Effect of Yiguanjian decoction on cell differentiation and proliferation in CCl_4-treated mice

AIM:To investigate the cellular mechanisms of action of Yiguanjian(YGJ) decoction in treatment of chronic hepatic injury.METHODS:One group of mice was irradiated,and received enhanced green fluorescent protein(EGFP)positive bone marrow transplants followed by 13 wk of CCl4 injection and 6 wk of oral YGJ administration.A second group of Institute for Cancer Research mice was treated with 13 wk of CCl4 injection and 6 wk of oral YGJadministration.Liver function,histological changes in the liver,and Hyp content were analyzed.The expression of-smooth muscle actin(-SMA),F4/80,albumin(Alb),EGFP,mitogen-activated protein kinase-2(PKM2),Ki-67,fetoprotein(AFP),monocyte chemotaxis protein-1 and CC chemokine receptor 2 were assayed.RESULTS:As hepatic damage progressed,EGFP-positive marrow cells migrated into the liver and were mainly distributed along the fibrous septa.They showed a conspicuous coexpression of EGFP with-SMA and F4/80 but no coexpression with Alb.Moreover,the expression of PKM2,AFP and Ki-67 was enhanced dynamically and steadily over the course of liver injury.YGJ abrogated the increases in the number of bone marrow-derived fibrogenic cells in the liver,inhibited expression of both progenitor and mature hepatocyte markers,and reduced fibrogenesis.CONCLUSION:YGJ decoction improves liver fibrosis by inhibiting the migration of bone marrow cells into the liver as well as inhibiting their differentiation and suppressing the proliferation of both progenitors and hepatocytes in the injured liver.

How to assess the severity of atrophic gastritis

Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.

Detecting Non-Stationarity for Auscultation Signal of Traditional Chinese Medicine

The information about the nonstationarity of the aus-cultation signal is utilized in this paper to objectively and auto-matically identify healthy people and patients with qi-deficiency or yin-deficiency. In order to characterize the nonstationarity of the sound signal,the nonlinear cross-prediction method is used to extract features from the signal. A feature selection method based on conditional mutual information maximization criterion （CMIM） is implemented to find an optimal feature set. By means of the support vector machine （SVM） classifier,three common states （healthy,qi-deficiency and yin-deficiency） in traditional Chinese medicine are distinguished using the feature set,and a satisfactory classification accuracy of 80% is achieved in the experiment. In conclusion,the analysis based on the nonstationarity of the sound signal provides an alternative and outstanding approach to the objective auscultation of traditional Chinese medicine （TCM）.

Research on Acupuncture-moxibustion for Dry Eye Syndrome

干燥眼睛症候群(DES ) 是通常遇到的眼科的疾病，与相对高的发生，并且期望一个有效治疗方法。没有引起一处损伤，针灸艾灸治疗支持眼泪的腺的眼泪生产，并且因此在对待 DES 有一个大优点。通过文学分析，这篇文章在对待 DES 在期间在针灸艾灸的临床的实践和机制总结了研究进步最近 10 年，为为 DES 为针灸艾灸的应用程序提供珍贵引用。