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Symmetry-breaking assembled porous calcite microspheres and their multiple dental applications 被引量:3
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作者 马明 颜燕宏 +5 位作者 漆超 祁胜财 陈世雄 尚光伟 汪饶饶 陈航榕 《Science China Materials》 SCIE EI CSCD 2017年第6期516-528,共13页
Biomedical applications of porous calcium car- bonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaki... Biomedical applications of porous calcium car- bonate (CaCO3) microspheres have been mainly restricted by their aqueous instability and low remineralization rate. To overcome these obstacles, a novel symmetry-breaking assembled porous calcite microsphere (PCMS) was con- structed in an ethanol/water mixed system using a two-step vapor-diffusion/aging crystallization strategy. In contrast to the conventional additive-induced crystallization method, the present strategy was performed under mild conditions and was free from any foreign additives, thus avoiding the potential contamination of the final product. Meanwhile, the prepared PCMSs were characterized by their highly uniform spherical morphology and large open pores, which are fa- vorable for large protein delivery. An antimicrobial study of immunoglobulin Y (IgY)-loaded PCMSs revealed excellent antimicrobial activity against Streptococcus mutans. More importantly, they showed surprisingly rapid transformation to bone minerals in physiological medium. Evaluation of the in vitro efficacy of PCMSs in dentinal tubule occlusion demonstrated their powerful potential to serve as a catalyst in the repair of dental hard tissue. Therefore, the developed PCMSs show great promise as multifunctional biomaterials for dental treatment applications. 展开更多
关键词 porous calcium carbonate REMINERALIZATION denti nal tubule occlusion antimicrobial protein delivery
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