Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the...Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.展开更多
Conductive hydrogels are good candidates for flexible wearable sensors, which have received considerable attention for use in human-machine interfaces, human motion/health monitoring, and soft robots. However, these h...Conductive hydrogels are good candidates for flexible wearable sensors, which have received considerable attention for use in human-machine interfaces, human motion/health monitoring, and soft robots. However, these hydrogels often freeze at low temperatures and thus, exhibit low transparency, weak mechanical strength and stretchability, as well as poor adhesion strength.In this paper, conductive organohydrogels were prepared by thermal polymerization of acrylamide and N-(3-aminopropyl)methacrylamide in a glycerol-water binary solvent using Na Cl as a conductive salt. Compared to other organohydrogels, our organohydrogels featured higher fracture stress(170 kPa) and greater stretchability(900%). The organohydrogels showed excellent antifreezing properties and high transparency(97%, at 400–800 nm wavelength) and presented outstanding adhesion strength to a variety of substrates. The conductive organohydrogels that were stored at -20℃ for 24 h could still respond to both strain and pressure, showing a high sensitivity(gauge factor=2.73 under 100% strain), fast response time(0.4 s), and signal repeatability during multiple force cycles(~100 cycles). Furthermore, the conductivity of cleaved antifreezing gels could be restored by contacting the broken surfaces together. Finally, we used our organohydrogels to monitor human tremors and bradykinesia in real-time within wired and wireless models, thus presenting a potential application for Parkinson’s disease diagnosis.展开更多
基金supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016)
文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.
基金supported by the National Natural Science Foundation of China(Grant Nos.51873137 and 61601317)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.20KJB510001)。
文摘Conductive hydrogels are good candidates for flexible wearable sensors, which have received considerable attention for use in human-machine interfaces, human motion/health monitoring, and soft robots. However, these hydrogels often freeze at low temperatures and thus, exhibit low transparency, weak mechanical strength and stretchability, as well as poor adhesion strength.In this paper, conductive organohydrogels were prepared by thermal polymerization of acrylamide and N-(3-aminopropyl)methacrylamide in a glycerol-water binary solvent using Na Cl as a conductive salt. Compared to other organohydrogels, our organohydrogels featured higher fracture stress(170 kPa) and greater stretchability(900%). The organohydrogels showed excellent antifreezing properties and high transparency(97%, at 400–800 nm wavelength) and presented outstanding adhesion strength to a variety of substrates. The conductive organohydrogels that were stored at -20℃ for 24 h could still respond to both strain and pressure, showing a high sensitivity(gauge factor=2.73 under 100% strain), fast response time(0.4 s), and signal repeatability during multiple force cycles(~100 cycles). Furthermore, the conductivity of cleaved antifreezing gels could be restored by contacting the broken surfaces together. Finally, we used our organohydrogels to monitor human tremors and bradykinesia in real-time within wired and wireless models, thus presenting a potential application for Parkinson’s disease diagnosis.
