This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis ...This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these pollutants.Our analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the environment.Due to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being recoverable.The in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater treatment.This concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.展开更多
Appropriate oral hygiene significantly reduces the possibility of oral infections.However,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral health.Recently,h...Appropriate oral hygiene significantly reduces the possibility of oral infections.However,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral health.Recently,herbal compounds have gained interest in maintaining oral health.Extracts of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and periodontics.Plectranthus amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral health.The COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb SARS-CoV-2.Oral cavity is among the gateways for virus entry into saliva.Saliva is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the mouth.This enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial dysfunction.This review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.展开更多
Objective:To explore the effect of Cassia fistula on collagenⅡ-induced arthritis in rats.Methods:The effect of 250 and 500 mg/kg chloroform and hydroalcoholic extract of Cassia fistula leaf on collagenⅡ-induced arth...Objective:To explore the effect of Cassia fistula on collagenⅡ-induced arthritis in rats.Methods:The effect of 250 and 500 mg/kg chloroform and hydroalcoholic extract of Cassia fistula leaf on collagenⅡ-induced arthritis was investigated by evaluating paw volume,arthritis index,spleen index,and biochemical parameters.Histopathological analysis and docking study were also performed.Results:A dose-dependent reduction in paw volume,arthritic index,and spleen index was observed following oral administration of the chloroform and hydroalcoholic extracts.Treatment with Cassia fistula extracts reduced tumor necrosis factor-α,interleukin(IL)-1β,IL-6,prostaglandin E_(2),aspartate aminotransferase,alanine aminotransferase,total leucocyte count,and erythrocyte sedimentation rate while increasing IL-10 level.In addition,Cassia fistula extracts improved joint architecture,and prevented cartilage and bone destruction.Docking analysis demonstrated that the physcion,1-octacosanol,5,3’,4’-trihydroxy-6-methoxy-7-O-α-Lrhamnopyranosyl-(1,2)-O-β-D-galactopyranoside and scopoletin may be responsible for the anti-arthritic effect of Cassia fistula.Conclusions:Cassia fistula suppresses the progression of collagenⅡ-induced arthritis by lowering the inflammatory factors,decreasing paw volume and arthritic index,and alleviating joint architecture.However,further studies are required to confirm the bioactive molecule responsible for the anti-arthritic potential of Cassia fistula.展开更多
In this study, aluminum oxide (Al2O3) nanoparticles (NPs) were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis tim...In this study, aluminum oxide (Al2O3) nanoparticles (NPs) were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis time on the shape and size of the resulting NPs were investi- gated. The Al2O3 NPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis/differential thermal analysis, energy-dispersive X-ray analysis, and ultraviolet-visible spectroscopy. Moreover, the Al2O3 NPs were explored for photocatalytic degradation of malachite green (MG) dye under sunlight irradiation via two processes: ad- sorption followed by photocatalysis; coupled adsorption and photocatalysis. The coupled process exhibited a higher photodegradation effi- ciency (45%) compared to adsorption followed by photocatalysis (32%). The obtained kinetic data was well fitted using a pseudo-first-order model for MG degradation.展开更多
Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are ...Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis.MicroRNAs(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and invasion.Any dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer progression.MicroRNA-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target gene.The upregulation of miR-21 is observed in many instances of breast cancer.Our review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target genes.We discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its detection.This will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care.展开更多
