Background Currently,the global ageing population is becoming increasingly severe,and the incidence of pelvic organ prolapse(POP)is rising year by year,which seriously impacts the psychosomatic health and the quality ...Background Currently,the global ageing population is becoming increasingly severe,and the incidence of pelvic organ prolapse(POP)is rising year by year,which seriously impacts the psychosomatic health and the quality of life in female patients.Surgical treatments for POP still face enormous challenges.Methods The aim of this review is to discuss the laparoscopic lateral suspension(LLS)approach to the management of POP.We use MeSH terms for each topic to retrieve relevant literature from the PubMed and Embase databases.Our group reviewed,synthesised and summarised included studies.Results LLS has been widely applied in the treatment of middle pelvic compartment defects.In comparison to sacrocolpopexy(SC),the most significant advantage of LLS is that it avoids dissecting the complex sacral region and possesses simple surgical procedures.But its cure,recurrence,reoperation and complication rates have been widely discussed.Issues regarding its value and its potential equivalence in surgical therapeutic effects compared with SC have gained continuous attention.Conclusions Based on the existing research,LLS demonstrates advantages in the treatment of POP,particularly in cases of middle pelvic compartment defects.However,solely based on current clinical studies,it is premature to establish superiority or inferiority compared with SC.LLS is not yet a substitute for SC.展开更多
Anal high-grade squamous intraepithelial lesion(HSIL)refers to the precancerous lesions of anal squamous cell carcinoma(ASCC).Anal cancer is often asymptomatic in its early stage.
Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and function...Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What＇s more,the biomedical application of self-healing hydrogels in vivo was discussed.展开更多
基金supported by the foundation of Science&Technology Department of Sichuan Province(No.2019YFS0008,funder:DW)the National Key Research and Development Program of China(No.2021YFC2009100,funder:XN).
文摘Background Currently,the global ageing population is becoming increasingly severe,and the incidence of pelvic organ prolapse(POP)is rising year by year,which seriously impacts the psychosomatic health and the quality of life in female patients.Surgical treatments for POP still face enormous challenges.Methods The aim of this review is to discuss the laparoscopic lateral suspension(LLS)approach to the management of POP.We use MeSH terms for each topic to retrieve relevant literature from the PubMed and Embase databases.Our group reviewed,synthesised and summarised included studies.Results LLS has been widely applied in the treatment of middle pelvic compartment defects.In comparison to sacrocolpopexy(SC),the most significant advantage of LLS is that it avoids dissecting the complex sacral region and possesses simple surgical procedures.But its cure,recurrence,reoperation and complication rates have been widely discussed.Issues regarding its value and its potential equivalence in surgical therapeutic effects compared with SC have gained continuous attention.Conclusions Based on the existing research,LLS demonstrates advantages in the treatment of POP,particularly in cases of middle pelvic compartment defects.However,solely based on current clinical studies,it is premature to establish superiority or inferiority compared with SC.LLS is not yet a substitute for SC.
基金Beijing Health and Technology Achievement and Appropriate Technology Promotion Project(BHTPP2022008)National Key Research and Development Program(2021YFC2701202)+2 种基金Shanghai Natural Science Foundation General Program(no.22ZR1408800)National Natural Science Foundation General Program(no.82272970)Shanghai Municipal Science and Technology Commission Medical Innovation Research Project(no.21Y11906500).
文摘Anal high-grade squamous intraepithelial lesion(HSIL)refers to the precancerous lesions of anal squamous cell carcinoma(ASCC).Anal cancer is often asymptomatic in its early stage.
基金supported by the National Natural Science Foundation of China(No.31600778)funded by SichuanUniversity(No.2016SCU11044)
文摘Hydrogels are promising materials with outstanding characteristics such as tunable and reversible physical/chemical properties,stimuli-responsiveness,biomimetic,and biocompatibility.However,the structural and functional integrity of the hydrogels can be compromised by external mechanical forces or chemical erosion when used,especially in sophisticated in vivo environment.To address this problem,self-healing hydrogels which possess the intrinsic ability of self-repair have been developed to adapt to destructive factors.In this review,we focused on the current advances made in self-healing hydrogels.First,the testing methods for self-healing hydrogels were summarized.Then,we looked into the designing strategies of self-healing hydrogels and illustrated the self-healing mechanism.What＇s more,the biomedical application of self-healing hydrogels in vivo was discussed.
