Transmetalation of carborane-fused zirconacycles to Cu(Ⅱ) induces the C-C coupling reaction to form four-membered rings. This serves as a new efficient and general methodology for the generation of a series of carbor...Transmetalation of carborane-fused zirconacycles to Cu(Ⅱ) induces the C-C coupling reaction to form four-membered rings. This serves as a new efficient and general methodology for the generation of a series of carborane-fused cyclobutenes and cyclobutanes. A reaction mechanism involving transmetalation to Cu(Ⅱ) and reductive elimination is proposed.展开更多
A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/trifluoromethylation of 2-alkynylanilines and Umemoto's reagent under effect of CuBr.The reaction fe...A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/trifluoromethylation of 2-alkynylanilines and Umemoto's reagent under effect of CuBr.The reaction features the use of cheap copper salt,mild reaction conditions and high yield of products.The preliminary mechanism study indicates the solvent dimethylacetamide acts as the role of dealkylation.展开更多
of main observation and conclusion A palladium catalyzed oxidative annulation of 1-hydroxy-o-carborane with internal alkynes via regioselective B(3)—H bond activation has been developed for facile synthesis of a seri...of main observation and conclusion A palladium catalyzed oxidative annulation of 1-hydroxy-o-carborane with internal alkynes via regioselective B(3)—H bond activation has been developed for facile synthesis of a series of QB-substituted carborane-fused oxaboroles.These molecules can undergo intramolecular oxidative dehydrogenative coupling to afford carborane-fused large n systems for potential applications in organic materials.The reaction mechanism is also proposed,involving hydroxy deprotonation,nucleopalladation of alkyne,regioselective electrophilic B—H substitution and reductive eiiimination.展开更多
Copper catalyzed enantioselective [4+2] annulations of D-A cyclobutanes and aldehydes have been developed. In the presence of a side arm modified chiral bisoxazoline (SaBOX) ligand, the [4+2] annulations proceeded...Copper catalyzed enantioselective [4+2] annulations of D-A cyclobutanes and aldehydes have been developed. In the presence of a side arm modified chiral bisoxazoline (SaBOX) ligand, the [4+2] annulations proceeded smoothly with a broad substrate scope. 22 examples were studied, leading to the corresponding products with various functional groups in 41%-99% yields with 〉99/1 dr and 90%-96% ee. The resulting product with two ester groups was mono-reduced, giving the corresponding product in excellent diastereoselectivity without loss of the enantiopurity.展开更多
A Pd-catalyzed asymmetric decarboxylative[4+2]cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach.The reaction provides an efficient protocol for constructing a s...A Pd-catalyzed asymmetric decarboxylative[4+2]cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach.The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo-and enantioselectivities.展开更多
α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes.As such,a variety of optically act...α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes.As such,a variety of optically activeβ-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields(42%–99%)and moderate to good level of enantiomeric excess(up to 87%ee).展开更多
基金supported by the Research Grants Council of the Hong Kong Special Administration Region (404011)the National Natural Science Foundation of China (21372245 to QIU ZaoZao)
文摘Transmetalation of carborane-fused zirconacycles to Cu(Ⅱ) induces the C-C coupling reaction to form four-membered rings. This serves as a new efficient and general methodology for the generation of a series of carborane-fused cyclobutenes and cyclobutanes. A reaction mechanism involving transmetalation to Cu(Ⅱ) and reductive elimination is proposed.
基金Financially supported by the Major Basic Research Development Program(No.2011CB808706)National Natural Science Foundation of China(Nos.21272251,21121062 and 21032007)Chinese Academy of Sciences,the Technology Commission of Shanghai Municipality,and the Croucher Foundation of Hong Kong.
文摘A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/trifluoromethylation of 2-alkynylanilines and Umemoto's reagent under effect of CuBr.The reaction features the use of cheap copper salt,mild reaction conditions and high yield of products.The preliminary mechanism study indicates the solvent dimethylacetamide acts as the role of dealkylation.
基金This work was supported by grants from the National NaturalScience Foundation of China(No.21772223)the Science andTechnology Commission ofShanghai Municipality(No.18590760800)the China Postdoctoral Science Foundation(No.BX20180341 to R.C.), the Shanghai Postdoctoral Excellence Program (No. 2018027 to R. C.), the Chinese Academy of Sciences,and Hong Kong Research Grants Council (No.14305017).
文摘of main observation and conclusion A palladium catalyzed oxidative annulation of 1-hydroxy-o-carborane with internal alkynes via regioselective B(3)—H bond activation has been developed for facile synthesis of a series of QB-substituted carborane-fused oxaboroles.These molecules can undergo intramolecular oxidative dehydrogenative coupling to afford carborane-fused large n systems for potential applications in organic materials.The reaction mechanism is also proposed,involving hydroxy deprotonation,nucleopalladation of alkyne,regioselective electrophilic B—H substitution and reductive eiiimination.
基金We thank for the financial support from the National Natural Science Foundation of China (Nos. 21421091 and 21432011), the National Basic Research Program of China (973 Program) (2015CB856600), the Natural Science Foundation of Shanghai (17ZR1436900), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000) and the Youth Innovation Promotion Association CAS (2017301). We thank Dr. Xue-Bing Leng for X-ray crystal analysis
文摘Copper catalyzed enantioselective [4+2] annulations of D-A cyclobutanes and aldehydes have been developed. In the presence of a side arm modified chiral bisoxazoline (SaBOX) ligand, the [4+2] annulations proceeded smoothly with a broad substrate scope. 22 examples were studied, leading to the corresponding products with various functional groups in 41%-99% yields with 〉99/1 dr and 90%-96% ee. The resulting product with two ester groups was mono-reduced, giving the corresponding product in excellent diastereoselectivity without loss of the enantiopurity.
基金financial support from the National Natural Science Foundation of China (NSFC, Nos. 21772215, 21532010 and 21472214)the Strategic Priority Research Program of the Chinese Academy of Sciences (No. XDB20030100)+2 种基金the Chinese Academy of Sciencesthe Technology Commission of Shanghai Municipalitythe Croucher Foundation of Hong Kong
文摘A Pd-catalyzed asymmetric decarboxylative[4+2]cycloaddition of 3-nitroindoles and vinyl benzoxazinanones is developed through a dearomatization approach.The reaction provides an efficient protocol for constructing a series of chiral tetrahydro-5H-indolo[2,3-b]quinolines in high yields and with excellent diastereo-and enantioselectivities.
基金supported by grants from National Key Program (No. 2016YFA0200302, Study on application and preparation of aroma nanocomposites)National Natural Science Foundation of China (NSFC, No. 21472213)Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant
文摘α,β-Alkynyl ketoesters were introduced to the enantioselective Henry reaction(nitroaldol condensation)with nitromethane catalyzed by tartaric acid derived chiral iminophosphoranes.As such,a variety of optically activeβ-nitro-substituted tertiary alcohols bearing alkyne moieties were obtained in good to excellent yields(42%–99%)and moderate to good level of enantiomeric excess(up to 87%ee).