OBJECTIVE To evaluate antioxidant,anti-inflammatory,antimicrobial activities of Pinus Roxburghii stem bark in vitro and evaluation of in vivo anti-osteoporotic activity in female rats.METHODS The antioxidant activity ...OBJECTIVE To evaluate antioxidant,anti-inflammatory,antimicrobial activities of Pinus Roxburghii stem bark in vitro and evaluation of in vivo anti-osteoporotic activity in female rats.METHODS The antioxidant activity of plant extract was assessed using DPPH,nitric oxide and H2O2 radical scavenging methods.In vitro anti-inflammatory activity was evaluated using albumin denaturation,membrane stabilization methods at various concentrations.The antibacterial and anti-fungal activity of extracts was also done against micro-organisms:Pseudomonas aurignosa,Escherichia coli,Staphylococcus aureus,Bacillus subtilis and Candida albicans.Quantitative analysis of total phenolics,flavonoids and tannins were also estimated.Female Wistar albino rats(220-260g)were employed and ovaries were surgically removed bilaterally in anaesthesia which causes post-menopausal syndrome in all the groups except sham operated rats.Extracts of Pinus roxburghii stem at 100 and 200mg·kg-1,po.and tamoxifen as standard 1mg·kg-1,po.were given.Acute toxicity study was also done.RESULTS Treatment with Pinus roxburghii extract in two doses significantly(P<0.05)ameliorated surgical ovariectomy induced biochemical and biomechanical changes like decrease in bone density,bone strength,alkaline phosphatase,serum calcium,serum phosphorous and increase in urine hydroxylproline levels.Plant extract also has significant(P<0.05)antioxidant,antimicrobial and anti-inflammatory activities.CONCLUSION The assessments done in present investigation may conclude that the constituents of Pinus roxburghii has significant potential in ameliorating oxidative,inflammatory reactions and possesses anti-microbial;osteobalstic and osteoclastic activities used for calcium homeostatis and improved bone strength in female rats.展开更多
A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with ju...A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with juvenile cells.展开更多
Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the m...Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/Ha), Hence these diseases can be managed by successful application of Biocontrol agents.展开更多
This paper presents a novel application of metaheuristic algorithmsfor solving stochastic programming problems using a recently developed gaining sharing knowledge based optimization (GSK) algorithm. The algorithmis b...This paper presents a novel application of metaheuristic algorithmsfor solving stochastic programming problems using a recently developed gaining sharing knowledge based optimization (GSK) algorithm. The algorithmis based on human behavior in which people gain and share their knowledgewith others. Different types of stochastic fractional programming problemsare considered in this study. The augmented Lagrangian method (ALM)is used to handle these constrained optimization problems by convertingthem into unconstrained optimization problems. Three examples from theliterature are considered and transformed into their deterministic form usingthe chance-constrained technique. The transformed problems are solved usingGSK algorithm and the results are compared with eight other state-of-the-artmetaheuristic algorithms. The obtained results are also compared with theoptimal global solution and the results quoted in the literature. To investigatethe performance of the GSK algorithm on a real-world problem, a solidstochastic fixed charge transportation problem is examined, in which theparameters of the problem are considered as random variables. The obtainedresults show that the GSK algorithm outperforms other algorithms in termsof convergence, robustness, computational time, and quality of obtainedsolutions.展开更多
The field of solid modeling has created numerous techniques for unambiguous computer representations of three-dimensional objects. Its data structures and algorithms have been used in a broad range of applications: Co...The field of solid modeling has created numerous techniques for unambiguous computer representations of three-dimensional objects. Its data structures and algorithms have been used in a broad range of applications: Computer-Aided Design and Computer-Aided Manufacturing (CAD/ CAM), robotics, computer vision, computer graphics and visualization, virtual reality, etc. This research paper is used to generate process plan from feature-based modeling, based on an integrated geometric modeling system that supports both feature-based modeling and information storage. Present system is developed only for milling components and limited to selective machining features for prismatic components and further implemented for more machining features to develop algorithms for modeling the components through the input of machining features. As a result, feature information is directly available to downstream activities, and feature extraction is no longer needed. The various systematic steps involved in this approach are study of Design, identification of Features, selection of Processes, Tools and Machines, Machining and Inspection [DFPTMMI]. Machining features generated in the design stage are recognized and stored under the Visual Basic control of CATIA software ActiveX interface. Algorithms are developed for individual features and these algorithms are embedded in Visual Basic forms. This system is discussed and suited for 2.5 Dimensional part approach, however, that can be extended to 3 dimensional prismatic part and complex features machining. Finally a process planning chart has been presented as a model process planning.展开更多
