Objective:To evaluate the meta-analysis of evaluate the clinical efficacy and safety of insulin deside in improving pregnancy with diabetes,and to conduct a Meta-analysis study on the treatment of pregnancy with diabe...Objective:To evaluate the meta-analysis of evaluate the clinical efficacy and safety of insulin deside in improving pregnancy with diabetes,and to conduct a Meta-analysis study on the treatment of pregnancy with diabetes.Methods:Before this study,we comprehensively and systematically searched the major literature websites at home and abroad.From the establishment of the database to January 9,2022,we searched the Chinese and English literature on the randomized controlled trial(RCT)of insulin detemir in the treatment of pregnancy complicated with diabetes.We screened them in strict accordance with the acceptance criteria.The bias risk assessment tool in Cochrane system evaluator manual 5.1.0 was used to evaluate the quality of the selected literature,and the Review Manager 5.4 software was used for meta-analysis.Results:Finally,24 RCTs target literatures were obtained,with a cumulative sample size of 2,362 cases.The results of meta-analysis showed that the reduction range of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in patients with insulin detemir combined with routine treatment was greater than that in the control group(P<0.05);compared with conventional treatment,the incidence of premature delivery,macrosomia and cesarean section of the diabetes group were lower than those of the control group(P<0.05).Among them,preterm birth(RR=0.44,95%CI[0.28,0.68],P=0.0002),macrosomia(RR=0.35,95%CI[0.21,0.59],P<0.0001),cesarean section(RR=0.82,95%CI[0.72,0.94],P=0.005),fasting blood glucose(SMD=-1.21,95%CI[-1.54,-0.88],P<0.00001),2 h postprandial blood glucose(SMD=-1.63,95%CI[-1.91,-1.35],P<0.00001),glycosylated hemoglobin(SMD=-2.41,95%CI[-3.12,-1.70],P<0.00001).Conclusion:Routine treatment can improve the clinical effect of pregnancy with diabetes.However,there are low limits on the reference level of this study,so this conclusion has some limitations.展开更多
文摘Objective:To evaluate the meta-analysis of evaluate the clinical efficacy and safety of insulin deside in improving pregnancy with diabetes,and to conduct a Meta-analysis study on the treatment of pregnancy with diabetes.Methods:Before this study,we comprehensively and systematically searched the major literature websites at home and abroad.From the establishment of the database to January 9,2022,we searched the Chinese and English literature on the randomized controlled trial(RCT)of insulin detemir in the treatment of pregnancy complicated with diabetes.We screened them in strict accordance with the acceptance criteria.The bias risk assessment tool in Cochrane system evaluator manual 5.1.0 was used to evaluate the quality of the selected literature,and the Review Manager 5.4 software was used for meta-analysis.Results:Finally,24 RCTs target literatures were obtained,with a cumulative sample size of 2,362 cases.The results of meta-analysis showed that the reduction range of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin in patients with insulin detemir combined with routine treatment was greater than that in the control group(P<0.05);compared with conventional treatment,the incidence of premature delivery,macrosomia and cesarean section of the diabetes group were lower than those of the control group(P<0.05).Among them,preterm birth(RR=0.44,95%CI[0.28,0.68],P=0.0002),macrosomia(RR=0.35,95%CI[0.21,0.59],P<0.0001),cesarean section(RR=0.82,95%CI[0.72,0.94],P=0.005),fasting blood glucose(SMD=-1.21,95%CI[-1.54,-0.88],P<0.00001),2 h postprandial blood glucose(SMD=-1.63,95%CI[-1.91,-1.35],P<0.00001),glycosylated hemoglobin(SMD=-2.41,95%CI[-3.12,-1.70],P<0.00001).Conclusion:Routine treatment can improve the clinical effect of pregnancy with diabetes.However,there are low limits on the reference level of this study,so this conclusion has some limitations.
