Gd-EOB-DTPA-enhanced magnetic resonance imaging for focal liver lesions in Chinese patients:a multicenter,open-label,phase Ⅲ study

BACKGROUND:Contrast agents help to improve visibility in magnetic resonance(MR)imaging.However,owing to the large interstitial spaces of the liver,there is a reduction in the natural contrast gradient between lesions and healthy tissue.This study was undertaken to evaluate the efficacy and safety of the liverspecific MR imaging contrast agent gadoxetate disodium(GdEOB-DTPA)in Chinese patients.METHODS:This was a single-arm,open-label,multicenter study in patients with known or suspected focal liver lesions referred for contrast-enhanced MR imaging.MR imaging was performed in 234 patients before and after a single intravenous bolus of Gd-EOB-DTPA(0.025 mmol/kg body weight).Images were evaluated by clinical study investigators and three independent,blinded radiologists.The primary efficacy endpoint was sensitivity in lesion detection.RESULTS:Gd-EOB-DTPA improved sensitivity in lesion detection by 9.46%compared with pre-contrast imaging for the average of the three blinded readers(94.78%vs 85.32%for Gd-EOB-DTPA vs pre-contrast,respectively).Improvements in detection were more pronounced in lesions less than 1cm.Gd-EOB-DTPA improved diagnostic accuracy in lesion classification.CONCLUSIONS:This open-label study demonstrated that Gd-EOB-DTPA improves diagnostic sensitivity in liver lesions,particularly in those smaller than 1 cm.Gd-EOB-DTPA also significantly improves the diagnostic accuracy in lesion classification,and furthermore,Gd-EOB-DTPA is safe in Chinese patients with liver lesions.

Thermodynamic Behavior Research Analysis of Twin-roll Casting Lead Alloy Strip Process

The thermodynamic behavior of twin-roll casting （TRC） lead alloy strip process directly affects the forming of the lead strip, the quality of the lead strip and the production efficiency. However, there is little research on the thermodynamics of lead alloy strip at home and abroad. The TRC lead process is studied in four parameters： the pouring temperature of molten lead, the depth of molten pool, the roll casting speed, and the rolling thickness of continuous casting. Firstly, the thermodynamic model for TRC lead process is built. Secondly, the thermodynamic behavior of the TRC process is simulated with the use of Fluent. Through the thermodynamics research and analysis, the process parameters of cast rolling lead strip can be obtained： the pouring temperature of molten lead： 360-400 ℃, the depth of molten pool： 250-300 mm, the roll casting speed： 2.5-3 m/min, the rolling thickness： 8-9 mm. Based on the above process parameters, the optimal parameters（the pouring temperature of molten lead： 375-390 ℃, the depth of molten pool： 285-300 mm, the roll casting speed： 2.75-3 m/min, the rolling thickness： 8.5-9 mm） can be gained with the use of the orthogonal experiment. Finally, the engineering test of TRC lead alloy strip is carried out and the test proves the thermodynamic model is scientific, necessary and correct. In this paper, a detailed study on the thermodynamic behavior of lead alloy strip is carried out and the process parameters of lead strip forming are obtained through the research, which provide an effective theoretical guide for TRC lead alloy strip process.

Synthesis of New Multibranch Chromophores with Strong Light-emitting in Solution and in PMMA Film

Three new chromophores with triphenylamine as molecular focal point bearing one, two, or three 4-(n-butyloxystyryl) group(s) at the periphery respectively, (named as T1, T2, and T3) have been synthesized and characterized. It is interesting to find that the fluorescence quantum yield increases from T1 (0.489), to T3 (0.535), and to T2 (0.628) in cyclohexane, meanwhile the lifetime for T3 is shorter than T1 and T2, which is an important characteristic for applications in light emitting diode. Also PMMA (polymethyl methacrylate) film doped with T3 gives stronger fluorescence than T1, and T2. Cyclic voltammetry showed that T3 exhibited lowest oxidation potential of 0.52 V vs SCE, suggesting its better hole-transport property.