After the discovery of hexagonal ferrites or hexaferrites, it has been become important materials commercially and technically to study which is still growing on. In this article, we have reviewed about the M-type hex...After the discovery of hexagonal ferrites or hexaferrites, it has been become important materials commercially and technically to study which is still growing on. In this article, we have reviewed about the M-type hexaferrites including their structural, synthesis techniques and important magnetic properties. The role of experimental synthesizing techniques adopted for preparation of M-type hexaferrites on the various parameters studied in this review paper. The substitution of holonium in BaM ferrite reduces the value of coercivity but not saturation magnetization and ramanence and the cobalt-titanium substituted ferrites were the most important M-type ferrites in the field of application in microwave properties and magnetic field industry.展开更多
Sodium potassium niobate (KNN) (K0.5Na0.5NbO3) nanopowder with a mean particle size of about 20 - 30 nm was synthesized by wet chemical route using Nb2O5 as Nb source. A solution of K, Na and Nb cations was prepared, ...Sodium potassium niobate (KNN) (K0.5Na0.5NbO3) nanopowder with a mean particle size of about 20 - 30 nm was synthesized by wet chemical route using Nb2O5 as Nb source. A solution of K, Na and Nb cations was prepared, which resulted in a clear gel after the thermal treatment. Phase analysis, microstructure and morphology of the powder were determined by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Field Emission Scanning Electron Microscopy (FESEM). The obtained gel was first analyzed by Thermo Gravimetric Analyzer (TGA) and Differential Scanning Calorimetry (DSC), and then calcined at different temperatures of 400℃, 500℃, 600℃ and 700℃. The X-Ray Diffraction (XRD) patterns of the synthesized samples confirmed the formation of the orthorhombic crystal phase of K0.5Na0.5NbO3 at 500?C, a temperature significantly lower than that typically used in the conventional mixed oxide route. The process developed in this work is convenient to realize the mass production of KNN nanopowders at low cost and suitable for various industrial applications.展开更多
MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the ...MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.展开更多
Cloud computing is currently an embryonic domain in the area of information technology that possesses the power of transforming the way information technology (IT) services are delivered and maintained in the busine...Cloud computing is currently an embryonic domain in the area of information technology that possesses the power of transforming the way information technology (IT) services are delivered and maintained in the business world. Pay as per the usage kind of cost structure coupled with delivery of computing services through internet makes cloud computing an exciting and potential growth oriented information technology model compared with conventional computing services delivery models. Various additional features like scalability, flexibility and easy deployment process creates a window for the organizations even relatively smaller in size to get benefitted by the highly advanced & modern technologies without incurring substantial cost. In spite of so many benefits of this new delivery model, concerns are beginning to grow about how safe an environment it is. Despite of all the hype surrounding the cloud, enterprise customers are still reluctant to deploy their business in the cloud. Security is one of the major issues which reduces the growth of cloud computing and complications with data privacy and data protection continue to plague the market. Other related concerns associated with the adoption of cloud computing include trust on service providers, loss of control and compliance issues. This paper is an attempt to explore security & trust issues linked with cloud computing adoption in the Small and Medium Enterprises (SME) sector.展开更多
The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular homeostasis.The mTOR signali...The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular homeostasis.The mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating kinases.mTOR signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor signaling.The emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human malignancies.Here,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and autophagy.Additionally,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR signaling.Importantly,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug resistance.Here,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.展开更多
