在 IRS-2 G1057D 多型性和胃的癌症的风险之间的协会

AIM: To investigate the relationship between insulin receptor substrate-2 (IRS-2) G1057D polymorphism and the risk of gastric cancer (GC) in a Chinese population. METHODS: A case-control study with 197 GC patients and 156 age- and sex-matched control subjects was conducted. The genotypes of polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The genotype frequencies of IRS-2 G1057D polymorphism in cases were obviously different from those in the control group (P = 0.031). Compared with GG genotype carriers, the risk for GC was significantly higher (adjusted odds ratio = 2.32, 95% CI: 1.03-5.23, P = 0.042) in the individuals with the IRS-2 DD geno-type. Furthermore, stratified analysis was performed based on age, sex, smoking status and residence, but no significant difference between the two groups was found. In addition, no significant association between genotypes and clinicopathological features was observed either. CONCLUSION: This study demonstrates that IRS-2 G1057D is involved in susceptibility to GC, although further large-sample studies are still needed.

The effect of neuropeptides on proliferation of rat bone marrow mesenchymal stem cells

Objective To investigate the effects and mechanism of calcitonin gene-related peptide(CGRP)and substance P (SP) on proliferation of rat bone marrow mesenchymal stem cells.Methods The rBMSCs were isolated using whole bone marrow

Experimental study of the effect of adipose stromal vascular fraction cells on the survival rate of fat transplantation

Objective To investigate the effect of adipose stromal vascular fraction cells(SVFs)on the survival rate of fat ransplantation.Methods 0.5mL autologous fat tissue was mixed with: ① DiI-labeled autologous SVFs (Group A);②

Discussion of rationality of radiosurgery therapy on pineal region germ cell tumors

Objective To discuss rationality of stereotaxic radiosurgery as the first therapy strategy on pineal region germ cell tumors. Methods To retrospectively analyze the clinical materials of 14cases which received the treatment of gamma knife or X-knife. The condition of tumor changing ,recurrence

Clinical analysis of squamous cell carcinoma of renal pelvis

Objective To review the diagnosis and treatment of squamous cell carcinoma of renal pelvis. Methods The clinical data,from October 1991 to May 2009,of eight cases of squamous cell carcinoma of renal

Diagnosis and treatment of primary embryonal carcinoma in pineal region:report of two cases and literatures review

Objective Primary embryonal carcinoma in pineal region is extremely rare.Here we report two such cases and combining with literatures review to discuss its diagnosis,treatment and prognosis.Methods Two primary embryonal carcinoma in pineal region verified histologically were presented. In one case,the preoperative serum alpha-fetoprotein (AFP) level reached significantly high level,6

Effect of Botubinum toxin type A injection into the masseter muscle on mandibular development in rats

Objective To investigate the effect of Botulinum toxin type A(Botox)injection into the masseter muscle on mandibular development in rats.Methods 1228-day-old Wistar rats were divided into two groups as Botox group(n=6)and control group(n=6)

Migration of distal catheter of ventriculoperitoneal shunt into heart:report of 2 cases and review of literature

Objective To discuss the mechanism,clinical features,complications,diagnosis criteria and treatment of intracardiac migration of the distal catheter of ventriculoperitoneal shunt. Methods The diagnosis criteria and treatment of 2 cases of intracardiac migration of the distal catheter of

Degradability of absorbable sutures in tendon grafts following anterior cruciate ligament reconstruction

Objective To observe the degradability of absorbable sutures in tendon grafts and the histology of tendon healing in a rabbit model.Methods Semitendinosus tendons were harvested from 15 healthy adult New Zealand rabbits in this study.

A research on invasion of different types of meningeomas to their surrounding tissue

Objective To explore the invasion of different types of meningeoma to their surrounding tissue. Methods The specimen from 124 patients with meningeomas,who underwent surgery in Southern Hospital from April 2009 to June 2010 were used to analyze the invasion of different types of meningeomas to their surrounding tissue. All the tumors were resected in the standard of Simposon I. We referred to WHO 2007

Discussion of diagnosis and therapy strategy for pineal region tumors

Objective To define optimal diagnosis and theraputic strategy of pineal region tumors. Methods Clinicalmaterials of 154 cases with pineal region tumors were analyzed retrospectively. Results The patients with pineal region tumors often complained of increased intracranial pressure and ocular movement deficiency.