Radiotoxicity induced by Auger electron emitters in human osteosarcoma cell line using comet assay

The comet assay (single cell gel electrophoresis assay) was used to evaluate the radiotoxicity of Augerelectron emitters in the human osteosarcoma cell line (HOS-8603). After internal exposure to 67Ga-EDTMP, the sar-coma cell has been injured severely. The comet length was longer along with the increase of dose, the appearance ofcomet tail was different from that with respect to the 60Co γ-ray irradiation. DNA damage of cell was mainly due tothe radiation effect of Auger electrons. The 67Ga may be a therapeutic radionuclide with good prospect for tumortreatment and palliation of bone pain induced by metastasis.

Synthesis and Nonlinear Optical Properties of New Quadrupolar Chromophores

Two new symmetric chromophores: 2, 8-bis-[(2-4′-ethoxy phenyl-5-4′-styryl)-1, 3, 4- oxadiazole] didibenzothiophene (abbreviated as SO-G1) and 2, 8-bis-[(2-4′-ethoxy phenyl-5-4′- styryl)-1, 3, 4-oxadiazole]-N-ethyl carbazole (abbreviated as NO-G1) have been synthesized and characterized. Both chromophores exhibit strong two-photon absorption (TPA) with the cross-sections of 2.99×10-48 and 3.48×10-48 cm4?s?photon-1 in THF and large up-conversion emission, when pumped by Ti:sapphire femto-second laser at 720 nm.

Effects of 24h ultra-marathon on biochemical and hematological parameters

AIM: To analyze detailed changes in hematology and biochemistry tests parameters before and after a longdistance race in ultramarathon runners.METHODS: Blood samples of 11 participants were obtained for standard analysis before, immediately after, two days after and nine days after the 2002 International Ultramarathon 24 h Race and the International Association of Ultrarunners (IAU) Asia 24 h Championship.RESULTS: Total bilirubin (BIL-T), direct bilirubin (BIL-D),alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) increased statistically significantly(P<0.05) the race. Significant declines (P<0.05) in red blood cell (RBC), hemoglobin (Hb) and hematocrit (Hct)were detected two days and nine days d after the race.2 d after the race, total protein (TP), concentration of albumin and globulin decreased significantly. While BIL, BIL-D and ALP recovered to their original levels. High-density lipoprotein cholesterol (HDL-C) remained unchanged immediately after the race, but it was significantly decreased on the second and ninth days after the race.CONCLUSION: Ultra-marathon running is associated with a wide range of significant changes in hematological parameters, several of which are injury related. To provide appropriate health care and intervention, the man who receives athletes on high frequent training program high intensity training programs must monitor their liver and gallbladder function.

Studies on apoptosis in bone tumor cells induced by ^(153)Sm

The apoptosis in human bone tumor cells induced by internal irradiation with 153Sm was studied. The morphological changes in bone tumor cells were observed by electronic and fluorescent microscopy, as well as DNA agarose gel eletrophoresis. DNA chain fragmentation, microautoradiographic tracing and the inhibition rate of prolif- eration in bone tumor cells exposed to 153Sm with different duration time were examined. It was demonstrated that the bone tumor cells exposed to 153Sm displayed nuclear fragmentation, pyknosis, margination of condensed chroma- tin, and formation of membrane bounded apoptotic bodies, whereas the percentage of DNA chain fragmentation of bone tumor cells increases in direct proportion to the duration of irradiation with153 Sm, as well as DNA ladder for- mation in apoptotic cells. Also a marked inhibition effect of proliferation in bone tumor cells after exposure with 153Sm was observed.