Vacancy engineering in metal sulfides has garnered enormous attention from researchers because of their outstanding ability to modulate the optical and physiochemical properties of photocatalysts.Typically,in the case...Vacancy engineering in metal sulfides has garnered enormous attention from researchers because of their outstanding ability to modulate the optical and physiochemical properties of photocatalysts.Typically,in the case of sulfides,the catalytic activity is drastically hindered by the quick reassembly of excitons and the photocorrosion effect.Hence designing and generating S-vacancies in metal sulfides has emerged as a potential strategy for attaining adequate water splitting to generate H_(2) and O_(2) because of the simulta-neous improvement in the optoelectronic features.However,developing efficient catalysts that manifest optimal photo(electro)catalytic performance for large-scale applicability remains challenging.Therefore,it is of utmost interest to explore the insightful features of creating S-vacancy and study their impact on catalytic performance.This review article aims to comprehensively highlight the roles of S-vacancy in sulfides for amended overall water-splitting activity.The photocatalytic features of S-vacancies modulated metal sulfides are deliberated,followed by various advanced synthetic and characterization techniques for effectual generation and identification of vacancy defects.The specific aspects of S-vacancies in refin-ing the optical absorption range charge carrier dynamics,and photoinduced surface chemical reactions are critically examined for overall water splitting applications.Finally,the vouchsafing outlooks and op-portunities confronting the defect-engineered(S-vacancy)metal sulfides-based photocatalysts have been summarized.展开更多
Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nano...Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.展开更多
基金funded by the following grants, including the Key Research and Development Program of Shaanxi Province (No. 2023-LL-QY-42)the Xi'an University of Architecture and Technology Research Initiation Grant Program (No. 1960323102)the Xi'an University of Architecture and Technology Special Program for Cultivation of Frontier Interdisciplinary Fields (No. 1960523142)。
文摘This review paper explores the efficacy of magnesium ferrite-based catalysts in photocatalytic degradation of organic contaminates(antibiotic and dyes).We report the influence of different doping strategies,synthesis methods,and composite materials on the degradation efficiency of these pollutants.Our analysis reveals the versatile and promising nature of magnesium ferrite-based catalysts,offering the valuable insights into their practical application for restoring the environment.Due to the smaller band gap and magnetic nature of magnesium ferrite,it holds the benefit of utilising the broader spectrum of light while also being recoverable.The in-depth analysis of magnesium ferrites'photocatalytic mechanism could lead to the development of cheap and reliable photocatalyst for the wastewater treatment.This concise review offers a thorough summary of the key advancements in this field,highlighting the pivotal role of the magnesium ferrite based photocatalysts in addressing the pressing global issue of organic pollutants in wastewater.
文摘Appropriate oral hygiene significantly reduces the possibility of oral infections.However,dental caries and periodontal diseases are major oral health issues causing chronic diseases due to poor oral health.Recently,herbal compounds have gained interest in maintaining oral health.Extracts of burdock root(Arctium),noni fruit(Morinda citrifolia),and neem leaf(Azadirachta indica)are now used as intracanal medicaments in endodontics and periodontics.Plectranthus amboinicus species and other plants produces essential oil likeβ-caryophyllene,p-cymene,andγ-terpinene can exhibit antibacterial activity;highlighting phytoconstituents plays a vital role in oral health.The COVID-19 pandemic highlighted the importance of hygiene and sanitization,to curb SARS-CoV-2.Oral cavity is among the gateways for virus entry into saliva.Saliva is a potential reservoir of SARS-CoV-2,and there is an increased risk of infection if there is any fissure in the mouth.This enables entry of virus into the vascular system through gingival or periodontal pocket,possibly reaching lung periphery then to lung vessels by interacting with endothelial surface receptors triggering pulmonary vasoconstriction and lung damage due to endothelial dysfunction.This review aims to draw attention to the possible route of SARS-CoV-2 infection via the oral cavity and the importance of oral hygiene against COVID-19.
