum,which restricts the long-term application of peritoneal dialysis(PD).This study aimed to investigate the therapeutic effects and mechanisms of bone marrow mesenchymal stem cells-derived exosomes(BMSC-Exos)on PF in response to PD.Methods:Small RNA sequencing analysis of BMSC-Exos was performed by second-generation sequencing.C57BL/6J mice were infused with 4.25%glucose-based peritoneal dialysis fluid(PDF)for 6 consecutive weeks to establish a PF model.A total of 36 mice were randomly divided into 6 groups:control group,1.5%PDF group,2.5%PDF group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Reverse transcription quantitative polymerase chain reaction(RT-qPCR)was performed to measure the expression level of miR-27a-3p in BMSC-Exos and peritoneum of mice treated with different concentrations of PDF.HE and Masson staining were performed to evaluate the extent of PF.The therapeutic potential of BMSC-Exos for PF was examined through pathological examination,RT-qPCR,Western blotting,and peritoneal function analyses.Epithelial-mesenchymal transition(EMT)of HMrSV5 was induced with 4.25%PDF.Cells were divided into control group,4.25%PDF group,BMSC-Exos treatment group,and BMSC-Exos+TP53 treatment group.Cell Counting Kit-8 assay was used to measure cell viability,and transwell migration assay was used to verify the capacity of BMSC-Exos to inhibit EMT in HMrSV5 cells.Results:Small RNA sequencing analysis showed that miR-27a-3p was highly expressed in BMSC-derived exosomes compared to BMSCs.The RT-qPCR results showed that the expression of miR-27a-3p was upregulated in BMSC-Exos,but decreased in PD mice.We found that PF was glucose concentration-dependently enhanced in the peritoneum of the PD mice.Compared with the control mice,the PD mice showed high solute transport and decreased ultrafiltration volume as well as an obvious fibroproliferative response,with markedly increased peritoneal thickness and higher expression ofα-SMA,collagen-I,fibronectin,and ECM1.The mice with PD showed decreased miR-27a-3p.Peritoneal structural and functional damage was significantly attenuated after BMSC-Exos treatment,while PF and mesothelial damage were significantly ameliorated.Additionally,markers of fibrosis(α-SMA,collagen-I,fibronectin,ECM1)and profibrotic cytokines(TGF-β1,PDGF)were downregulated at the mRNA and protein levels after BMSC-Exos treatment.In HMrSV5 cells,BMSC-Exos reversed the decrease in cell viability and the increase in cell migratory capacity caused by high-glucose PDF.Western blotting and RT-qPCR analysis revealed that BMSC-Exos treatment resulted in increased expression of E-cadherin(epithelial marker)and decreased expression ofα-SMA,Snail,and vimentin(mesenchymal markers)compared to those of the 4.25%PDF-treated cells.Importantly,a dual-luciferase reporter assay showed that TP53 was a target gene of miR-27a-3p.TP53 overexpression significantly reversed the decreases in PF and EMT progression induced by BMSC-Exos.Conclusion:The present results demonstrate that BMSC-Exos showed an obvious protective effect on PD-related PF and suggest that BMSC-derived exosomal miR-27a-3p may exert its inhibitory effect on PF and EMT progression by targeting TP53. 展开更多
关键词 peritoneal fibrosis bone marrow mesenchymal stem cell-derived exosomes miR-27a-3p TP53 epithelialmesenchymal transition
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Stable Cycling of All-Solid-State Lithium Metal Batteries Enabled by Salt Engineering of PEO-Based Polymer Electrolytes 被引量:1
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作者 Lujuan Liu Tong Wang +6 位作者 Li Sun Tinglu Song Hao Yan Chunli Li Daobin Mu Jincheng Zheng Yang Dai 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期67-74,共8页
Poly(ethylene oxide)(PEO)-based polymer electrolytes show the prospect in all-solid-state lithium metal batteries;however,they present limitations of low room-temperature ionic conductivity,and interfacial incompatibi... Poly(ethylene oxide)(PEO)-based polymer electrolytes show the prospect in all-solid-state lithium metal batteries;however,they present limitations of low room-temperature ionic conductivity,and interfacial incompatibility with high voltage cathodes.Therefore,a salt engineering of 1,1,2,2,3,3-hexafluoropropane-1,3-disulfonimide lithium salt(LiHFDF)/LiTFSI system was developed in PEO-based electrolyte,demonstrating to effectively regulate Li ion transport and improve the interfacial stability under high voltage.We show,by manipulating the interaction between PEO matrix and TFSI^(-)-HFDF^(-),the optimized solid-state polymer electrolyte achieves maximum Li+conduction of 1.24×10^(-4)S cm^(-1)at 40℃,which is almost 3 times of the baseline.Also,the optimized polymer electrolyte demonstrates outstanding stable cycling in the LiFePO_(4)/Li and LiNi_(0.8)Mn_(0.1)Co_(0.1)O_(2)/Li(3.0-4.4 V,200 cycles)based all-solid-state lithium batteries at 40℃. 展开更多
关键词 all-solid-state battery high voltage li-ion conductivity molecular interaction poly(ethylene oxide)
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Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy 被引量:2
