Clinical characteristics and CT findings of Pneumocystis Jirovecii pneumonia in 46 cases with hematological diseases

Objective To summarize the original CT features of Pneumocystis Jirovecii pneumonia in patients with hematological diseases.Methods A retrospective analysis was carried out in 46 patients with proven pneumocystis pneumonia(PJP) in the Hospital of Hematology,Chinese Academy of Medical Sciences between January 2014 and December 2021.

Clinical analysis of 14 patients aged ≤ 50 years with high-risk multiple myeloma treated with allogeneic hematopoietic stem cell transplantation

Objective To evaluate the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in young patients with high-risk multiple myeloma(HRMM)and analyze the factors affecting patient prognosis.Methods In this retrospective study,we analyzed the clinical data of 14 patients with HRMM with cytogenetic abnormalities or high-risk biological factors who underwent allo-HSCT at the Hematopoietic Stem Cell Transplantation Center of the Institute of Hematology&Blood Diseases Hospital between November 2016 and November 2022.

Metagenomic next-generation sequencing of plasma for the identification of bloodstream infectious pathogens in severe aplastic anemia

Objective To analyze the diagnostic value of cellfree plasma metagenomic next-generation sequencing(mNGS)pathogen identification for severe aplastic anemia(SAA)bloodstream infection.Methods From February 2021 to February 2022,mNGS and conventional detection methods(blood culture,etc.)were used to detect 33 samples from 29 consecutive AA patients admitted to the Anemia Diagnosis and Treatment Center of the Hematology Hospital of the Chinese Academy of Medical Sciences to assess the diagnostic consistency of mNGS and conventional detection,as well as the impact on clinical treatment benefits and clinical accuracy.

Efficacy and safety of allogeneic hematopoietic stem cell transplantation in the treatment of 28 patients with hepatitis-related aplastic anemia

Objective To evaluate the efficacy and safety of HLAhaploidentical hematopoietic stem cell transplantation(alloHSCT)for hepatitis-related aplastic anemia(HRAA)patients.Methods Retrospective analysis was performed on hepatitis-associated aplastic anemia patients who received haplo-HSCT at our center between January 2012and June 2022.October 30,2022 was the final date of follow-up.Results This study included 28 HRAA patients receiving allo-HSCT。

Clinical characteristics and prognostic factors of patients with Philadelphia-negative myeloproliferative neoplasm accelerated/blast phase

Objective To evaluate the clinical characteristics and prognostic factors of patients with Philadelphianegative myeloproliferative neoplasm-accelerated phase/blast phase(MPN-AP/BP).Methods A total of 67patients with MPN-AP/BP were enrolled from February2014 to December 2021 at the Institute of Hematology and Blood Diseases Hospital,Chinese Academy of Medical Sciences.Their clinical features and prognostic factors were analyzed retrospectively.

Role of IFN-γ+874 genetic polymorphisms in allogeneic hematopoietic stem cell transplantation

Objective To explore the impact of IFN-γ+874 polymorphisms on the outcome in HLA matched sibling HSCT. Methods We used PCR-sequence-specific primer analysis(PCR-SSP) to analyze the polymorphisms of IFN-γ+874 T/A in 80 recipient and donor pairs

Relationship between polymorphisms of tumor necrosis factor alpha gene and primary myelodysplastic syndromes

Objective To investigate the association of single nucleus polymorphisms (SNP) of tumor necrosis factor alpha (TNF-α) gene (-308 G】A and-238 G】A genotypes) with susceptibility to primary myelodysplastic syndromes (MDS) .Methods Two SNPs (TNF-α-308 G】A、TNF-α-238 G】A) of TNF-αgene were detected by Taqman probes in 341 MDS patients and 365 unrelatedhealthy controls.Results Compared to healthy controls,the frequency of TNF-α-308 AA+AG genotype and

The immunophenotypic characteristics of 260 patients with CD5^+ B cell lymphoproliferative disorders

Objective To explore the immunophenotypic characteristics of CD5+B cell lymphoproliferative disorders(BLPD)of Chinese patients.Methods Immunophenotyping of bone marrow and(or)of peripheral blood was performed in patients with B-LPD by four color multiparameter flow cytometry analysis using a panel of monoclonal antibodes,and the patients clinical data were retrospectively analyzed.The difference in immunophenotypes

Clinical and biological characteristics of multiple myeloma with 1q21 amplification

Objective To study the clinical features of multiple myeloma(MM)patients with 1q21 amplification and the detection and biological characteristics of 1q21 copy number variation among different stages of plasma cell dyscrasias.Methods We analyzed the amplification