基金supported by the Institute of Pharmaceutical Sciences,Kurukshetra University,Kurukshetra,Haryana,India,and Govt.College of Pharmacy,Rohru,District Shimla,Himachal Pradesh,India。
文摘Objective:To explore the effect of Cassia fistula on collagenⅡ-induced arthritis in rats.Methods:The effect of 250 and 500 mg/kg chloroform and hydroalcoholic extract of Cassia fistula leaf on collagenⅡ-induced arthritis was investigated by evaluating paw volume,arthritis index,spleen index,and biochemical parameters.Histopathological analysis and docking study were also performed.Results:A dose-dependent reduction in paw volume,arthritic index,and spleen index was observed following oral administration of the chloroform and hydroalcoholic extracts.Treatment with Cassia fistula extracts reduced tumor necrosis factor-α,interleukin(IL)-1β,IL-6,prostaglandin E_(2),aspartate aminotransferase,alanine aminotransferase,total leucocyte count,and erythrocyte sedimentation rate while increasing IL-10 level.In addition,Cassia fistula extracts improved joint architecture,and prevented cartilage and bone destruction.Docking analysis demonstrated that the physcion,1-octacosanol,5,3’,4’-trihydroxy-6-methoxy-7-O-α-Lrhamnopyranosyl-(1,2)-O-β-D-galactopyranoside and scopoletin may be responsible for the anti-arthritic effect of Cassia fistula.Conclusions:Cassia fistula suppresses the progression of collagenⅡ-induced arthritis by lowering the inflammatory factors,decreasing paw volume and arthritic index,and alleviating joint architecture.However,further studies are required to confirm the bioactive molecule responsible for the anti-arthritic potential of Cassia fistula.
文摘In this study, aluminum oxide (Al2O3) nanoparticles (NPs) were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis time on the shape and size of the resulting NPs were investi- gated. The Al2O3 NPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis/differential thermal analysis, energy-dispersive X-ray analysis, and ultraviolet-visible spectroscopy. Moreover, the Al2O3 NPs were explored for photocatalytic degradation of malachite green (MG) dye under sunlight irradiation via two processes: ad- sorption followed by photocatalysis; coupled adsorption and photocatalysis. The coupled process exhibited a higher photodegradation effi- ciency (45%) compared to adsorption followed by photocatalysis (32%). The obtained kinetic data was well fitted using a pseudo-first-order model for MG degradation.
文摘Breast cancer,also recognized as the principal cause of cancer-related deaths among women,is the second most familiar and prevalent form of cancer.New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis.MicroRNAs(miRNAs),a class of non-coding RNAs,are known to control the biological processes involving transcription,post-transcriptional and covalent modifications,splicing,translation,cell differentiation,proliferation,apoptosis,cancer progression,and invasion.Any dysregulation in miRNA expression,demonstrating their oncogenic and tumor-suppressive functions,contributes to cancer progression.MicroRNA-21(miR-21),an‘onco-miR’in breast cancer,is involved in tumor progression and metastasis by suppressing the activity of the target gene via its interaction with the 3’UTR of the target gene.The upregulation of miR-21 is observed in many instances of breast cancer.Our review aims to summarize the current understanding of miR-21 in the regulation of important cellular functions via regulation of its target genes.We discuss its biosynthesis,oncogenic function in breast cancer,and different methods used for its detection.This will increase the current understanding of the role of miR-21 in breast cancer tumorigenesis,which will offer a perception of using miR-21 as an early detection molecular prognostic and diagnostic biomarker and as a therapeutic target in breast cancer care.
