Eruptive xanthomas in a patient with severe hypertriglyceridemia:A case report

BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific community.CASE SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two weeks.The patient works as a chef and has a diet that frequently includes oily and greasy foods.This case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi community.CONCLUSION The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment.

Effectiveness of flipped classrooms in nursing education: Systematic review and meta-analysis

Background: The flipped classroom has generated considerable interest in nursing education in the last few years, especially in higher education in China. However, research to date has been insufficient to confirm the effectiveness of the flipped classroom approach. Since most of the Chinese studies are published in Chinese journals, they may not be easily accessible to international researchers. Therefore,this meta-analysis aimed to review the effectiveness of a flipped classroom in nursing education both in English and Chinese databases.Objective: The aim of the present study was to identify the robust available evidence about the effectiveness of flipped classrooms in nursing education through a systematic review and meta-analysis.Methods: A systematic search of English databases, including PubMed, EMBASE, Science Director,CINAHL and Google Scholar, and Chinese databases, including Chinese National Knowledge Infrastructure(CNKI), WanFang Data, VIP Information and Chinese Biomedical Literature(CMB), were conducted to identify peer-reviewed studies that met the inclusion criteria. Two reviewers independently performed study identification with Endnote X7 software and used Excel to extract data. The risk of bias in the included studies was assessed with Cochrane Collaboration's risk of bias tool, and a meta-analysis was conducted using RevMan 5.3 software following the guidelines proposed by PRISMA reporting standards with the protocol register No. CRD42016041826.Results: A total of 29 studies were included in systematic review. There was a significant postintervention improvement in academic performance both in knowledge with a pooled random-effects standardized mean difference of 1.13 and skills with a pooled random-effects standardized mean difference(SMD) of 1.68. Students' self-learning abilities were also improved with a pooled random-effects SMD of 1.51 compared with traditional lecture. In the subgroup analysis, we found that the effect sizes had high fidelity in terms of nursing degrees and research settings. There was a high rating of flipped classroom pedagogy from teaching evaluations, study satisfaction, study attitude and improvement in critical thinking and problem-solving skills.Conclusions: These results indicated that a flipped classroom might help nursing students improve in knowledge, skills, attitudes, self-learning, study satisfaction, critical thinking and problem-solving skills.We recommend adopting this approach for nursing education reform. There is a call for robust empirical research and unification of appraisal standards for further support of the effectiveness of the flipped classroom. Furthermore, a meta-regression analysis is also recommended to explore the sources of heterogeneity in included studies.

Behavior and Approximate Entropy of Right-eye Lateralization During Predation in the Music Frog

Brain asymmetry for processing visual information is widespread in animals.However,it is still unknown how the complexity of the underlying neural network activities represents this asymmetrical pattern in the brain.In the present study,we investigated this complexity using the approximate entropy(ApEn)protocol for electroencephalogram(EEG)recordings from the forebrain and midbrain while the music frogs(Nidirana daunchina)attacked prey stimulus.The results showed that(1)more significant prey responses were evoked by the prey stimulus presented in the right visual field than that in the left visual field,consistent with the idea that right-eye preferences for predatory behaviors exist in animals including anurans;(2)in general,the ApEn value of the left hemisphere(especially the left mesencephalon)was greatest under various stimulus conditions,suggesting that visual lateralization could be reflected by the dynamics of underlying neural network activities and that the stable left-hemisphere dominance of EEG ApEn may play an important role in maintaining this brain asymmetry.

Changes in Electroencephalogram Approximate Entropy Reflect Auditory Processing and Functional Complexity in Frogs

Brain systems engage in what are generally considered to be among the most complex forms of information processing. In the present study, we investigated the functional complexity of anuran auditory processing using the approximate entropy（Ap En） protocol for electroencephalogram（EEG） recordings from the forebrain and midbrain while male and female music frogs（Babina daunchina） listened to acoustic stimuli whose biological significance varied. The stimuli used were synthesized white noise（reflecting a novel signal）, conspecific male advertisement calls with either high or low sexual attractiveness（reflecting sexual selection） and silence（reflecting a baseline）. The results showed that 1） Ap En evoked by conspecific calls exceeded Ap En evoked by synthesized white noise in the left mesencephalon indicating this structure plays a critical role in processing acoustic signals with biological significance; 2） Ap En in the mesencephalon was significantly higher than for the telencephalon, consistent with the fact that the anuran midbrain contains a large well-organized auditory nucleus（torus semicircularis） while the forebrain does not; 3） for females Ap En in the mesencephalon was significantly different than that of males, suggesting that males and females process biological stimuli related to mate choice differently.

A review of the research on music therapy in hospice care

Objective:To summarize the research progress of music therapy in hospice care and to provide reference for further research.Methods:A wide range of literatures on music therapy and hospice care at home and abroad were searched and read,and the literature was integrated,judged,analyzed,and summarized.Results:The related research on music therapy in hospice care mainly focused on western developed countries such as Europe and the United States.China is still in the stage of theoretical exploration,lacking qualitative research based on case investigation and empirical research based on data statistics.Conclusions:Music therapy supports the management of symptoms in hospice care,which can meet the diverse needs of patients and their family members including physical,psychological,social,and spiritual.

Mental health is as important as physical health: The degree and influencing factors of self-perceived burden in elderly patients with essential hypertension

目的:本研究旨在探讨中国大陆老年原发性高血压患者自我负担程度及其影响因素。方法:本研究采用横断面调查方法,从中国成都的六家三级医院招募患者。研究选取了451名老年原发性高血压患者作为研究对象,并进行了多元线性回归分析。结果:结果表明老年原发性高血压患者的自我负担分数为中等程度(27.96±6.04)。根据Spearman的r检验,老年高血压患者焦虑、抑郁、服药依从性对自我感觉负担有统计学意义(r=0.372,0.899,0.438,P=0.000)。单因素分析显示,自我感觉负担评分中患者性别、居住地、月人均收入、婚姻状况、是否负担得起医疗费用、并发症数量差异有统计学意义(P<0.05)。多元回归分析也显示焦虑、服药依从性、年龄、婚姻状况是老年高血压患者自我感觉负担的主要影响因素(P<0.05)。结论:我们的护理人员应注意老年高血压患者的自我负担,应提供全方位系统的护理,以减轻他们的自我负担。