Human society is becoming more and more inclusive, diverse, and open-minded, which has led to the increasing recognition of linguistic rights as a basic human right Around the world, many countries have recognized the...Human society is becoming more and more inclusive, diverse, and open-minded, which has led to the increasing recognition of linguistic rights as a basic human right Around the world, many countries have recognized the status of their national sign language at the legal level However, sign languages and their main users, the Deaf, are still facing many challenges At the macro level, sign languages are neglected by mainstream culture, causing them to be endangered At the micro level, communication barriers make it extremely hard for Deaf people to express their demands A series of language plans can be designed to effectively deal with the challenges above, including social language plans, family language plans, and school language plans.展开更多
Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dys...Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dysplastic cells and signet ring cells. The percentages of the three kinds of mucins seen in the two kinds of cells were not much different. It was indicated that the altered mucins in the gastric epithelial cells must be a sign of dedifferentiation of the cells and the results of malfunction. The globoid dysplasia type I mainly contained neutral mucin, whereas type II, the acid mucin was predominant, especially the sulphomucin. The CEA positive reaction became stronger as the atypia being remarkable, and the characteristics of distribution of CEA positive particles were similar in the two kinds of cells namely, randomly or disorderly in the cells. Based on the analysis of the results, a conclusion can be made that the variety of mucins in globoid dysplastic cells can be used as a reference point in classification and is not much significant in grading, but the amount of CEA positive matter can be a reference point in grading. The globoid dysplasia is such a lesion with special features in morphology and function manifested in the process of de-differentiation towards signet ring cell carcinoma following the successive action of carcinogens upon the cells of gastric epithelium.展开更多
OBJECTIVE To establish a small compound library via a versatile synthetic route for the investigation of natural-inspiring compounds containing N-hydroxypyridones motif as potential anti-plasmodial,anti-bacterial and ...OBJECTIVE To establish a small compound library via a versatile synthetic route for the investigation of natural-inspiring compounds containing N-hydroxypyridones motif as potential anti-plasmodial,anti-bacterial and iron(Ⅱ)-chelating agents.METHODS An amidation/cyclization approach was adopted to synthesize a library of N-hydroxyquinolinones.The anti-plasmodial susceptibility of lab clone 3D7 P.falciparum was measured using aprotocol modified from the WHO microtest.The minimum bactericidal concentration(MBC)values were determined against Escherichia coli and Staphylococcus arueus.Nine compounds were selected to test their iron(Ⅱ)-chelating abilities.The iron(Ⅱ)-chelating ability was determined by measuring the absorbance of ferrozine-iron complex at 562 nm.RESULTS A new route for the facile synthesis of a library of N-hydroxyquinolinones based on one-pot palladium catalyzed C-N amidation/dehydrocyclizationsequence was implemented.Four compounds show anti-plasmodial activities with the range of 1.1-1.4μmol·L-1,50% chelation abilities of the nine selected compounds were shown to be 0.24-0.29mmol·L-1.CONCLUSION Alibrary of N-hydroxyquinolinones was synthesized via a novel synthetic route.The anti-plasmodial and anti-bacterial activities of these compounds were evaluated.Four compounds show potent anti-plasmodial activities Nine compounds were examined for their propensities to undergo iron chelation and these compounds were shown to be promising iron(Ⅱ)chelators as compared to EDTA.展开更多
Two ring signals P1, P2 beyond the Uranian ε Ring are detected from noise by statistical method. Applying the time series test and the wave form correlation test to the Beijing data of March 10, 1977 occultation by t...Two ring signals P1, P2 beyond the Uranian ε Ring are detected from noise by statistical method. Applying the time series test and the wave form correlation test to the Beijing data of March 10, 1977 occultation by the Uranus systems, we discovered two ring signals beyond the ε Ring. The method and formulae used and the meaning of the sign are the same as in Ref. [1].展开更多