基金The project supported by Department of Science and Technology(DST),New Delhi
文摘OBJECTIVE To evaluate antioxidant,anti-inflammatory,antimicrobial activities of Pinus Roxburghii stem bark in vitro and evaluation of in vivo anti-osteoporotic activity in female rats.METHODS The antioxidant activity of plant extract was assessed using DPPH,nitric oxide and H2O2 radical scavenging methods.In vitro anti-inflammatory activity was evaluated using albumin denaturation,membrane stabilization methods at various concentrations.The antibacterial and anti-fungal activity of extracts was also done against micro-organisms:Pseudomonas aurignosa,Escherichia coli,Staphylococcus aureus,Bacillus subtilis and Candida albicans.Quantitative analysis of total phenolics,flavonoids and tannins were also estimated.Female Wistar albino rats(220-260g)were employed and ovaries were surgically removed bilaterally in anaesthesia which causes post-menopausal syndrome in all the groups except sham operated rats.Extracts of Pinus roxburghii stem at 100 and 200mg·kg-1,po.and tamoxifen as standard 1mg·kg-1,po.were given.Acute toxicity study was also done.RESULTS Treatment with Pinus roxburghii extract in two doses significantly(P<0.05)ameliorated surgical ovariectomy induced biochemical and biomechanical changes like decrease in bone density,bone strength,alkaline phosphatase,serum calcium,serum phosphorous and increase in urine hydroxylproline levels.Plant extract also has significant(P<0.05)antioxidant,antimicrobial and anti-inflammatory activities.CONCLUSION The assessments done in present investigation may conclude that the constituents of Pinus roxburghii has significant potential in ameliorating oxidative,inflammatory reactions and possesses anti-microbial;osteobalstic and osteoclastic activities used for calcium homeostatis and improved bone strength in female rats.
文摘A cell is a house to myriad biochemical reactions composed in a symphony of various pathways,both survival and apoptotic.Apoptosis is of fundamental significance to an organ by replacing weary and senile cells with juvenile cells.
文摘Disease management is often complicated by the presence of multiple types of pathogens;in an organic system, it is appropriate to develop disease control strategies. The available literature so far reflects that the management of important disease of tomato is through the integrated approaches and very few organic approaches have been tried with various degree of success. Boiopriming of seeds with biocontrol agents (Trichoderma viridae, Trichoderma harzianum and Pseudomonas fluorescens) in combination with different biofertilizers (Azotobacter, Azospirillum and PSB) and organic manures (FYM and vermi-compost) were tested against disease incidence and health management of tomato seedling under nursery as well as field conditions. The studies were conducted during two successive years (2012-2013) at farmer’s field with the objective to combat with the increasing disease incidence of three major disease damping-off, fusarium wilt and buckeye rot from nursery stage to the final harvesting. The study focused on the use of biocontrol agents as the suitable alternative to chemical pesticides with sustainable disease management without pesticide residues in foodstuff. The bio priming of seeds with fungal antagonist Trichoderma viridae and harzianum and bacterial antagonist Pseudomonas fluorescens significantly improved the germination behavior of tomato seeds as compared to untreated control. Highest mean germination (93.1%) and seedling vigour (953.33) was recorded in Treatment 3 (FYM @ 200 q/ ha + Azospirillum + PSB + Trichoderma herzianum (4 kg/ha each) and lowest in control (60.3%) and (304.83), thus indicating a significant per cent increase in seedling emergence (54.4%) and seedling vigour (95.23%). A considerable reduction in disease incidence (pre and post) of damping off was observed in treatment T? and T? (VC @ 50 q/ha + Azospirillum + PSB + Trichoderma herzianum @ (4 kg/ha) with 45.6% and 35.4% respectively). Treatment T? proved highest in terms of yield (665 Kg/Ha), Hence these diseases can be managed by successful application of Biocontrol agents.
基金The research is funded by Researchers Supporting Program at King Saud University,(Project#RSP-2021/305).
文摘This paper presents a novel application of metaheuristic algorithmsfor solving stochastic programming problems using a recently developed gaining sharing knowledge based optimization (GSK) algorithm. The algorithmis based on human behavior in which people gain and share their knowledgewith others. Different types of stochastic fractional programming problemsare considered in this study. The augmented Lagrangian method (ALM)is used to handle these constrained optimization problems by convertingthem into unconstrained optimization problems. Three examples from theliterature are considered and transformed into their deterministic form usingthe chance-constrained technique. The transformed problems are solved usingGSK algorithm and the results are compared with eight other state-of-the-artmetaheuristic algorithms. The obtained results are also compared with theoptimal global solution and the results quoted in the literature. To investigatethe performance of the GSK algorithm on a real-world problem, a solidstochastic fixed charge transportation problem is examined, in which theparameters of the problem are considered as random variables. The obtainedresults show that the GSK algorithm outperforms other algorithms in termsof convergence, robustness, computational time, and quality of obtainedsolutions.