^(125)I-interleukin-8 radiolabelling and in vivo distribution

To study the radioiodinating condition of interleukin-8(IL-8) and observe its biodistribution in mice for understanding the possibility of its application in nuclear medicine, we labelled IL-8 with 125I using Bolton-Hunter reagent, and the distributions in mice at 5 min, 30 min, 1h, 6h and 24h after injection of 125I –IL-8 were measured. The blood clearance curve was obtained and fitted with the two-compartment model. The results showed that 125I-IL-8 was obtained with a labeling efficiency of 12.2% ±6.5% and a radiochemical purity of 91.4%±6.5%. Its spe- cific activity was 14.8 kBq/μg IL-8. A fast phase half – life T1/2 of 0.32 h and a slow phase half – life T1/2 of 8.01 h α β were calculated from the blood clearance curve. The uptakes of radioactivities in kidneys and lung had the peaks of 85.87%ID /g and 16.17%ID /g at 30 min after intravenous injection, respectively. The uptakes in liver and spleen were 12.05%ID /g and 8.97%ID /g as the maximum at 5 min after injection. The clearance in blood and other organs was fast. Except for kidneys and lung, 125I –IL-8 was less than 1%ID/ g 24 h after administration. It is concluded that radioiodinated IL-8 is a promising radiopharmaceutical in nuclear medicine, especially for imaging infection. But to enhance the labeling efficiency of radioiodinated IL-8 and to decrease its in vivo deiodination are the subjects neces- sary to be further investigated.

Synthesis of New Naphthaline-type Chromophores with Strong Green-emitting or the Blue-emitting in β-Cyclodextrin

Three new naphthaline-type chromophores end-capped with different (p-substituted amino) styryl groups on the both sides (named as BPASN, BHMASN and BMASN) have been synthesized. Under excitation of 380 nm, strong green light-emitting locating at 517 nm with the fluorescence quantum yield of 0.88 in CH2Cl2 has been obtained. In the presence of b-cyclodextrin (b-CD), strong blue-emitting at 456 nm in DMF was also recorded.

Failure Characteristic of Laser Cladding Samples on Repeated Impact

Using self-made impact fatigue test instruments and related analytic devices,the mechanical components with laser cladding layer have been attempted. It is found that, onrepeated impact force, several failure modes of the components include the surface cracks, surfaceplastic deformation, corrosive pitting and coat collapse, etc. The paper reported the test methodand initial analysis conclusions about the unique failure characteristics of the mechanicalcomponents on repeated impact load.

The effect of pitch and collimation on radiation dose in spiral CT

Measurements of radiation dose to patients in spiral computed tomography (CT) were completed for various collimations,table speeds and pitch. A standard CT head dosimetry phantom and thermoluminescent dosime- ters (TLD) were used for the measurement. The effect of collimation and pitch on radiation dose was studied. The results indicated that the radiation dose at the given tube current,voltage and rotation speed was inversely propor- tional to pitch. And the increasing times of dose were as decreasing times of pitch. This regular pattern was tenable for radiation dose at both central holes and peripheral holes of the phantom at pitch = 1,>1 and <1. The collimation had no impact on the radiation dose. The results also indicated that radiation dose at central holes was nearly equal to that at peripheral holes. There was no significant difference between them statistically. The study demonstrates that the pitch in spiral CT scans is the primary parameter and has significant impact on radiation dose.

Biological characteristics of tumor apoptotic cells—plused—dendritic cells induced by tumor lysates supernatants

AIM：To prepare the effcient tumor-DC vaccines,dendritic cells(DC) derived from 6-8 weeks Balb/c mice bone marrow progenitor cells were pulsed by apoptotic SP2/0 tumor cells and induced maturation by SP2/0 tumor lysates supermatants. Then SP2/0 tumor burdening Balb/c mice were immunized by the tumor-DC vaccines to observe the therapeutic effects in vivo.METHODS:Immature DC were derived by recombinant murine GMCSF and IL-4,then were pulsed by SP2/0 apoptotic cells. Tumor-DC vaccines were stimulated by LPS and SP2/0 tumor lysates supernatants by four cycles repetitive freezing and thawing,respectively. [^3H]-thymidine incorporation test and standard 4h [^51Cr] release assay were used to detect the proliferation and activation of cytotoxic T lymphocytes (CTL) stimulated by DC in vitro.(4-5)×10^5 DC were immunized in the right inguen of SP2/0 tumor burdening Balb/c mice and most mice received three cycles immunization every two weeks. Changes of the tumor and mice lifespans were recorded .RESULTS:In vitro proliferation and activation of CTL induced by the tumor-DC vaccines of tumor lysates supernatants or LPS stimulation group were more powerful than other groups (P<0.05). According to the regression of tumor and the life-spans of tumor burdening mice,therapeutic effects of tumor lysates supernatants stimulation group were the best, compared with other groups(P<0.05).CONCLUSION:Tumor-DC vaccines,pulsed by apoptotic SP2/0 tumor cells and induced maturation by tumor lysates supernatants,could activate the efficient tumor specific immunity and prolong the life-span of tumor burdening mice.