The objective of this paper was to study low temperature crack resistance mechanism of steel slag asphalt mixture(SAM).Thermal stress restrained specimen test(TSRST)and three-point bending test were carried out to eva...The objective of this paper was to study low temperature crack resistance mechanism of steel slag asphalt mixture(SAM).Thermal stress restrained specimen test(TSRST)and three-point bending test were carried out to evaluate the low-temperature crack resistance of SAM and basalt asphalt mixture(BAM).Based on the digital image correlation technique(DIC),the strain field distribution and crack propagation of SAM were analyzed from the microscopic point of view,and a new index,crack length factor(C),was proposed to evaluate the crack resistance of the asphalt mixture.The crystal phase composition and microstructure of steel slag aggregate(SA)and basalt aggregate(BA)were studied by X-ray diffraction(XRD)and scanning electron microscopy(SEM)to explore the low-temperature crack resistance mechanism of SAM.Results show that the low-temperature crack resistance of SAM is better than that of BAM;SAM has good integrity and persistent elastic deformation,and its bending failure mode is a hysteretic quasi-brittle failure;The SA surface is evenly distributed with pores and has surface roughness.SA has the composition phase of alkaline aggregate-calcite(CaCO3),so it has good adhesion to asphalt,which reveals the mechanism of excellent low-temperature crack resistance of SAM.展开更多
聋童或弱听儿童因为听觉上的障碍,言语输入受阻,以致严重影响他们的口语及书面语的发展。由于言语沟通出现困难,直接影响他们的社交、认知及学习能力。手语语言学研究指出自然手语与口语一样有完整的语法系统。其他相关研究也让我们了...聋童或弱听儿童因为听觉上的障碍,言语输入受阻,以致严重影响他们的口语及书面语的发展。由于言语沟通出现困难,直接影响他们的社交、认知及学习能力。手语语言学研究指出自然手语与口语一样有完整的语法系统。其他相关研究也让我们了解到聋人社群发展的自然手语作为一种视觉语言,对聋童来说,他们可以无障碍地获得,跟健听儿童获得口语一样,毫不费力。近年跨语言渠道双语获得(Bimodal bilingual acquisition)的研究显示:聋、健儿童只要从小同时接触手语和口语这两种语言,他们便可成为有效的跨语言渠道双语用户。手语双语共融教育计划(Sign Bilingualism and Co-enrolment in Deaf Education Programme(SLCO))就是基于以上假设逐步在主流教育环境中发展出来的,以解决香港长久以来聋人教育只注重单一口语教育实务的问题。通过集中介绍SLCO计划的发展概念和推行方式,并且简单介绍计划如何促进聋、健学生的双语发展,更有效达到社交和学术上的融合。展开更多
文摘Human society is becoming more and more inclusive, diverse, and open-minded, which has led to the increasing recognition of linguistic rights as a basic human right Around the world, many countries have recognized the status of their national sign language at the legal level However, sign languages and their main users, the Deaf, are still facing many challenges At the macro level, sign languages are neglected by mainstream culture, causing them to be endangered At the micro level, communication barriers make it extremely hard for Deaf people to express their demands A series of language plans can be designed to effectively deal with the challenges above, including social language plans, family language plans, and school language plans.
文摘Fourty-three cases of globoid dysplasia and signet ring cell carcinoma were stained by mucin and CEA (ABC method). It was found that there were three kinds of mucins (neutral, sialo and sulphomucin in both globoid dysplastic cells and signet ring cells. The percentages of the three kinds of mucins seen in the two kinds of cells were not much different. It was indicated that the altered mucins in the gastric epithelial cells must be a sign of dedifferentiation of the cells and the results of malfunction. The globoid dysplasia type I mainly contained neutral mucin, whereas type II, the acid mucin was predominant, especially the sulphomucin. The CEA positive reaction became stronger as the atypia being remarkable, and the characteristics of distribution of CEA positive particles were similar in the two kinds of cells namely, randomly or disorderly in the cells. Based on the analysis of the results, a conclusion can be made that the variety of mucins in globoid dysplastic cells can be used as a reference point in classification and is not much significant in grading, but the amount of CEA positive matter can be a reference point in grading. The globoid dysplasia is such a lesion with special features in morphology and function manifested in the process of de-differentiation towards signet ring cell carcinoma following the successive action of carcinogens upon the cells of gastric epithelium.