文摘The field of solid modeling has created numerous techniques for unambiguous computer representations of three-dimensional objects. Its data structures and algorithms have been used in a broad range of applications: Computer-Aided Design and Computer-Aided Manufacturing (CAD/ CAM), robotics, computer vision, computer graphics and visualization, virtual reality, etc. This research paper is used to generate process plan from feature-based modeling, based on an integrated geometric modeling system that supports both feature-based modeling and information storage. Present system is developed only for milling components and limited to selective machining features for prismatic components and further implemented for more machining features to develop algorithms for modeling the components through the input of machining features. As a result, feature information is directly available to downstream activities, and feature extraction is no longer needed. The various systematic steps involved in this approach are study of Design, identification of Features, selection of Processes, Tools and Machines, Machining and Inspection [DFPTMMI]. Machining features generated in the design stage are recognized and stored under the Visual Basic control of CATIA software ActiveX interface. Algorithms are developed for individual features and these algorithms are embedded in Visual Basic forms. This system is discussed and suited for 2.5 Dimensional part approach, however, that can be extended to 3 dimensional prismatic part and complex features machining. Finally a process planning chart has been presented as a model process planning.
文摘After the discovery of hexagonal ferrites or hexaferrites, it has been become important materials commercially and technically to study which is still growing on. In this article, we have reviewed about the M-type hexaferrites including their structural, synthesis techniques and important magnetic properties. The role of experimental synthesizing techniques adopted for preparation of M-type hexaferrites on the various parameters studied in this review paper. The substitution of holonium in BaM ferrite reduces the value of coercivity but not saturation magnetization and ramanence and the cobalt-titanium substituted ferrites were the most important M-type ferrites in the field of application in microwave properties and magnetic field industry.
文摘Sodium potassium niobate (KNN) (K0.5Na0.5NbO3) nanopowder with a mean particle size of about 20 - 30 nm was synthesized by wet chemical route using Nb2O5 as Nb source. A solution of K, Na and Nb cations was prepared, which resulted in a clear gel after the thermal treatment. Phase analysis, microstructure and morphology of the powder were determined by X-ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Field Emission Scanning Electron Microscopy (FESEM). The obtained gel was first analyzed by Thermo Gravimetric Analyzer (TGA) and Differential Scanning Calorimetry (DSC), and then calcined at different temperatures of 400℃, 500℃, 600℃ and 700℃. The X-Ray Diffraction (XRD) patterns of the synthesized samples confirmed the formation of the orthorhombic crystal phase of K0.5Na0.5NbO3 at 500?C, a temperature significantly lower than that typically used in the conventional mixed oxide route. The process developed in this work is convenient to realize the mass production of KNN nanopowders at low cost and suitable for various industrial applications.
文摘MicroRNA-153(miR-153),belongs toa dass of small non-coding RNA.It is a aritical regulator of gene expression at the post-transcriptional lewel which interacts with the functional mRNA at 3UTR rgion and suppresses the expression of the mRNA.More recently,it has become apparent that dhanges in the miR-153 axpression lead to invasion,metastasis,angiogenesis and various types of tumor progression.This review summarizes the connection between dysrgulation of miR-153 and various typas of cancer progression.miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the ancer cell and also show synergistic activity with anticancer drugs.In addition to this,the oncogenic bchavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.
