What is already known about this topic?The prevalence of COPD in Chinese individuals aged 50 years and above was obviously higher than that in younger adults,but the risk factors for this age group were unclear.What i...What is already known about this topic?The prevalence of COPD in Chinese individuals aged 50 years and above was obviously higher than that in younger adults,but the risk factors for this age group were unclear.What is added by this report?The prevalence was estimated at 12.8%and 5.7%for males and females over 50 in 2020–2021,with confirmed risk factors of cigarette smoking,a family history of respiratory diseases,respiratory symptoms,and a history of cough or respiratory diseases during childhood.What are the implications for public health practice?The findings may help clinicians and the public identify individuals at high risk of COPD and take targeted measures in a timely manner.展开更多
Background and Aims:Previous studies reported that serum resistin levels were remarkably changed in patients with nonalcoholic fatty liver disease(NAFLD)but the conclusions were inconsistent.The aim of this study was ...Background and Aims:Previous studies reported that serum resistin levels were remarkably changed in patients with nonalcoholic fatty liver disease(NAFLD)but the conclusions were inconsistent.The aim of this study was to investigate accurate serum resistin levels in adult patients with NAFLD.Methods:A complete literature research was conducted in the PubMed,Embase,and Cochrane Library databases,and all the available studies up to 7 May 2020 were reviewed.The pooled standardized mean difference(SMD)values were calculated to investigate the serum resistin levels in patients with NAFLD and healthy controls.Results:A total of 28 studies were included to investigate the serum resistin levels in patients with NAFLD.Patients with NAFLD had higher serum resistin levels than controls(SMD=0.522,95%confidence interval[CI]:0.004–1.040,I2=95.9%).Patients with nonalcoholic steatohepatitis(NASH)had lower serum resistin levels than the healthy controls(SMD=−0.44,95%CI:−0.83–0.55,I2=74.5%).In addition,no significant difference of serum resistin levels was observed between patients with NAFL and healthy controls(SMD=−0.34,95%CI:−0.91–0.23,I2=79.6%)and between patients with NAFL and NASH(SMD=0.15,95%CI:−0.06–0.36,I2=0.00%).Furthermore,subgroup and sensitivity analyses suggested that heterogeneity did not affect the results of meta-analysis.Conclusions:This meta-analysis investigated the serum resistin levels in adult patients with NAFLD comprehensively.Patients with NAFLD had higher serum resistin levels and patients with NASH had lower serum resistin levels than healthy controls.Serum resistin could serve as a potential biomarker to predict the development risk of NAFLD.展开更多
基金Supported by the National Natural Science Foundation of China(82388102,82192900,82192901,82192904)The CKB baseline survey and the first re-survey were supported by a grant from the Kadoorie Charitable Foundation in Hong Kong.The long-term follow-up is supported by grants from the UK Wellcome Trust(212946/Z/18/Z,202922/Z/16/Z,104085/Z/14/Z,088158/Z/09/Z)+2 种基金grants(2016YFC0900500)from the National Key R&D Program of ChinaNational Natural Science Foundation of China(81390540,91846303,81941018)Chinese Ministry of Science and Technology(2011BAI09B01).
文摘What is already known about this topic?The prevalence of COPD in Chinese individuals aged 50 years and above was obviously higher than that in younger adults,but the risk factors for this age group were unclear.What is added by this report?The prevalence was estimated at 12.8%and 5.7%for males and females over 50 in 2020–2021,with confirmed risk factors of cigarette smoking,a family history of respiratory diseases,respiratory symptoms,and a history of cough or respiratory diseases during childhood.What are the implications for public health practice?The findings may help clinicians and the public identify individuals at high risk of COPD and take targeted measures in a timely manner.
基金This study was supported by a grant from the National Natural Science Foundation of China(No.31770837)which plays a significant role in the design of the study and data collection,analysis nor interpretation,nor in the writing of the manuscript.
文摘Background and Aims:Previous studies reported that serum resistin levels were remarkably changed in patients with nonalcoholic fatty liver disease(NAFLD)but the conclusions were inconsistent.The aim of this study was to investigate accurate serum resistin levels in adult patients with NAFLD.Methods:A complete literature research was conducted in the PubMed,Embase,and Cochrane Library databases,and all the available studies up to 7 May 2020 were reviewed.The pooled standardized mean difference(SMD)values were calculated to investigate the serum resistin levels in patients with NAFLD and healthy controls.Results:A total of 28 studies were included to investigate the serum resistin levels in patients with NAFLD.Patients with NAFLD had higher serum resistin levels than controls(SMD=0.522,95%confidence interval[CI]:0.004–1.040,I2=95.9%).Patients with nonalcoholic steatohepatitis(NASH)had lower serum resistin levels than the healthy controls(SMD=−0.44,95%CI:−0.83–0.55,I2=74.5%).In addition,no significant difference of serum resistin levels was observed between patients with NAFL and healthy controls(SMD=−0.34,95%CI:−0.91–0.23,I2=79.6%)and between patients with NAFL and NASH(SMD=0.15,95%CI:−0.06–0.36,I2=0.00%).Furthermore,subgroup and sensitivity analyses suggested that heterogeneity did not affect the results of meta-analysis.Conclusions:This meta-analysis investigated the serum resistin levels in adult patients with NAFLD comprehensively.Patients with NAFLD had higher serum resistin levels and patients with NASH had lower serum resistin levels than healthy controls.Serum resistin could serve as a potential biomarker to predict the development risk of NAFLD.