基金The project supported by the Agency for Science Technology and Research(A*STAR)(JCO-10/03/FG/06/02)
文摘OBJECTIVE To establish a small compound library via a versatile synthetic route for the investigation of natural-inspiring compounds containing N-hydroxypyridones motif as potential anti-plasmodial,anti-bacterial and iron(Ⅱ)-chelating agents.METHODS An amidation/cyclization approach was adopted to synthesize a library of N-hydroxyquinolinones.The anti-plasmodial susceptibility of lab clone 3D7 P.falciparum was measured using aprotocol modified from the WHO microtest.The minimum bactericidal concentration(MBC)values were determined against Escherichia coli and Staphylococcus arueus.Nine compounds were selected to test their iron(Ⅱ)-chelating abilities.The iron(Ⅱ)-chelating ability was determined by measuring the absorbance of ferrozine-iron complex at 562 nm.RESULTS A new route for the facile synthesis of a library of N-hydroxyquinolinones based on one-pot palladium catalyzed C-N amidation/dehydrocyclizationsequence was implemented.Four compounds show anti-plasmodial activities with the range of 1.1-1.4μmol·L-1,50% chelation abilities of the nine selected compounds were shown to be 0.24-0.29mmol·L-1.CONCLUSION Alibrary of N-hydroxyquinolinones was synthesized via a novel synthetic route.The anti-plasmodial and anti-bacterial activities of these compounds were evaluated.Four compounds show potent anti-plasmodial activities Nine compounds were examined for their propensities to undergo iron chelation and these compounds were shown to be promising iron(Ⅱ)chelators as compared to EDTA.
文摘Two ring signals P1, P2 beyond the Uranian ε Ring are detected from noise by statistical method. Applying the time series test and the wave form correlation test to the Beijing data of March 10, 1977 occultation by the Uranus systems, we discovered two ring signals beyond the ε Ring. The method and formulae used and the meaning of the sign are the same as in Ref. [1].
基金Funded by the National Natural Science Foundation of China(No.11962024)Key Technology Project of Inner Mongolia Autonomous Region(No.2019GG031)。
文摘The objective of this paper was to study low temperature crack resistance mechanism of steel slag asphalt mixture(SAM).Thermal stress restrained specimen test(TSRST)and three-point bending test were carried out to evaluate the low-temperature crack resistance of SAM and basalt asphalt mixture(BAM).Based on the digital image correlation technique(DIC),the strain field distribution and crack propagation of SAM were analyzed from the microscopic point of view,and a new index,crack length factor(C),was proposed to evaluate the crack resistance of the asphalt mixture.The crystal phase composition and microstructure of steel slag aggregate(SA)and basalt aggregate(BA)were studied by X-ray diffraction(XRD)and scanning electron microscopy(SEM)to explore the low-temperature crack resistance mechanism of SAM.Results show that the low-temperature crack resistance of SAM is better than that of BAM;SAM has good integrity and persistent elastic deformation,and its bending failure mode is a hysteretic quasi-brittle failure;The SA surface is evenly distributed with pores and has surface roughness.SA has the composition phase of alkaline aggregate-calcite(CaCO3),so it has good adhesion to asphalt,which reveals the mechanism of excellent low-temperature crack resistance of SAM.
文摘聋童或弱听儿童因为听觉上的障碍,言语输入受阻,以致严重影响他们的口语及书面语的发展。由于言语沟通出现困难,直接影响他们的社交、认知及学习能力。手语语言学研究指出自然手语与口语一样有完整的语法系统。其他相关研究也让我们了解到聋人社群发展的自然手语作为一种视觉语言,对聋童来说,他们可以无障碍地获得,跟健听儿童获得口语一样,毫不费力。近年跨语言渠道双语获得(Bimodal bilingual acquisition)的研究显示:聋、健儿童只要从小同时接触手语和口语这两种语言,他们便可成为有效的跨语言渠道双语用户。手语双语共融教育计划(Sign Bilingualism and Co-enrolment in Deaf Education Programme(SLCO))就是基于以上假设逐步在主流教育环境中发展出来的,以解决香港长久以来聋人教育只注重单一口语教育实务的问题。通过集中介绍SLCO计划的发展概念和推行方式,并且简单介绍计划如何促进聋、健学生的双语发展,更有效达到社交和学术上的融合。