文摘Cloud computing is currently an embryonic domain in the area of information technology that possesses the power of transforming the way information technology (IT) services are delivered and maintained in the business world. Pay as per the usage kind of cost structure coupled with delivery of computing services through internet makes cloud computing an exciting and potential growth oriented information technology model compared with conventional computing services delivery models. Various additional features like scalability, flexibility and easy deployment process creates a window for the organizations even relatively smaller in size to get benefitted by the highly advanced & modern technologies without incurring substantial cost. In spite of so many benefits of this new delivery model, concerns are beginning to grow about how safe an environment it is. Despite of all the hype surrounding the cloud, enterprise customers are still reluctant to deploy their business in the cloud. Security is one of the major issues which reduces the growth of cloud computing and complications with data privacy and data protection continue to plague the market. Other related concerns associated with the adoption of cloud computing include trust on service providers, loss of control and compliance issues. This paper is an attempt to explore security & trust issues linked with cloud computing adoption in the Small and Medium Enterprises (SME) sector.
基金We would like to acknowledge the support by the Department of Biotechnology(DBT),Government of India under its Ramalingaswami Fellowship(BT/RLF/Re-entry/24/2014)Indian Council of Medical Research(ICMR)Adhoc grant(No.5/13/6/2022/NCD-Ⅲ,2021-12187)awarded to Prof.(Dr.)Manoj Garg+1 种基金Aishwarya Singh is highly thankful to the ICMR for providing a junior research fellowship under the guidance of Prof.Manoj GargThe authors wish to acknowledge the DBT/Wellcome Trust India Alliance Fellowship[IA/E/17/1/503663]awarded to Dr.Shinjinee Sengupta for financial support.
文摘The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular homeostasis.The mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating kinases.mTOR signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor signaling.The emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human malignancies.Here,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and autophagy.Additionally,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR signaling.Importantly,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug resistance.Here,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.
基金This research was supported by Brain Pool Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(No.2020H1D3A1A04081409。
文摘Vacancy engineering in metal sulfides has garnered enormous attention from researchers because of their outstanding ability to modulate the optical and physiochemical properties of photocatalysts.Typically,in the case of sulfides,the catalytic activity is drastically hindered by the quick reassembly of excitons and the photocorrosion effect.Hence designing and generating S-vacancies in metal sulfides has emerged as a potential strategy for attaining adequate water splitting to generate H_(2) and O_(2) because of the simulta-neous improvement in the optoelectronic features.However,developing efficient catalysts that manifest optimal photo(electro)catalytic performance for large-scale applicability remains challenging.Therefore,it is of utmost interest to explore the insightful features of creating S-vacancy and study their impact on catalytic performance.This review article aims to comprehensively highlight the roles of S-vacancy in sulfides for amended overall water-splitting activity.The photocatalytic features of S-vacancies modulated metal sulfides are deliberated,followed by various advanced synthetic and characterization techniques for effectual generation and identification of vacancy defects.The specific aspects of S-vacancies in refin-ing the optical absorption range charge carrier dynamics,and photoinduced surface chemical reactions are critically examined for overall water splitting applications.Finally,the vouchsafing outlooks and op-portunities confronting the defect-engineered(S-vacancy)metal sulfides-based photocatalysts have been summarized.
文摘Ovarian cancer is the second most fatal gynecological cancer. For the last decade or so significant use of non-circulating and circulating biomarkers has been highlighted. However, the study of such biomarkers at nanovesicle technology such as exosomes, proteomic and genomics studies could further contribute to better identification of anomalous protein and networks which could act as potential targets for biomarker and immunotherapy development. This review provides an overview of the circulating and non-circulating biomarkers with the aim of addressing the current challenges and potential biomarkers that could lead to early ovarian cancer diagnosis and better management. By means of this review we also lay a hypothesis that characterization of exosomal protein, nucleic acid content from body fluids (serum, plasma, urine, etc.) can decode the secret of disease and potentially improve diagnostic sensitivity which could further lead to more effective screening and early detection of the disease.