A Simplified Database-Oriented Web Framework

The paper firstly analyses disadvantages in the traditional Web database systems. And then it puts forward a simplified framework called database-oriented Web framework (DOWF). In this framework, the pages and the data are all managed by database system. In order to get keywords or search a special page, which the users accessed before, users access the static pages by common script procedure (CSP), and access the dynamic pages by functional script procedure (FSP) and CSP. The article expounds the method how to implement DOWF in details. The paper also analyses the mechanism of a DOWF site by implementing a prototype system. At last, the article gives the features of DOWS in search, in security, in reuse of pages and in offline waiting, etc. Key words database-oriented - Web framework - common script procedure (CSP) - functional script procedure (FSP) CLC number TP 391 Foundation item: Supported by Natural Science Foundation of Jiangsu Province (BK2003030).Biography: ZHU Qiao-ming (1963-), male, professor, research direction: Web information processing chinses information processing.

基于图网络和优化算法的晶体结构预测方法的比较

本文结合数据库、图神经网络和优化算法,构成了预测晶体结构的一种高效方法.考虑到数据库、图网络架构以及优化算法众多的可选方案,我们需要建立一个基准测试方法,用以评估这些不同方法在性能上的差异.在本研究中,我们从材料数据库中筛选了100种晶体结构,并建立了一个名为TBCSP的晶体结构预测基准测试,旨在迅速且准确地评估各种晶体结构预测方法的有效性.研究表明,通过结合Materials Project数据库、M3GNet架构和贝叶斯优化算法,可以达到高达40%的预测精度.考虑到训练数据的有限性以及元素和晶体结构的多样性,这一发现为通过适度扩充训练数据以进一步提升准确性展示了一条充满希望的路径.

Heterometallic Mg-Ni-Mg Complex Promoted Hydrosilylation of Alkenes: Catalytic Performance and Intermediates Characterization

Background and Originality Content The catalytic hydrosilylation of unsaturated hydrocarbons,facilitated by transition metal(TM),is widely recognized as a proficient technique for the synthesis of high-value organosilicon compounds'ti-4l over the past few decades,the most dominant cata.lysts in hydrosilylation processes have been constituted by pre-Ccious metar complexesroceinerecent vears omore sustainabile earth-abundant metal catalysts have received increased attentionj2-14l The classcal mechanism of transition metal-catalyzed hydrosilylation is generally accomplished through a series of fundamental processes(Scheme 1a),including(i)coordination and oxidative addition of Si-H bond to a low-valent metal center to form e.g.,o-complex or silyl metal hydride;(ii)insertion of.C-C multipe bonds intometal-hdridelsior metal-silicon bond;jiol and(ii)reductive elimination that forwards the hydrosilylated product with Markovnikov or anti-Markovnikov selectivity.

Continuous Synthesis of Main-Chain-type Fluorinated Graft Copolymers via Successive Flow START Polymerization and Cu(0)-Mediated RDRP

Fluorinated polymers are receiving more and more attention worldwide due to their unique chemical properties,and modified fluorinated polymers with different topologies are persued for enriching and enhancing their performance in a variety of application fields.In this work,main-chain-type semifluorinated graft copolymers are produced steadily in continuous tube reactors via photocontrolled step transferaddition and radical-termination(START)polymerization and Cu(0)-mediated reversible deactivation radical polymerization(Cu(0)-RDRP)at room temperature for the first time.Specifically,semifluorinated alternating copolymer(AB)n B is prepared by START polymerization of 1,6-diiodoperfluorohexane(A)and 1,7-octadiene(B)in the first quartz pipeline under irradiation with purple LED light at 20℃.The(AB)nB with periodic C―I bonds is then flowed into the second copper pipeline directly and acts as the macroinitiators for Cu(0)-RDRP of methyl acrylate(MA)to obtain corresponding graft copolymer(AB)n B-g-PMA.This work provides a new strategy for continuous synthesis of fluorinated graft copolymer materials.