Microsurgical anatomy of the ambient cistern and its related arachnoidal membranes

Objective To study microanatomy features and clinical significance of ambient cisterns and their arachnoidal membranes in detail. Methods Ambient cisterns including their shapes,borders,contents and arachnoidal membranes were observed in 20 cadaveric brains using an operating microscope. Results The

Distribution and pheotype changes of macrophage in infantile hemangioma

Objective To observe distribution and phenotypc changes of macrophage in infantile hemangioma. Methods Forty - three infantile hemangioma samples were harvested from resection operation,Distribution and phenolype changes of macrophages labelled with CD68,

A study of making use of computer-aided projection fringe system to measure breast dimension

To measure breast basic dimension by using computer-aided projection fringe system.Methods A system has been developed for measuring breast basic dimension based on computer-aided projection fringe measurement and programming software.Plastic manikins breast’s SN-N (sternal notch to nipple distance),N-ML (nipple to midline distance),N-N (internipple distance),MBW (base width of breast) and N-IMF (nipple to inframammary fold distance) are measured with this system.At the same time,these items are also measured with routine ruler.Results This study indicate that the system has some merits:① non-touching measurement;② it is very rapid,the patient measured need hold his breath only 0.5 second,and all the time it takes is about 2.5 minutes;③ the measurement’s sensitivity is as high as to 0.6 mm,which meets the clinic requirement entirely;④ the measurement’s accuracy of the system is not significantly when comparing to the routine ruler’s.Conclusion Computer-adided projection fringe system for measuring breast basic dimension is feasible and advanced.14 refs,1 fig.

Advances and disputes of posterior malleolus fracture

Objective The objective of this article is to summarize the development of evaluation and treatment of posterior malleolus fracture （PMF）. Data sources Data used in this Study selection Articles were review were mainly from English literature of PubMed data base. ncluded in this review if they were related to the PMF or trimalleolar fracture.

Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair

Background Thoracic endovascular aortic repair （TEVAR） is an emerging treatment moaality, wnicn nas been rapidly embraced by clinicians treating thoracic aortic disease. However, the clinical manifestations of systemic inflammatory response after TEVAR as post-implantation syndrome （PIS） resemble the perioperative infection. This study aimed to evaluate changes and diagnostic value of procalcitonin （PCT） and other traditional inflammatory markers for infections after TEVAR. Methods We conducted a prospective clinical study that enrolled 162 consecutive aortic dissection cases. who underwent TEVAR in our institution between July 2011 and November 2012. The PCT, C-response protein （CRP）, erythrocyte sedimentation rate （ESR） and blood routine examination were monitored before the operation and on days 1, 2, 3 and 5 after the operation. The diagnosis of infection was confirmed by the infection control committee with reference to Hospital Acquired Infection Diagnostic Criteria Assessment, released by the Ministry of Health of the People＇s Republic of China. Results Post endovascular repair of thoracic aorta, PCT changes significantly at different time points （X^2= 13.225, P=0.021）, without significant difference between the PIS group and the control group （0.24±0.04 vs.0.26±0.10, P=0.804）. PCT values were significantly higher in the first day after TEVAR than the preoperative levels （0.18±0.03 vs. 0.11±0.02, P 〈0.001）. Compared with PIS patients, the level of PCT, CRP, White blood cell （WBC） and neutrophil （NEU） in the infection patients elevated significantly （relatively X2=6.062, P=0.048; X2=6.081, P=0.048; X2=11.030, P=0.004; X2=14.632, P=0.001）. According to the ROC analysis, the PCT levels in the first day after TEVAR （AUC=0.785, P=0.012） had better predictive values of infection than WBC, NEU CRP and ESR （AUC=0.720, P=0.040; AUC=0.715, P=0.045; AUC=0.663, P=0.274; AUC=0.502, P=0.991）. The best predictive index was the changes of PCT between preoperative and postoperative （PCT）, which possess AUC as 0.803 （P=0.014）. And PCT=0.055 could be considered as an infection diagnosis cutoff value with a sensitivity of 83.3% and specificity 69.0%.

Effect of superior retinacular artery damage on osteonecrosis of the femoral head

Background Osteonecrosis of the femoral head （ONFH） is the result of dysfunctional blood supply, but associations between specific damaged arteries, imaging changes and clinical sign require more understanding. We investigated characteristics of ONFH that pertain to blood supply, imaging appearance, and clinical feature to judge the prognosis of ONFH.

The Chinese Expert Consensus on Evaluation of Coma after Cardiopulmonary Resuscitation

INTRODUCTIONThe prognosis of patients who suffer from coma after cardiopulmonary resuscitation （CPR） may be poor （defined as cerebral performance categories scores from 3 to 5） Thus, an accurate prediction of their neurological outcomes is an essential component of post-cardiac arrest evaluation, especially for decisions to limit or withdraw life-sustaining care. Since the 1960s, a series of domestic and foreign studies began to focus on the evaluation of coma patients after CPR, and considerable progress has been achieved in this field.