A network pharmacology approach to investigate the mechanisms of Si-Jun-Zi decoction in the treatment of gastric precancerous lesions

探讨四君子汤治疗胃癌前病变潜在的作用机制。方法:运用网络药理学分析四君子汤治疗胃癌前病变的活性成分、药物作用靶点及作用通路。通过TCMSP数据筛选四君子汤的活性成分及潜在靶点;通过GeneCards数据库筛选胃癌前病变的疾病靶点。进而对这些靶点进行GO富集和KEGG通路富集分析,从而揭示四君子汤治疗胃癌前病变的作用机制。结果:四君子汤含有111个活性成分,对应胃癌前病变90个靶点。涉及654条GO生物过程与21条信号通路。进而构建出成分-靶点网络、靶点-通路网络及胃癌前病变整合通路,分析结果显示四君子汤主要通过干预胃黏膜炎症、细胞凋亡和增殖过程发挥治疗作用。结论:网络药理学为阐明四君子汤治疗胃癌前病变作用机制提供了新的方法,有助于中医药现代化研究的开展。

Discussing the six meridional diseases of Shanghan Lun based on stress theory

As the theoretical source of Traditional Chinese Medicine clinical medicine,Shanghan Lun plays a vital role in guiding the diagnosis and treatment of clinical diseases.Stress is a systemic nonspecific and adaptive response that occurs when the body is stimulated by internal and external environmental factors.This paper discusses the correlation between the three phases of stress containing alarm,resistance,and exhaustion and the three yin and three yang diseases.It was concluded that sanyang diseases were related to the alarm stage and resistance stage,and sanyin diseases were related to the failure stage.The results indicated the essence of diseases of six meridians from the perspective of stress and provided reference for the diagnosis and treatment of six classics diseases.