Objective To investigate the role of mifepristone in regulating cytokines of materno-fetal interface and serum of human early gestationMethods Thirty-five women with early pregnancy received mifepristone 50 mg orallyo...Objective To investigate the role of mifepristone in regulating cytokines of materno-fetal interface and serum of human early gestationMethods Thirty-five women with early pregnancy received mifepristone 50 mg orallyon study d 1 and d 2, respectively, followed by undergoing artificial abortion to getdecidua and villi on study d 3. Twenty-five women with early pregnancy withoutmifepristone administration as control also underwent artificial abortion to get de-cidua and villi. The expressions of TGF-β1 and TGF-β1 receptor mRNA in the earlydecidua and villi were assessed by using RT-PCR . The concentrations of serum TNF-α were measured by radioimmunoassay.Results The decidual expressions of TGF- β1 mRNA and TGF-β1 receptor mRNA in thetreated group were significantly lower than those of the control (P<0.05), while thevillus expressions of TGF-β1 and TGF-β1 receptor mRNA in the treated group were notsignificantly different from those of the control (P>0.05). The serum TNF-β1 levelselevated significantly after mifepristone treatment.Conclusion The antigestational effect of mifepristone might act through suppressingthe transcription of TGF-β1 and TGF-β1 receptor in the decidua and increasing theserum TNF-α level, which interfered in the materno-fetal interface Th2 bias.展开更多
The Stainless steel ring(SSR),VCu200 and TCu220C were ic randomized comparison for eight years in a cohort of 4,490 subjects covering 16 centres in 9 provinces andmunicipalities.The follow-up rate at the end of the ei...The Stainless steel ring(SSR),VCu200 and TCu220C were ic randomized comparison for eight years in a cohort of 4,490 subjects covering 16 centres in 9 provinces andmunicipalities.The follow-up rate at the end of the eithth year was 90.33%.The cumulative continuation rates were 47.06 per 100 women at the end of foe eighth year for SSR,54.05 for VCu200 and 61.14 for TCu220C.The cumulative pregnancy rates for VCu200and TCu220C were 10.35 and 8.94 per 100 women respectively,significantly lower than24.14 for SSR. There were significant differences in eight-year expulsion rates amongSSR(21.69%),VCu200(13.05%)and TCu220C(7.48%).The removal for bleedingand/or pain was the lowest in SSR;and no signaificant differences were found betweenVCu200 and TCu200C.but foe rate ws getting higher in VCu200 at the end of the eighthyear than in TCu220C.The discontinued use of IUD for desire to become pregnant in rural area was extremely higher than in urban area. The risk of pregnancy and expulsionwas in association with the types of IUD in this study,age at insertion,previous use ofIUD and pregnancy frequency prior to insertion. The risk of pregnancy and expulsion forVCu200 and TCu220C was significantly lower than that for SSR. Failure risks were associated with age at insertion, the types of IUD in this study and pregnancy frequencyprior to insertion,and failure risk in SSR was still higher than in VCu200 and TCu220Cat the end of the eighth year. The study revealed that TCu220C was of good long-termsafety,efficacy,and acceptability.展开更多
文摘Objective To investigate the role of mifepristone in regulating cytokines of materno-fetal interface and serum of human early gestationMethods Thirty-five women with early pregnancy received mifepristone 50 mg orallyon study d 1 and d 2, respectively, followed by undergoing artificial abortion to getdecidua and villi on study d 3. Twenty-five women with early pregnancy withoutmifepristone administration as control also underwent artificial abortion to get de-cidua and villi. The expressions of TGF-β1 and TGF-β1 receptor mRNA in the earlydecidua and villi were assessed by using RT-PCR . The concentrations of serum TNF-α were measured by radioimmunoassay.Results The decidual expressions of TGF- β1 mRNA and TGF-β1 receptor mRNA in thetreated group were significantly lower than those of the control (P<0.05), while thevillus expressions of TGF-β1 and TGF-β1 receptor mRNA in the treated group were notsignificantly different from those of the control (P>0.05). The serum TNF-β1 levelselevated significantly after mifepristone treatment.Conclusion The antigestational effect of mifepristone might act through suppressingthe transcription of TGF-β1 and TGF-β1 receptor in the decidua and increasing theserum TNF-α level, which interfered in the materno-fetal interface Th2 bias.
文摘The Stainless steel ring(SSR),VCu200 and TCu220C were ic randomized comparison for eight years in a cohort of 4,490 subjects covering 16 centres in 9 provinces andmunicipalities.The follow-up rate at the end of the eithth year was 90.33%.The cumulative continuation rates were 47.06 per 100 women at the end of foe eighth year for SSR,54.05 for VCu200 and 61.14 for TCu220C.The cumulative pregnancy rates for VCu200and TCu220C were 10.35 and 8.94 per 100 women respectively,significantly lower than24.14 for SSR. There were significant differences in eight-year expulsion rates amongSSR(21.69%),VCu200(13.05%)and TCu220C(7.48%).The removal for bleedingand/or pain was the lowest in SSR;and no signaificant differences were found betweenVCu200 and TCu200C.but foe rate ws getting higher in VCu200 at the end of the eighthyear than in TCu220C.The discontinued use of IUD for desire to become pregnant in rural area was extremely higher than in urban area. The risk of pregnancy and expulsionwas in association with the types of IUD in this study,age at insertion,previous use ofIUD and pregnancy frequency prior to insertion. The risk of pregnancy and expulsion forVCu200 and TCu220C was significantly lower than that for SSR. Failure risks were associated with age at insertion, the types of IUD in this study and pregnancy frequencyprior to insertion,and failure risk in SSR was still higher than in VCu200 and TCu220Cat the end of the eighth year. The study revealed that TCu220C was of good long-termsafety,efficacy,and acceptability.