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作者 Hang Yu Mingting Shao +4 位作者 Xi Luo Chaoqin Pang Kwok-Fai So Jiandong Yu Li Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第3期657-662,共6页
Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its appl... Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain limited.Although regular exercise effectively improves learning and memory functions across multiple neurological diseases,its application in patients with epilepsy remains controversial.Here,we adopted a 14-day treadmill-exercise paradigm in a pilocarpine injection-induced mouse model of epilepsy.Cognitive assays confirmed the improvement of object and spatial memory after endurance training,and electrophysiological studies revealed the maintenance of hippocampal plasticity as a result of physical exercise.Investigations of the mechanisms underlying this effect revealed that exercise protected parvalbumin interneurons,probably via the suppression of neuroinflammation and improved integrity of blood-brain barrier.In summary,this work identified a previously unknown mechanism through which exercise improves cognitive rehabilitation in epilepsy. 展开更多
关键词 blood-brain barrier COGNITION HIPPOCAMPUS INTERNEURONS long-term potentiation microglial cell NEUROINFLAMMATION spatial memory temporal epilepsy treadmill exercise
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Metabolic syndrome’s new therapy:Supplement the gut microbiome 被引量:1
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作者 Yong-Wei Xu Jun Tian +2 位作者 Yan Song Ba-Cui Zhang Jing Wang 《World Journal of Diabetes》 SCIE 2024年第4期793-796,共4页
This letter to the editor discusses the publication on gut microbiome supple-mentation as therapy for metabolic syndrome.Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inf... This letter to the editor discusses the publication on gut microbiome supple-mentation as therapy for metabolic syndrome.Gut microbiome dysbiosis disrupts intestinal bacterial homeostasis and is related to chronic inflammation,insulin resistance,cardiovascular diseases,type 2 diabetes mellitus,and obesity.Previous research has found that increasing the abundance of beneficial microbiota in the gut modulates metabolic syndrome by reducing chronic inflammation and insulin resistance.Prebiotics,probiotics,synbiotics,and postbiotics are often used as supplements to increase the number of beneficial microbes and thus the produc-tion of short-chain fatty acids,which have positive effects on the gut microbiome and metabolic syndrome.In this review article,the author summarizes the available supplements to increase the abundance of beneficial gut microbiota and reduce the abundance of harmful microbiota in patients with metabolic disorders.Our group is also researching the role of the gut microbiota in chronic liver disease.This article will be of great help to our research.At the end of the letter,the mechanism of the gut microbiota in chronic liver disease is discussed. 展开更多
关键词 Gut microbiome Metabolic syndrome Diabetes mellitus Short-chain fatty acids Chronic liver disease
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Advances in All-Solid-State Lithium-Sulfur Batteries for Commercialization 被引量:1
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作者 Birhanu Bayissa Gicha Lemma Teshome Tufa +2 位作者 Njemuwa Nwaji Xiaojun Hu Jaebeom Lee 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第9期209-246,共38页
Solid-state batteries are commonly acknowledged as the forthcoming evolution in energy storage technologies.Recent development progress for these rechargeable batteries has notably accelerated their trajectory toward ... Solid-state batteries are commonly acknowledged as the forthcoming evolution in energy storage technologies.Recent development progress for these rechargeable batteries has notably accelerated their trajectory toward achieving commercial feasibility.In particular,all-solid-state lithium-sulfur batteries(ASSLSBs)that rely on lithium-sulfur reversible redox processes exhibit immense potential as an energy storage system,surpassing conventional lithium-ion batteries.This can be attributed predominantly to their exceptional energy density,extended operational lifespan,and heightened safety attributes.Despite these advantages,the adoption of ASSLSBs in the commercial sector has been sluggish.To expedite research and development in this particular area,this article provides a thorough review of the current state of ASSLSBs.We delve into an in-depth analysis of the rationale behind transitioning to ASSLSBs,explore the fundamental scientific principles involved,and provide a comprehensive evaluation of the main challenges faced by ASSLSBs.We suggest that future research in this field should prioritize plummeting the presence of inactive substances,adopting electrodes with optimum performance,minimizing interfacial resistance,and designing a scalable fabrication approach to facilitate the commercialization of ASSLSBs. 展开更多
关键词 All-solid-state lithium-sulfur batteries COMMERCIALIZATION Enhancement strategies Solid-state electrolytes Sulfurbased cathodes
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