To the Editor:Psoriasis is a chronic immune-related inflammatory skin disease.The clinical severity of psoriasis varies greatly,and recurrence occurs frequently.[1]Many attempts have been made to identify biomarkers f...To the Editor:Psoriasis is a chronic immune-related inflammatory skin disease.The clinical severity of psoriasis varies greatly,and recurrence occurs frequently.[1]Many attempts have been made to identify biomarkers for psoriasis;however,there are currently no specific markers that can accurately monitor disease severity and treatment efficacy.Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that are highly stable and resistant to RNase R since they can form covalently closed loops without 50 caps and 30 tails.[2]It has been reported that circRNAs could exist in body fluids,such as serum and plasma,and could serve as molecular biomarkers in the diagnosis and prognosis of several diseases.[3]In this study,we detected the alteration of circRNAs and investigated the potential value of hsa_circ_0056856 as a biomarker for disease severity in serum samples from psoriasis patients and healthy controls(HCs).展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.81773316 and 82002120)the National Science Foundation of Chongqing,China(No.cstc2021jcyj-msxmX0140).
文摘To the Editor:Psoriasis is a chronic immune-related inflammatory skin disease.The clinical severity of psoriasis varies greatly,and recurrence occurs frequently.[1]Many attempts have been made to identify biomarkers for psoriasis;however,there are currently no specific markers that can accurately monitor disease severity and treatment efficacy.Circular RNAs(circRNAs)are a novel class of endogenous noncoding RNAs that are highly stable and resistant to RNase R since they can form covalently closed loops without 50 caps and 30 tails.[2]It has been reported that circRNAs could exist in body fluids,such as serum and plasma,and could serve as molecular biomarkers in the diagnosis and prognosis of several diseases.[3]In this study,we detected the alteration of circRNAs and investigated the potential value of hsa_circ_0056856 as a biomarker for disease severity in serum samples from psoriasis patients and healthy controls(HCs).
