Clinical and laboratory features compared between JAK2 exon12 and JAK2 V617F mutated polycythemia vera

Objective To compare clinical and laboratory features between JAK2 exon12 and JAK2 V617F mutated polycythemia vera (PV).Method We collected data from 570 consecutive newly-diagnosed subjects with PV and JAK2 mutation, and compared clinical and laboratory features between patients with JAK2 exon12 and JAK2V617F mutation.Results543 (95.3%) subjects harboured JAK2 V617F mutation (JAK2 V617F cohort).

Analysis of the efficacy and prognosis on first-line autologous hematopoietic stem cell transplantation of patients with multiple myeloma

Objective To explore the efficacy and prognosis of first-line autologous hematopoietic stem cell transplantation(ASCT) for newly diagnosed patients with multiple myeloma(MM).Methods From January 2005

Preparation of a novel tri-specific T cell engager targeting CD19 antigen and its anti-leukemia effect exploration

Objective To prepare a novel tri-specific T cell engager(19TriTE)targeting CD19 antigen,and to investigate its immunotherapeutic effect on CD19-positive hematological malignancies.Methods 19TriTE was construeted by molecular cloning technology and successfully expressed through the eukaryotic expressing system.

Congenital factor XI deficiency:a retrospective analysis of 80 cases

Objective To analyze the clinical manifestation,laboratory examination,treatment and prognosis of congenital factor XI(F XI)deficiency.Methods The clinical data of 80 patients with congenital FXI deficiency in our hospital from September 2006 to October 2020 weres analyzed retrospectively.

Effect of iron deficiency level on oral iron absorption

Objective To study the effect of iron deficiency level for oral iron absorption in iron deficient patients.Methods 37 non-pregnant female patients who were diagnosed with iron deficiency and 13 healthy females who completed their physical examination at the outpatient department of the Anemia Center of the Institute of Hematology&Blood Diseases Hospital from July 2018 to June 2020 were included.

Characteristics and prognosis in adult patients with early T-cell precursor acute lymphoblastic leukemia

Objective To analyze the clinical, laboratory characteristics and prognosis of adult early T-cell precursor acute lymphoblastic leukemia (EiTP-ALL). Methods The clinical data of 13 adult (ETP-ALL) patients from January 2009 to March 2017 were retrospectively analyzed and compared with non-ETP ALL patients.

Efficacy of basiliximab in the treatment of 87 cases of steroid-refractory or steroid-dependent acute graft-versus-host disease

Objective To evaluate the efficacy and prognosis of basiliximab in the treatment of steroid-refractory or steroid-dependent acute graft-versus-host disease (SR/SDaGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).Methods Clinical data of 87patients with SR/SD-aGVHD in the skin, intestine, and liver after allo-HSCT at the Institute of Hematology&Blood Diseases Hospital Transplantation Center from January 2015 to December 2018 were retrospectively analyzed.

Congenital factor X deficiency:a retro⁃spective analysis of 11 cases

Objective To analyze the clinical characteristics,laboratory examination, diagnosis, treatment, and outcome of hereditary factorⅩ(FⅩ) deficiency.Methods Clinical data of 11 patients with congenital FⅩdeficiency were retrospectively analyzed from July 2009 to February 2021.Results There were 3 males and 8 females.Median age was 39 (5-55) years. The median duration of follow-up was 81.67 (1.87-142.73) months.

Characteristics of bone marrow compensatory erythropoiesis in hereditary spherocytosis

Objective To reveal the compensatory features of bone marrow (BM) erythropoiesis in hereditary spherocytosis (HS) and to explore the effect of diferent hemoglobin levels on this compensation.Methods Clinical and laboratory data of patients with HS were collected,and the peripheral blood absolute reticulocytes counts value was taken as the surrogate parameter to evaluate the ability of erythropoiesis compensation.

Allo-HSCT for acute myeloid leukemia with myelodysplastic-related changes:a clinical analysis

Objective To evaluate the outcomes and prognostic factors of adults with acute myeloid leukemia with myelodysplastic-related changes(AML-MRC)who received allogeneic hematopoietic stem cell transplantation(allo-HSCT).The genetic mutation lineage of patients with AML-MRC and the molecular mutation affecting the transplantation prognosis was discussed.