YME1L overexpression exerts pro-tumorigenic activity in glioma by promoting Gai1 expression and Akt activation

DearEditor,Identifying novel glioma-driven signaling molecules and exploring the corresponding molecularly targeted therapies are essential for better and effcient glioma therapy.YME1L(YME1 Like 1 ATPase),a primary member of the AAA family of ATPase,is located at the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L is essential for maintaining mitochondrial morphology,function,and plasticity(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).YME1L assembles into a homo-oligomeric complex within the inner mitochondrial membrane(Anand et al.,2014;MacVicar et al.,2019;Ohba et al.,2020).Moreover,YME1L can degrade mitochondrial proteins,including lipid-transferring proteins,IM translocation proteins.

Search for hidden-charm tetraquark with strangeness in e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.

We report a search for a heavier partner of the recently observed Z_(cs)(3985)^(-) state,denoted as Z_(cs)^('-),in the process e^(+)e^(−)→K^(+)D_(s)^(∗−) D^(∗0 )+ c.c.,based on e^(*)e^(-)collision data collected at the center-of-mass energies of √s=4.661,4.682 and 4.699 GeV with the BESIII detector.The Z_(cs)^('-) is of interest as it is expected to be a candidate for a hidden-charm and open-strange tetraquark.A partial-reconstruction technique is used to isolate K^(+)recoil-mass spectra,which are probed for a potential contribution from Z_(cs)^('-)→D_(s)^(∗−) D^(∗0 )+ c.c.We find an excess of Z_(cs)^('-)→D_(s)^(*-)-D^(*0)(c.c.)candidates with a significance of 2.1o,after considering systematic uncertainties,at a mass of(4123.5±0.7_(sat)±4.7_(syst.))MeV/c^(2).As the data set is limited in size,the upper limits are evaluated at the 90%confidence level on the product of the Born cross sections(σ^(Borm))and the branching fraction(B)of Z_(cs)^('-)→D_(s)^(*-)-D^(*0),under different assumptions of the Z_(cs)^('-) mass from 4.120 to 4.140 MeV and of the width from 10 to 50 MeV at the three center-of-mass energies.The upper limits of σ^(Born).B are found to be at the level of O(1)pb at each energy.Larger data samples are needed to confirm the Z_(cs)^('-) state and clarify its nature in the coming years.

Nanoscale ultraviolet photodetectors based on one- dimensional metal oxide nanostructures

Among the important optoelectronic devices, ultraviolet （UV） photodetectors show wide applications in fire monitoring, biological analysis, environmental sensors, space exploration, and UV irradiation detections. Research interest has focused on the utilization of one-dimensional （1D） metal oxide nanostructures to build advanced UV photodetectors through various processes. With large surface-to-volume ratio and well-controlled morphology and composition, 1D metal oxide nanostructures are regarded as promising candidates as components for building photodetectors with excellent sensitivity, superior quantum efficiency, and fast response speed. This article reviews the latest achievements with 1D metal oxide nanostructures reported over the past five years and their applications in UV light detection. It begins with an introduction of 1D metal oxide nanostructures, and the significance, key parameters and types of photo- detectors. Then we present several kinds of widely-studied 1D nanostructures and their photodetection performance, focusing on binary oxides with wide- bandgap （such as ZnO, SnO2, Ga203, Nb2Os, and WO3） and ternary oxides （such as Zn2SnO4, Zn2GeO4, and In2Ge2OT）. Finally, the review concludes with our perspectives and outlook on future research directions in this field.